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Role of complements and Immunoglobulins in Duchenne Muscular Dystrophy

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Open Journal of Applied Sciences 2014年第6期4卷 323-346页

作者： Sanjeev Kumar Reena Mittal Sweety Depp Chand Jain Department of Mathematics Shri.K.K.JAIN. College Khatauli India Department of Neurology Safdarganj Hospital New Delhi India Department of Physics Central Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Muscular dystrophies are myopathies and tend to progressive, with ongoing degeneration and regeneration of muscle fibers. Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and polio myelitis are essentially diseases of the anterior horn cells of the spine. It has been reported in literature that humoral immunity is manifested by the antibodies production. These are special chemical substances that react against foreign body. Antibodies are serum proteins, which are immunoglobulins and possess antibody activity and are classified according to antigens and stimulate their production such as IgA, JgG, IgM, IgD and IgE. All the immunological parameters such as of C3, C4, IgG, IgM and IgA, which are measured in Duchenne muscular dystrophy go down in comparison to healthy subjects. Complement C3 and Complement C4 go down about 44.3% and 78.57% respectively from the normal values. The serum IgG, IgM and IgA levels were also go down about 65%, 84% and 99.56% respectively in comparison to healthy subjects. A trend between all the immunoglobulins has been set up and it is rAG.M > rMA.G. > rGM.A, while we have a trend in DMD cases is rMA.G. > rAG.M > rGM.A We are in a position to say that our data have a relevance of high authenticity and reliability to accept that there is a deficit in immunity in DMD cases. The deficit in immunity may be a cause to damage muscle for abnormal functioning.

关键词： complements Immunoglobulins Duchenne Muscular Dystrophy Regression Coefficients Multiple Correlation Coefficients

Role of complements and Immunoglobulins in Alzheimer’s Disease

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Open Journal of Applied Sciences 2014年第6期4卷 285-298页

作者： Sanjeev Kumar Reena Mittal Shweta Chaudhary Depp Chand Jain Department of Mathematics Shri.K.K.JAIN. College Muzaffarnagar India Department of Neurology Safdarganj Hospital New Delhi India Department of Physics Central Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Our findings show that the value of IgG in serum of Alzheimer’s Disease patients is (17.2059 ± 2.6317) g/l and in controls i.e. (17.6720 ± 3.1457) g/l. Values of IgM in AD patients go down up to 62.5% in comparison to healthy subjects. A sudden change was observed in the levels of IgA of AD patients. It has been put on the value 137.9% high in comparison to healthy subjects. The levels of complement C3 have also value of lower side and go down up to 52.66% in AD patients. The value of levels of complement C4 shows no deflection from the control values. On the basis of regression and multiple correlation analysis, we found that the partial correlation coefficients rGA.M, which has value 0.44815 in AD patients and 0.45555 in controls, do not show any resemblance. The multiple partial correlation rAM.G has value 0.3082 in AD patients and 0.3912 in controls slightly better correlated in comparison to healthy controls. Multiple *** has strongly correlation in comparison to controls. *** is also strongly correlated. Regression coefficients and regression equations are basic foundations of correlation measurements and show a specific character of variation. A relation between all the three multiple correlations has been established in the present work and it is given by the following relation *** > *** > ***.

关键词： complements Immunoglobulins Alzheimer’s Disease Regression Coefficients Multiple Correlation Coefficients

Cross-Cultural Analysis on complements

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海外英语 2014年第13期 182-183页

作者：刘恒北京农学院北京102206

Nativized varieties of English must reflect native pragmatic norms and cultural ***,as a polite social behavior,is analyzed from the perspective of Chinese English speaker and American English speaker to emphasize the... 详细信息

