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combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis——combined biomarkers in NASH non-invasive diagnosis

Combined serum biomarkers in non-invasive diagnosis of non-a...

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第十四届中国体视学与图像分析学术会议

作者： Yang Mei Xu Dongping Liu Yuan Guo Xiaodong Li Wenshu Guo Chaonan Zhang Hongping Gao Yinjie Mao Yuanli Zhao Jingmin Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital

Background Non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis even hepatocellular carcinoma(HCC).However,non-invasive biomarkers for NASH diagnosis remain poorly applied in clinical *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1 Ra),pigment epithelium-derived factor(PEDF)and osteoprotegerin(OPG)in diagnosing NAFLD and *** 179 patients with biopsy-proven NAFLD were enrolled as training group,91 ageand gender-matched healthy subjects were recruited at the same time as controls.63 otherNAFLD patients were separately collected as validation group.45 alcoholic fatty liver disease(AFLD)patients,50hepatitis B virus(HBV)patients,52 hepatitis C virus(HCV)patients were also *** biomarker levels were measured by enzyme-linked immunosorbent *** serum levels of CK-18-M30,FGF-21,IL-1Ra and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(Pbiomarker,stepwise combination of CK-18-M30,FGF-21,IL-1 Ra,PEDF and OPG can further improve the accuracy in diagnosing NASH.

关键词： Non-alcoholic steatohepatitis Non-invasive diagnosis combined serum biomarker Accuracy

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combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis

Combined serum biomarkers in non-invasive diagnosis of non-a...

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第九届全国生物医学体视学学术会议、第十二届全军军事病理学学术会议、第八届全军定量病理学学术会议

作者： Mei Yang DongPing Xu Yuan Liu Xiaodong Guo Wenshu Li Chaonan Guo Hongping Zhang Yinjie Gao Yuanli Mao Jingmin Zhao Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital 中国人民解放军第三O二医院病现研究与诊断中心

Backgroud&Aims:Non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis and even hepatocellular carcinoma(HCC).Seeking non-invasive biomarkers in diagnosing NASH is a worldwide heated *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1Ra),pigment epithelium-derived factor(PEDF) and osteoprotegerin(OPG) in diagnosing NAFLD and ***:A large-cohort prospective study was conducted on 242 patients with biopsy-proven NAFLD,randomly divided into NAFLD training group(n=179) and validation group(n=63),and 91 ageand gender-matched healthy subjects as *** biomarker levels were measured by enzyme-linked immunosorbent ***:serum levels of CK-18-M30,FGF-21,IL-IRa and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P respectively in validation ***:Stepwise combination of CK-18-M30,FGF-21,IL-IRa,PEDF and OPG can greatly improve the accuracy in diagnosing NASH compared to single biomarker,which is worth clinical application.

关键词： Non-alcoholic Steatohepatitis Non-invasive diagnosis combined serum biomarker Accuracy

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