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Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-Ying Zeng Zhi-Hong Yu Peng Shen Zheng-Quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same individual.Synchronous MPCs are rarer than solitary cancers or metachronous MPCs.Accurate diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these cases.CASE SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory results.After multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were initiated.Based on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 cycles.Subsequently,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained stable.CONCLUSION Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma colon adenocarcinoma Cetuximab Chemotherapy Case report

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colon adenocarcinoma in a Retrograde Intussusception: A Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 153-160页

作者： Carlos Hernández Brito Pedro Arredondo Ruiz Brenda Paola Sáenz Dávila Arsenio Torres Delgado Luis Eduardo Méndez Turrubiates Luis Ángel Amezcua Toledo Omar Josué Herrera López Surgical Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Clinical Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico General and Laparoscopic Surgery Corporativo M&#233dico-Quir&#250rgico Torres Veracruz Mexico Radiation Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Radiology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Anatomical Pathology Department Centro Oncol&#243gico Onkolid Veracruz Mexico

Background: Intussusception is defined as a telescoping of a proximal gastrointestinal segment with its mesentery to a distal one, only 5% occur in adults and in colon the probability that it is caused by a malignant disease is up to 65%. Only 1% occurs in a retrograde manner, the rest occur in an anterograde manner. Aim: Describe the clinical presentation of an intussusception in the adult patient as well as its most frequent causes and possible complications that influence decision making for a definitive treatment. Case Presentation: A 66-year-old woman diagnosed with colon adenocarcinoma who underwent elective transverse colectomy and colonic anastomosis with an incidental finding of a transverse colon tumor in a retrograde intussusception was studied. Conclusion: In any adult patient with an intussusception especially in colon a neoplasia should be suspected and the affected segment should be resected without being reduced due to the risk of perforation and tumor dissemination.

关键词： colon Cancer colon adenocarcinoma colonic Intussusception Intussusception

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GINS1 as a Novel Biomarker of Survival in colon adenocarcinoma Patients-A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 60-67页

作者： Muhammad Umair Abid Yasir Hameed Department of Plant Breeding and Genetics University of Agriculture FaisalabadFaisalabadPakistan Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study focused on elaborating the role of GINS1 expression and its regulatory mechanisms in colon adenocarcinoma (COAD). Using the UALCAN informational index, GINS1 expression assessment unveiled a critical up- regulation in malignant cells that stood out from normal controls, suggesting its contribution to COAD expansion. Further dismantling GINS1 expression across various boundaries revealed unsurprising up-regulation in different malignant development stages, racial groups, genders, and age classes in COAD patients, characteristics for its imperative role in cancer progression. Moreover, this study investigated the promoter methylation status of GINS1, uncovering a critical uniqueness between COAD samples and normal controls. Analyzing promoter methylation across various clinical boundaries uncovered powerful variations, with particular methylation patterns seen across cancer stages, race groups, genders, and age groups. Survival analysis using the Kaplan-Meier (KM) plotter tool showed a colossal connection between GINS1 expression levels and overall survival (OS) in COAD patients, with low GINS1 expression interfacing with higher OS. Additionally, mutational examination using the cBioPortal stage revealed that no critical change was found in COAD. Overall, these findings revealed the complex contribution of GINS1 in COAD pathogenesis, underlining its actual limit as a prognostic biomarker and supportive therapeutic agent in COAD management.

关键词： colon adenocarcinoma Diagnosis Treatment

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Metachronous isolated penile metastasis from sigmoid colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第31期10卷 11658-11664页

作者： Guo-Lin Yin Jiang-Bo Zhu Cheng-Lin Fu Ru-Liang Ding Jun-Miao Zhang Qian Lin Department of Urology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Pathology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Anorectology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina

