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The influence of the gut microbiota on the bioavailability of oral drugs

Acta Pharmaceutica Sinica B 2021年第7期11卷 1789-1812页

作者： Xintong Zhang Ying Han Wei Huang Mingji Jin Zhonggao Gao State Key Laboratory of Bioactive Substance and Function of Natural Medicines Department of PharmaceuticsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Due to its safety,convenience,low cost and good compliance,oral administration attracts lots of attention.However,the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract.One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs,influencing the drug transport process and altering some gastrointestinal properties.In this review,we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs,which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.

关键词： Gut microbiota Oral drugs Bioavailability Probiotics colon-specific drug delivery system

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Pectin-chitosan complex: Preparation and application in colon-specific capsule

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International Journal of Agricultural and Biological Engineering 2015年第4期8卷 151-160页

作者： Wu Li Wang Hao Zhu Xiaohua Hou Yinchen Liu Wangwang Yang Gongming Jiang Aimin College of Food Engineering Henan University of Animal Husbandry and EconomyZhengzhou 450011China College of Food Science South China Agricultural UniversityGuangzhou 510642China

Pectin-chitosan complex was prepared as a candidate material for colon-specific capsule.First,the effects of beating on the properties of complex films were explored.Fourier transform infrared(FT-IR)spectroscopy was used to analyze the reaction mechanics,and an in vitro simulation experiment was performed to determine the degradation performance.Second,the capsule was prepared using pectin-chitosan complex as the main raw material;its targeting effect was evaluated and analyzed.Results indicated that the film became smooth and compact by beating.FT-IR data indicated that cross-linking occurred between the hydroxyl group of pectin and the amino group of chitosan to form a network structure.In vitro experiment showed that the pectin-chitosan complex film could not be degraded in the simulated gastric and intestinal fluids.However,pectin-chitosan complex could be degraded in the simulated colonic fluid,so it could be a potential candidate for colon-specific capsule.Because the complex has no ability for forming hard capsule,the carrageenan and starch were added to increase the flexibility,gelation,transparency and mechanical properties of the film.The preferred composition suitable for preparing the capsule was a mass ratio(2:1:1)of pectin-chitosan/carrageenan/starch mixture.The capsule showed excellent features in terms of shape,water content,and brittleness.The drug release rate reached 93.33%in colonic fluid for 1 h when bovine serum albumin was the model drug.Therefore,pectin-chitosan may be considered as a new material for colon-targeted capsule.

关键词： pectin-chitosan complex polyelectrolyte carrageenan starch capsule colon-specific drug delivery system

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