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Influence of traditional chinese medicines on the in vivo metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis

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Journal of Pharmaceutical Analysis 2022年第2期12卷 270-277页

作者： Linlin Li Xinxiang Yu Dongmin Xie Ningning Peng Weilin Wang Decai Wang Binglong Li Department of Clinical Pharmacy School of PharmacyShandong First Medical University&Shandong Academy of Medical SciencesTai'anShandong271016China

A fast,reliable,and cost-effective liquid chromatography-tandem mass spectrometry method was established to determine the effects of the traditional chinese medicine employed to treat coronavirus disease 2019,namely,Lianhua Qingwen granules,Huoxiang Zhengqi capsules,Jinhua Qinggan granules,Shufeng Jiedu capsules,and Angong Niuhuang pills,on the pharmacokinetics of lopinavir/ritonavir in *** samples were prepared using the protein precipitation method and atazanavir was selected as the internal standard(IS).Separation was performed on an Agilent ZORBAX eclipse plus C18(2.1 mm×50 mm,1.8 μm)column using acetonitrile and water containing 0.1%formic acid as the mobile phase for gradient *** flow rate was 0.4 mL/min and the injection volume was 2 μ*** Jet Stream electrospray ionization was used for mass spectrometry detection under positive ion multiple reaction monitoring mode at a transition of m/z 629.3→447.3 for lopinavir,m/z 721.3→296.1 for ritonavir,and m/z 705.4→168.1 for the *** method showed good linearity in the concentration range of 25→2500 ng/mL(r=0.9981)for lopinavir and 5e500 ng/mL(r=0.9984)for *** intra-day and inter-day precision and accuracy were both within±15%.Items,such as dilution reliability and residual effect,were also within the acceptable *** method was used to determine the effects of five types of traditional chinese medicines on the pharmacokinetics of lopinavir/ritonavir in *** pharmacokinetic results showed that the half-life of ritonavir in the groups administered Lianhua Qingwen granules and Huoxiang Zhengqi capsules combined with lopinavir/ritonavir was prolonged by approximately 1.5-to 2-fold relative to that in the control ***,the pharmacokinetic parameters of lopinavir were ***,the results of this study offer important theoretical parameters for the effective clinical use of five types of traditional chinese medicines combined with lopinavir/ritonavir to reduce the

关键词： Lopinavir/ritonavir combination of chinese and western medicine Drug-drug interaction Ultra high-performance liquid chromatography-tandem mass spectrometry Pharmacokinetics COVID-19

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Meta-analysis of clinical efficacy of combined traditional chinese and western medicine in the treatment of granulomatous mastitis

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Journal of Hainan Medical University 2020年第10期26卷 51-55页

作者： Chao-Qun Bi Han-Han Chen Miao-Miao Liu Jing-Wei Li College of Traditional chinese Medicine Shandong University of Traditional Chinese MedicineJinanShandong Province250014 Department of Mammary Gland Thyroid Surgery First Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinanShandong Province250014 First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong Province250014

Objective:To systematically evaluate the clinical effect (including effective rate and recurrence rate) of the combination of traditional chinese and western medicine in the treatment of granulomatous mastitis (GM).Methods: Computer searches CNKI, Wanfang database, VIP, PubMed, web of science and EMBASE, chinese biomedical database, and selects randomized controlled trial (RCT) of treating granulomatous mastitis with the combination of traditional chinese and western medicine. The retrieval time is from July 2019 to July 2019. Then, we used Revman 5.3 software to meta analyze the ***: Nine RCTs were included, six of which were effective observation, two of which were recurrence rate observation, one of which was effective observation and reexamination rate observation. A total of 664 patients were included, including 456 in the experimental group and 208 in the control group. After analysis, it was found that the effective rate of GM in the experimental group was 92.3%, which was significantly higher than that in the control group (western medicine alone) by 75.5% (or = 4.09, 95% CI (2.28, 7.36), P chinese and western Medicine) was 21.6%, which was significantly lower than that in the control group (treated with western medicine alone) by 55.7% (or = 0.19, 95% CI (0.10, 0.37), P combination of traditional chinese and western medicine in the treatment of granulomatous mastitis can not only improve the effective rate of clinical treatment, but also reduce the recurrence rate of granulomatous mastitis.

关键词： combination of chinese and western Medicine Granulomatous mastitis Meta analysis Effective rate Recurrence rate

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