BACKGROUND Sigmoid colon adenocarcinoma has a high incidence among gastrointestinal tumors,and it very rarely metastasizes to the penis.The literature reports that the prognosis after penile metastasis is generally poor,with a median survival of about 9 mo.Metachronous isolated metastasis to the penis originating from sigmoid colon adenocarcinoma has not been reported so far.Here,we report a case of sigmoid colon adenocarcinoma with isolated penile metastasis occurring 2 years after surgery.The mass was pathologically confirmed as metastatic adenocarcinoma,and oral chemotherapy with capecitabine was given after surgery.The tumor did not recur during the 2-year follow-up period.CASE SUMMARY A 79-year-old man presented to the urology department with"a mass located at the root of the penis since 1 mo".Enhanced computed tomography(CT)examination suggested a 12 mm×10 mm×9 mm nodule at the root of the right penile corpus cavernosum.Cranial,pulmonary,and abdominal CT;and bone scan did not show any tumorigenic lesions.The carcinoembryonic antigen(CEA)level was slightly elevated(6.01 ng/mL,reference value 0-5 ng/mL).The patient had undergone laparoscopic radical sigmoidectomy for sigmoid colon cancer 2 years ago.The postoperative pathology showed moderately differentiated adenocarcinoma of the sigmoid colon,and the stage was PT2N0M0.The penile mass was removed under general anesthesia.The postoperative pathology showed adenocarcinoma,and immunohistochemistry showed CDX2(+),CK20(+),and Villin(+).Based on the medical history,he was diagnosed with penile metastasis from sigmoid colon adenocarcinoma.The CEA level returned to normal(3.34 ng/mL)4 d after surgery.Oral chemotherapy with capecitabine was given subsequently,and tumor recurrence was not found during the 2-year follow-up period.CONCLUSION To our knowledge,this is a rare case of metachronous isolated penile metastasis from sigmoid colon adenocarcinoma.The penis is a potential site of metastasis of colon adenocarcinoma,and the possibility of metastasis should be consid

关键词： colon adenocarcinoma Penis Metastases Metachronous adenocarcinoma Case report

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Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma

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World Journal of Clinical Cases 2021年第29期9卷 8671-8693页

作者： Yan-Dong Miao Zhi-Yong Kou Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND colon adenocarcinoma(COAD)is one of the most common and fatal malignant tumors,which increases the difficulty of prognostic predictions.Thus,new biomarkers for the diagnosis and prognosis of COAD should be explored.Ferroptosis is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide accumulation.However,the predictive value of ferroptosis-related genes(FRGs)for COAD still needs to be further clarified.AIM To identify some critical FRGs and construct a COAD patient prognostic signature for clinical utilization.METHODS The Cancer Genome Atlas database(TCGA)and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical information.Differentially expressed FRGs were recognized using R and Perl software.We constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression analysis.COAD patients from the Gene Expression Omnibus cohort were utilized for verification.RESULTS Our research showed that most of the FRGs(85%)were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD cohort.Seven FRGs were related to overall survival(OS)in the univariate Cox analysis(all P1,P<0.01).The predictive capacity of the model was verified by a receiver operating characteristic curve analysis.In addition,a nomogram based on the expression of five hub FRGs and risk score can precisely predict the OS of individual COAD cancer patients.Immune correlation analysis and function

关键词： colon adenocarcinoma Ferroptosis Immune status Prognosis Overall survival

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CHANGES OF NUCLEAR MATRIX PROTEIN AND ITS RELATIONSHIP WITH c-erbB-2 IN HUMAN colon adenocarcinoma

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Chinese Journal of Cancer Research 2005年第4期17卷 255-259页

作者：王娅兰高静李圆圆 Department of Pathology Chongqing University of Medical Sciences Department of Pathology Second Affiliated Hospital Chongqing University of Medical Sciences

