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Traditional Chinese medicine for foot pain in a patient with complex regional pain syndrome: A case report

World Journal of Clinical Cases 2023年第30期11卷 7424-7431页

作者： Woo-Chul Shin Hyungsuk Kim Won-Seok Chung Clinical Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 02447South Korea Korean Medicine Kyung Hee UniversitySeoul 02447South Korea

BACKGROUND complex regional pain syndrome(CRPS)is characterized by pain as well as sensory,motor,and sudomotor ***,it is classified into two types CRPS-I and *** is no single diagnostic test or treatment approach for CRPS,and a multidisciplinary approach is gaining attention to improve patients’symptoms and their quality of *** SUMMARY A 35-year-old woman with an unremarkable medical history sought treatment for CRPS at a hospital of Korean *** her first visit,she was wheelchairbound due to severe pain in her left lower *** had edema and discoloration of the left *** was treated with a combination of traditional Chinese medicine(TCM)approaches,including acupuncture,moxibustion,pharmacopuncture,and herbal decoction,for approximately 20 *** foot and ankle outcome score(FAOS)and visual analog scale(VAS)score for pain were evaluated,along with general signs and *** symptoms,signs,FAOS,and VAS scores improved after treatment,with a significant 7-degree decrease in the VAS score and a 62-point increase in the FAOS ***,the foot swelling and discoloration gradually *** the phone follow-up,5 mo after the last visit,additional improvements in outcomes were *** Combined TCM treatment may be a reasonable and safe option for alleviating symptoms and improving function in patients with CRPS.

关键词： complex regional pain syndrome Traditional Chinese medicine Acupuncture Moxibustion Herbal medicine Case report

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High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic postischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord

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Neural Regeneration Research 2023年第11期18卷 2535-2544页

作者： Xin Jia Ziyang Li Xiafeng Shen Yu Zhang Li Zhang Ling Zhang Department of Neurology and Neurological Rehabilitation Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Department of Rehabilitation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghaiChina Key Laboratory of Cellular Physiology(Shanxi Medical University) Ministry of Educationand the Department of PhysiologyShanxi Medical UniversityTaiyuanShanxi ProvinceChina Key Laboratory of Central CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been *** studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous ***,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been *** the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different *** pain was reduced only in mice that engaged in high-intensity *** resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor ***,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal *** findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.

关键词： central sensitization chemerin receptor 23 chronic post-ischemia pain complex regional pain syndrome exercise-induced analgesia microglia neuroinflammation resolvin E1 spinal cord swimming

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pain management of hemiplegic shoulder pain post stroke in patients from Nanjing,China

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Neural Regeneration Research 2013年第25期8卷 2389-2398页

作者： Yi Zhu Bin Su Ning Li Hongzhu Jin Teaching and Research Department of Rehabilitation Treatment Second Clinical MedicineNanjing University of Traditional Chinese Medicine Wuxi Tongren International Rehabilitation Hospital Department of Rehabilitation Second Xiangya Hospital of Central South University Second Clinical Medicine Nanjing University of Traditional Chinese Medicine

We selected 106 hemiplegic patients with shoulder pain hospitalized after stroke from three hospi- tals in Nanjing, China between February 2007 and January 2012. All patients had complete clinical data sets and accounted for 45.5% of the inpatients because of stroke. Results showed that the number of patients with hemiplegic shoulder pain post stroke increased yearly, attacking mainly males 50-69 years of age. Of 106 patients, there were 60 cases （56.6%） of adhesive capsulitis, 19 （17.9%） of shoulder subluxation, 14 （13.2%） of complex regional pain syndrome, and 13 （12.6%） of central pain. The main symptoms were shoulder pain （100%）, limit of shoulder mobility （98.1%）, and adhesion of the scapula （56.6%）. MRI of the shoulder showed tendon and ligament lesions （57.1%） and rotator cuff tear （38.1%）. 53.8% of central pain was related to the thalamus, in addition to the basal ganglia, brain stem, and cerebellopontine angle. Shoulder pain, upper limb motor function, and function independence were significantly improved after comprehensive rehabilitation. In par- ticular, electroacupuncture based on basic physical therapy exhibited efficacy on shoulder subluxa- tion and complex regional pain syndrome. Multiple linear regression results showed a negative re- lationship of efficacy of pain management with the attack period of shoulder pain, involvement of the posterior limb of the internal capsule, and duration between onset and rehabilitation treatment, but a positive correlation with pain-related education, pain regression period, and pain diagnosis.

关键词： neural regeneration brain injury hemiplegia post stroke shoulder pain adhesive capsulitis shoulder subluxation complex regional pain syndrome grants-supported paper neuroregeneration

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Neuronal changes resulting in up-regulation of alpha-1 adrenoceptors after peripheral nerve injury

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Neural Regeneration Research 2014年第14期9卷 1337-1340页

作者： Peter D.Drummond Centre for Research on Chronic pain and Inflammatory Diseases Murdoch University Perth Western Australia Australia

Under normal conditions, the sympathetic neurotransmitter noradrenaline inhibits the production and release of pro-inflammatory cytokines. However, after peripheral nerve and tissue injury, pro-inflammatory cytokines appear to induce the expression of the alphalA-adreno- ceptor subtype on immune cells and perhaps also on other cells in the injured tissue. In turn, noradrenaline may act on up-regulated alphal-adrenoceptors to increase the production of the pro-inflammatory cytokine interleukin-6. In addition, the release of inflammatory mediators and nerve growth factor from keratinocytes and other cells may augment the expression of alphal-adrenoceptors on peripheral nerve fibers. Consequently, nociceptive afferents acquire an abnormal excitability to adrenergic agents, and inflammatory processes build. These mechanisms could contribute to the development of sympathetically maintained pain in conditions such as post-herpetic neuralgia, cutaneous neuromas, amputation stump pain and complex regional pain syndrome.

关键词： alphal-adrenoceptors up-regulation peripheral nerve injury nerve growth factor pro-inflammatory mediators complex regional pain syndrome

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