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Pleural effusion,ascites,colon ulcers and hematochezia:What we can learn from the diagnostic process of a patient with plasma cell myeloma:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5196-5207页

作者： Ming-Xian Yan Department of Gastroenterology The First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Plasma cell myeloma(PCM)is characterized by hypercalcemia,renal impairment,anemia,and bone *** pleural effusion,ascites,abdominal pain,and bloody stool are common manifestations of lung disease or gastrointestinal disorders,they are rarely observed in patients with *** SUMMARY A 66-year-old woman presented with complaints of recurrent chest tightness,wheezing,and abdominal bloating accompanied by bloody *** tomography revealed pleural effusion and *** effusion tests showed inflammation,but the T-cell spot test and carcinoembryonic antigen were *** showed colonic mucosal edema with ulcer formation and local intestinal lumen *** revealed enlarged atria and reduced left ventricular systolic *** diagnosis remained *** testing revealed elevated blood light chain lambda and urine immunoglobulin *** immunofixation electrophoresis was positive for immunoglobulin G lambda *** cytology of the bone marrow showed a high proportion of plasma cells,accounting for about 4.5%.Histopathological examination of the bone marrow suggested *** cytometry showed abnormal plasma cells with strong expression of CD38,CD138,cLambda,CD28,CD200,and *** in situ hybridization gene testing of the bone marrow suggested 1q21 gene amplification,but cytogenetic testing showed no clonal *** mucosa and bone marrow biopsy tissues were negative for Highman Congo red *** patient was finally diagnosed with *** A diagnosis of PCM should be considered in older patients with pleural effusion,ascites,and multi-organ injury.

关键词： Plasma cell myeloma Pleural effusion Ascites Hematochezia colon ulcers Bone marrow aspirate Case report

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