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Oral health in China: from vision to action

International Journal of Oral Science 2018年第1期10卷 1-6页

作者： Xuedong Zhou Xin Xu Jiyao Li Deyu Hu Tao Hu Wei Yin Yujiang Fan Xingdong Zhang State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan University State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Preventive Dentistry West China Hospital of StomatologySichuan University National Engineering Research Center for Biomaterials Sichuan University

Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people’s all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China. We also described and analyzed the recently released health policies of the Chinese government, which aim to guide midterm and long-term oral health promotion in China. More importantly, we called for specific actions to fulfill the larger goal of oral health for the nation. The implementation of primordial prevention efforts against oral diseases, the integration of oral health into the promotion of overall health, and the management of oral diseases in conjunction with other chronic non-communicable diseases with shared risk factors were highly recommended. In addition, we suggested the reform of standard clinical residency training, the development of domestic manufacturing of dental equipment and materials, the revitalization traditional Chinese medicine for the prevention and treatment of oral diseases, and integration of oral health promotion into the Belt and Road Initiative. We look forward to seeing a joint effort from all aspects of the society to fulfill the goal of Healthy China 2030 and ensure the oral health of the nation.

关键词： GALLA-CHINENSIS EXTRACT NIDUS-VESPAE EXTRACT CHEMICAL-FRACTIONS GLOBAL BURDEN RISK-FACTOR PERIODONTAL-DISEASE ALZHEIMERS-DISEASE colorectal-cancer DEMINERALIZATION REMINERALIZATION

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COMPARISON OF SHAMS' TEST FOR RECTAL MUCUS TO AN IMMUNOLOGICAL TEST FOR FECAL OCCULT BLOOD IN LARGE INTESTINAL CARCINOMA SCREENING ANALYSIS OF A CHECK-UP OF 6480 ASYMPTOMATIC SUBJECTS

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中华医学杂志(英文版) 1993年第10期106卷 739-742页

作者：周殿元冯福才张亚历赖卓胜张万岱李立波许国良万田漠潘德寿周丹张月彩李树彬 Department of Digestion Nanfang HospitalThe First Military Medical University

The sugar moiety detected from rectal mucus by the Galactose oxidase-schiff (Shams’ test) is considered a substitutive test for immunological fecal occult blood test (FOBT) in screening colorectal carcinoma. Two strategies of screening were applied in 6480 subjects over 40 years of age, and 130 cm flexible colonoscope used for sigmoidoscopy or pancolonoscopy. Of them, 3820 were taken for immune FOBT (SPA test) and Shams’ test. Only those who showed positive tests were chosen for 60 cm flexible sigmoidoscopy, while another 2660 subjects for both sigmoidoscopy and tests at the same time. Additionally, 130 cm flexible pancolonoscopy was carried out in 103 individuals with positive Shams’ test for evaluating the false positive rate. Shams’ test showed a sensitivity of 85.7% for colorectal cancer, 47.1% for adenomas in preselected patients, while the positive rate of SPA test were 90.5% and 41.2% respectively. In 3820 asymptomatic subjects undergoing sequential screening (aged 45 years and higher), Shams’ test showed 9.1% positive, SPA showed 11.2% and 620(16.2%) subjects were selected for sigmoidoscopy based on their positive galactose oxidase result or positive FOBT result. Two early stage carcinomas and 33 adenomas (0.32% and 4.2% respectively in sigmoidoscopy) were found. Another 2 660 subjects were taken for sigmoidoscopy screening. Four carcinomas and 78 adenomas were found. Of them, only two carcinoma (50%) and 17(21.8%) or 22(28.2%) adenomas were positive in Shams’ or SPA test. But both tests combined in screening showed a rate of 61.3% in adenomas and 75.0% in cancers. 103 subjects with positive Shams’ test were taken for pancolonoscopy. 82.5% showed no lesions. On these, we conclude that simple Shams’ test can be regarded as a complementary test for immunological FOBT in screening colorectal carcinomas.

关键词： colorectal-cancer

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Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines:Role of cytokines

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World Journal of Gastroenterology 2014年第11期20卷 2979-2994页

作者： Sajjad Khan Silke Cameron Martina Blaschke Federico Moriconi Naila Naz Ahmad Amanzada Giuliano Ramadori Ihtzaz Ahmed Malik Clinic of Gastroenterology and Endocrinology University Medical CenterRobert-Koch-Str. 4037075 GoettingenGermany

AIM:To study KRAS/BRAF mutations in colorectalcancer(CRC)that influences the efficacy of *** develop strategies for overcoming combination of ***:Five colonic cell-lines were investigated:DLD-1 with KRAS(G13D)mutation,HT 29 and Colo205 with BRAF(V600E)mutation as well as the wild type(Wt)cell-lines Caco2 and ***-1(KRAS),HT-29(BRAF)and Caco2(Wt)cell lines were treated with cytokines(TNFα50 ng,IL-1β1 ng and IFNγ50ng)and harvested at different time points(1-24 h).KRAS inhibition was performed by the *** colorectal cancer cells DLD-1 and Caco2 were used for KRAS *** 70%confluency were confirmed before transfection with small interferring RNA(siRNA)*** the synthetic siRNA sequences were designed in our *** RNA and protein was isolated from the cells for RT-PCR and Western *** of the Western blotting was analyzed with the Image J software(NIH).Results are shown as mean±***:RT-PCR analysis in non-stimulated cells showed a low basal expression of TNFαand IL-1βin the DLD-1 KRAS-mutated cell-line,compared to Caco2wild *** detection was found for IL-6 and IFNγin any of the studied cell *** contrast,pro-angiogenic chemokines(CXCL1,CXCL8)showed a high constitutive expression in the mutated cell-lines DLD-1(KRAS),HT-29 and Colo205(BRAF),compared to wild type(Caco2).The anti-angiogenic chemokine(CXCL10)showed a high basal expression in wild-type,compared to mutated *** down-regulation by siRNA showed a significant decrease in CXCL1 and CXCL10gene expression in the DLD-1(KRAS)cell-line in comparison to wild type(Caco2)at 72 h after KRAS *** contrast,the specific KRAS inhibition resulted in an up-regulation of CXCL1 and *** results of our study show a higher expression of pro-angiogenic chemokines at basal level in mutated cell-lines,which was further increased by cytokine ***:To summarize,basal chemokine gene expres

关键词： colorectal-cancer KRAS BRAF CXCL1(GROα) CXCL10(IP-

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