关键词： complements American English speaker Chinese Engli

The Case-agreement System in Subjunctive complements

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宏观语言学 2016年第1期4卷 52-79页

作者： Feras Saeed Qassim University Saudi Arabia

Unlike matrix verbs, the verb in subjunctive complements in Standard Arabic lacks tense; nonetheless, it inflects for agreement and mood. The subject of subjunctive verbs is Case-marked accusative if it surfaces in a preverbal position; and nominative if it appears in a postverbal position. In addition, the subjunctive verb shows agreement asymmetry with its subject, depending on the position of the subject. Subjunctive complements appear in tenseless contexts in this language, i.e. control structures, ECM-like structures, and obviative structures. In this paper, I provide a new analysis for subject-verb agreement asymmetry in these complements and account for the different Case markers that appear on their subject. In particular, I argue that feature-specification on the inflectional head T triggers the verbal agreement asymmetry in subjunctive complements. I also argue that formal features and nominative Case in these complements can be valued by a defective probe. Crucially, I argue that the defective probe can establish agreement and assign nominative Case in-situ, without resorting to A-movement, and the subsequent movement of the embedded subject to a preverbal position is triggered by the EPP feature on the O-complete T. The corollary of this investigation lends support to the assumption that the Case-agreement system in this language is not contingent on tense.

关键词： subjunctive complements defective probes agreement case Standard Arabic

Schur Complement of con-s-k-EP Matrices

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Advances in Linear Algebra & Matrix Theory 2012年第1期2卷 1-11页

作者： B. K. N. Muthugobal Ramanujan Research Centre Department of Mathematics Government Arts College (Autonomous) Kumbakonam India

Necessary and sufficient conditions for a schur complement of a con-s-k-EP matrix to be con-s-k-EP are determined. Further it is shown that in a con-s-k-EPr matrix, every secondary sub matrix of rank “r” is con-s-k-EPr. We have also discussed the way of expressing a matrix of rank r as a product of con-s-k-EPr matrices. Necessary and sufficient conditions for products of con-s-k-EPr partitioned matrices to be con-s-k-EPr are given.

关键词： con-s-k-EP Matrices Partitioned Matrices Schur complements

Immunological Variations in Epileptic Children

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Open Journal of Applied Sciences 2013年第1期3卷 71-91页

作者： Sanjeev Kumar Vinod Kumar D. C. Jain R. Mittal Department of Mathematics Shri. K.K. Jain College Khatauli India Department of Neurology Safdarganj Hospital New Delhi India Department of Physics Medical Physics Research Laboratory D.A.V. (P.G.) College Muzaffarnagar India

Epilepsy is one of the most frequent neurological problems. Despite of the advances and improvements in treatment of seizure disorders, immunological alterations such as immunoglobulins and complements have been measured. The levels of IgG in epileptic patients are found to be higher than controls. The levels of IgA, IgM, C3 and C4 were found to be lower in all the controls. Student’s t-test were also applied. Multiple and regression analysis, have been also carried out. A trend has also set up in the present study. An alteration in the immune mechanism of epileptic patients is required. Ketogenic diet may be given and the balance of trace elements like Na, K, Zn, Fe, Ca, Mg and Cu may be maintained to alter the immune mechanism of the epileptic patients. Green leafy vegetables may be given to the patients to control the seizure. Immunity is related with the food we eat. By adjusting the immunity with proper diet the severity of epileptic attack or any disease may be reduced.

关键词： Epilepsy Immunoglobulins Central Nervous System complements

Semelfactivity in Igbo

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宏观语言学 2020年第2期8卷 56-63页

作者： Sopuruchi Christian Aboh Amarachi Jennifer Onuorah University of Nigeria Nigeria

This paper examines semelfactivity in the Igbo language. It seeks to highlight semelfactive verbs and other semelfactive sentential elements. The data for the study were obtained through introspection which were confirmed by two native speakers of Igbo and were analysed descriptively. From the study, it was discovered that the semelfactive verbs in Igbo that co-occur with bound verb complements for emphasis are takwu ‘whisper’, lo‘swallow’, nwụ ‘die’ and hụpe ‘glimpse’ whereas kọ ‘scratch’, tabi ‘blink’, ze ‘sneeze’, kụ‘knock’, ti ‘shout’, wuli ‘jump’ (wu ‘jump’. -li ‘upward’ as opposed to wuda ‘jump downwards)’, gba ‘kick’, nyụ ‘fart’ and kwa ‘cough’ that take inherent complement *** research also revealed that na mberede ‘suddenly’ and na ntabi anya ‘in a twinkle of an eye’ are semelfactive adverbials in the Igbo language. Based on the findings, the paper concludes that in Igbo, semelfactivity entails a one-time action and a spontaneous or instantaneous action.

关键词： semelfactivity semelfactive verbs adverbials Igbo complements