Objective： Nuclear matrix protein is tissue, cell-type specific, and tumor-relative. It plays an important role in the regulation of intranuclear processes. Some researches also showed that a c-erbB-2 promoter-specific DNA-binding nuclear matrix protein is present only in malignant human breast tissues and induces mitogenesis and cell surface expression of the c-erbB-2 protein in resting NIH/3T3 cells. But it is not clear that how it in colon adenocarcinomas. Methods： Two-dimensional gel electrophoretic method was used for NMP identification and immunohistochemistry was used for c-erbB-2 detection in 12 cases of colon adenocarcinomas and matched adjacent normal colon tissues. Results： 5 different nuclear matrix proteins （named C1-C5） were identified in 12 colon adenocarcinoma specimens, but not in the matched adjacent normal colon tissues; 3 nuclear matrix proteins （named N1-N3） were identified in all 12 matched adjacent normal colon tissues, but not in colon adenocarcinoma specimens. A nuclear matrix protein （named N4） was detected in all of 9 moderated-well differentiated adenocarcinomas and all 12 matched adjacent normal colon tissues, but not in 3 poor-differentiated adenocarcinomas. All of the 10 colon adenocarcinomas which had the nuclear matrix protein C4 were c-erbB-2 expression positive. Conclusion： The data suggest that there are specific nuclear matrix proteins in colon adenocarcinomas and its subtypes, which maybe valuable to serve as markers of colon adenocarcinomas in future. Nuclear matrix protein C4 probably is a c-erbB-2 promotor-specific nuclear matrix protein in colon adenocarcinomas, and may induce the expression of c-erbB-2.

关键词： colon adenocarcinoma Nuclear matrix protein c-erbB-2 Two-dimensional gel electrophoresis

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Unusual Spreading of colon adenocarcinoma into the Right Hip Area: A Case Report

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Journal of Cancer Therapy 2012年第6期3卷 985-988页

作者： Renata Dobrila Dintinjana Duska Petranovic Gorazd Pilcic Vjekoslav Ilijic Davor Petranovic Marijan Dintinjana Department of Oncology University Hospital Center RijekaRijekaCroatia Department of Internal Medicine University Hospital Center RijekaRijekaCroatia Department of Internal Medicine Salem HospitalBernSwitzerland Department of Radiology Medico PolyclinicRijekaCroatia Private Clinic of Dr.Dintinjana RijekaCroatia.

adenocarcinoma is the most common colon cancer type. This form of colonic neoplasms usually metastasizes initially to regional lymphatic system and through the blood circulation to the lungs and liver, while other forms of expansion and involvement of other organ systems are less common. Extraluminal carcinoma is very rare. Only a few authors describe the direct spread of cancer to adjacent structures and organs. In this paper we present a case of a 76-year old patient with tumor mass extending from the colon to the right hip area “per continuitatem”. The patient had no symptoms and signs that would indicate the presence of neoplastic process in the colon. Only a discomfort in right leg was present and finally tumor mass was visualized. Biopsy and patohistology findings confirmed final diagnosis and type of tumor in the right hip region. Pathohistologicaly tumor was adenocarcinoma.

关键词： colon adenocarcinoma Local Spreading Right Hip

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RNA demethylase ALKBH5 prevents colon adenocarcinoma progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

RNA demethylase ALKBH5 prevents colon adenocarcinoma progres...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Mengyue Tian Xinghui Zhuang Zhiwen Zhao Chunyan Dai Fujian Medical University 福建医科大学附属协和医院

Background: N6-methyladenosine(m6 A) is the most abundant reversible methylation modification of eukaryotic mR NA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6 A demethylase ALKBH5 in colon adenocarcinoma(COAD).Methods: The expression of ALKBH5 and its clinicopathological impact were evaluated in COAD cohorts.The effects of ALKBH5 on the biological characteristics of COAD cells were investigated on the basis of gain-of-function and loss-of-function analyses. Subcutaneous and orthotopic models further uncovered the role of ALKBH5 in tumour growth. mR NA and m6 A sequencing and assays of m6 A methylated RNA immunoprecipitation-qPCR(MeRIP-qPCR) were performed to identify the targeted effect of ALKBH5 on PER1. P53-binding sites in the ALKBH5 promoter were investigated by ChIP and luciferase assays to reveal the interplay between ALKBH5 and PER1-activated ATM-CHK2-P53/CDC25 C signalling.Results: ALKBH5 loss characterized the occurrence and poor clinicopathological manifestations in patients with COAD. Overexpression of ALKBH5 reduced tumoural proliferative, migrative, invasive activities in vitro and ameliorated tumour growth in vivo, whereas ALKBH5 knockdown facilitated COAD progression. Mechanistically, ALKBH5 posttranscriptionally activated PER1 by m6 A demethylation in an m6 A-YTHDF2-dependent manner. PER1 upregulation led to the reactivation of ATM-CHK2-P53/CDC25 C signaling, which inhibited cell growth. P53-induced activation of ALKBH5 transcription acted as a feedback loop regulating the m6 A modifications in COAD.Conclusion: ALKBH5 serves as a COAD suppressor by regulating the posttranscriptional activation of PER1 through m6 A abolishment, which may highlight a demethylation-based approach for COAD diagnosis and therapy.

关键词： colon adenocarcinoma m6A ALKBH5 PER1

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IN VIVO NEAR-INFRAREDFLUORESCENCEIMAGING OF HUMANcolonadenocarcinomaBY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEDMUCIN

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 407-422页

作者： RALPH S.DACOSTA YING TANG TUULA KALLIOMAKI RAYMOND M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARCON BRIAN C.WILSON Division of Biophysics and Bioimaging Ontario Cancer Institute 610 University of TorontoTorontoOntarioM5G 2M9Canada Department of Medical Biophysics University of Toronto Princess Margaret Hospital/Ontario Cancer Institute University Health NetworkTorontoOntarioCanada NIH/NCI Radiation Oncology Branch BethesdaMDUSA Division of Clinical Investigation and Human Physiology Toronto General Hospital Research Institute and University of Toronto Leslie Dan Faculty of Pharmacy TorontoOntarioCanada Laboratory for Applied Biophotonics University Health Network TorontoOntarioCanada Campbell Family Institute for Breast Cancer Research University Health Network/Ontario Cancer Institute Department of Medical Biophysics and Immunology Toronto OntarioCanada St.Michael’s Hospital Center for Therapeutic Endoscopy and Endoscopic Oncology Toronto OntarioCanada

Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy.

关键词： Autofluorescence imaging endoscopy colon adenocarcinoma TAG72 CC49 mucin monoclonal antibody conjugate confocal fluorescence microscopy.

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colon carcinoma treated with oxaliplatin and capecitabine in a 12-year-old child

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World Journal of Pediatrics 2014年第1期10卷 86-88页

作者： Dong-Lai Hu Xiao-Dong Guo Zhi-Nan Sun Yan-Min Zhao Department of Pediatric Surgery Jinhua Hospital of Zhejiang UniversityJinhua Municipal Central HospitalJinhua 321000China

Background:XELOX(oxaliplatin 130mg/m^(2)iv,capecitabine 1000mg/m^(2)bid oral d1–14,q3w)chemotherapy has never been used in children.In this report,we present a case of a 12-year-old girl with colon adenocarcinoma,treated with surgery and XELOX chemotherapy.Methods:On admission,the girl complained of abdominal pain and intestinal obstruction.Physical examination revealed a distended abdomen with tenderness on the left upper quadrant.Barium enema revealed a stenotic lesion at the distal end of the transverse colon,and abdominal computed tomography showed acute obstruction and a colonic mass.Laparotomy was performed after the failure of conservative treatment.Results:The mass was originated from the transverse colon.Frozen sections of the specimens revealed an adenocarcinoma.Transverse colectomy was performed and regional lymph nodes were removed.Pathological examination confirmed that the mass was a poorly differentiated adenocarcinoma,and XELOX chemotherapy was used.No evidence of recurrent or metastatic tumor was found after 18 months.Conclusion:Although complete resection is the most effective treatment,XELOX chemotherapy is beneficial to the improvement of clinical outcome of patients with colon adenocarcinoma.

关键词： chemotherapy colon adenocarcinoma XELOX regimen

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