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Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma

World Journal of Clinical Cases 2021年第29期9卷 8671-8693页

作者： Yan-Dong Miao Zhi-Yong Kou Jiang-Tao Wang Deng-Hai Mi The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Dean’s Office Gansu Academy of Traditional Chinese MedicineLanzhou 730000Gansu ProvinceChina

BACKGROUND colon adenocarcinoma(COAD)is one of the most common and fatal malignant tumors,which increases the difficulty of prognostic ***,new biomarkers for the diagnosis and prognosis of COAD should be *** is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide ***,the predictive value of ferroptosis-related genes(FRGs)for COAD still needs to be further *** To identify some critical FRGs and construct a COAD patient prognostic signature for clinical *** The Cancer Genome Atlas database(TCGA)and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical *** expressed FRGs were recognized using R and Perl *** constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression *** patients from the Gene Expression Omnibus cohort were utilized for *** Our research showed that most of the FRGs(85%)were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD *** FRGs were related to overall survival(OS)in the univariate Cox analysis(all P1,P<0.01).The predictive capacity of the model was verified by a receiver operating characteristic curve *** addition,a nomogram based on the expression of five hub FRGs and risk score can precisely predict the OS of individual COAD cancer p

关键词： colon adenocarcinoma Ferroptosis Immune status Prognosis Overall survival

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Metachronous isolated penile metastasis from sigmoid colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2022年第31期10卷 11658-11664页

作者： Guo-Lin Yin Jiang-Bo Zhu Cheng-Lin Fu Ru-Liang Ding Jun-Miao Zhang Qian Lin Department of Urology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Pathology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina Department of Anorectology Taizhou First People's HospitalTaizhou 318020Zhejiang ProvinceChina

BACKGROUND Sigmoid colon adenocarcinoma has a high incidence among gastrointestinal tumors,and it very rarely metastasizes to the *** literature reports that the prognosis after penile metastasis is generally poor,with a median survival of about 9 *** isolated metastasis to the penis originating from sigmoid colon adenocarcinoma has not been reported so ***,we report a case of sigmoid colon adenocarcinoma with isolated penile metastasis occurring 2 years after *** mass was pathologically confirmed as metastatic adenocarcinoma,and oral chemotherapy with capecitabine was given after *** tumor did not recur during the 2-year follow-up *** SUMMARY A 79-year-old man presented to the urology department with"a mass located at the root of the penis since 1 mo".Enhanced computed tomography(CT)examination suggested a 12 mm×10 mm×9 mm nodule at the root of the right penile corpus ***,pulmonary,and abdominal CT;and bone scan did not show any tumorigenic *** carcinoembryonic antigen(CEA)level was slightly elevated(6.01 ng/mL,reference value 0-5 ng/mL).The patient had undergone laparoscopic radical sigmoidectomy for sigmoid colon cancer 2 years *** postoperative pathology showed moderately differentiated adenocarcinoma of the sigmoid colon,and the stage was *** penile mass was removed under general *** postoperative pathology showed adenocarcinoma,and immunohistochemistry showed CDX2(+),CK20(+),and Villin(+).Based on the medical history,he was diagnosed with penile metastasis from sigmoid colon *** CEA level returned to normal(3.34 ng/mL)4 d after *** chemotherapy with capecitabine was given subsequently,and tumor recurrence was not found during the 2-year follow-up *** To our knowledge,this is a rare case of metachronous isolated penile metastasis from sigmoid colon *** penis is a potential site of metastasis of colon adenocarcinoma,an

关键词： colon adenocarcinoma Penis Metastases Metachronous adenocarcinoma Case report

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Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-Ying Zeng Zhi-Hong Yu Peng Shen Zheng-Quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same *** MPCs are rarer than solitary cancers or metachronous *** diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these *** SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory *** multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were *** on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 ***,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained *** Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma colon adenocarcinoma Cetuximab Chemotherapy Case report

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CHANGES OF NUCLEAR MATRIX PROTEIN AND ITS RELATIONSHIP WITH c-erbB-2 IN HUMAN colon adenocarcinoma

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Chinese Journal of Cancer Research 2005年第4期17卷 255-259页

作者：王娅兰高静李圆圆 Department of Pathology Chongqing University of Medical Sciences Department of Pathology Second Affiliated Hospital Chongqing University of Medical Sciences

Objective： Nuclear matrix protein is tissue, cell-type specific, and tumor-relative. It plays an important role in the regulation of intranuclear processes. Some researches also showed that a c-erbB-2 promoter-specific DNA-binding nuclear matrix protein is present only in malignant human breast tissues and induces mitogenesis and cell surface expression of the c-erbB-2 protein in resting NIH/3T3 cells. But it is not clear that how it in colon adenocarcinomas. Methods： Two-dimensional gel electrophoretic method was used for NMP identification and immunohistochemistry was used for c-erbB-2 detection in 12 cases of colon adenocarcinomas and matched adjacent normal colon tissues. Results： 5 different nuclear matrix proteins （named C1-C5） were identified in 12 colon adenocarcinoma specimens, but not in the matched adjacent normal colon tissues; 3 nuclear matrix proteins （named N1-N3） were identified in all 12 matched adjacent normal colon tissues, but not in colon adenocarcinoma specimens. A nuclear matrix protein （named N4） was detected in all of 9 moderated-well differentiated adenocarcinomas and all 12 matched adjacent normal colon tissues, but not in 3 poor-differentiated adenocarcinomas. All of the 10 colon adenocarcinomas which had the nuclear matrix protein C4 were c-erbB-2 expression positive. Conclusion： The data suggest that there are specific nuclear matrix proteins in colon adenocarcinomas and its subtypes, which maybe valuable to serve as markers of colon adenocarcinomas in future. Nuclear matrix protein C4 probably is a c-erbB-2 promotor-specific nuclear matrix protein in colon adenocarcinomas, and may induce the expression of c-erbB-2.

关键词： colon adenocarcinoma Nuclear matrix protein c-erbB-2 Two-dimensional gel electrophoresis

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colon adenocarcinoma in a Retrograde Intussusception: A Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 153-160页

作者： Carlos Hernández Brito Pedro Arredondo Ruiz Brenda Paola Sáenz Dávila Arsenio Torres Delgado Luis Eduardo Méndez Turrubiates Luis Ángel Amezcua Toledo Omar Josué Herrera López Surgical Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Clinical Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico General and Laparoscopic Surgery Corporativo M&#233dico-Quir&#250rgico Torres Veracruz Mexico Radiation Oncology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Radiology Department Centro Oncol&#243gico Onkolid Veracruz Mexico Anatomical Pathology Department Centro Oncol&#243gico Onkolid Veracruz Mexico

Background: Intussusception is defined as a telescoping of a proximal gastrointestinal segment with its mesentery to a distal one, only 5% occur in adults and in colon the probability that it is caused by a malignant disease is up to 65%. Only 1% occurs in a retrograde manner, the rest occur in an anterograde manner. Aim: Describe the clinical presentation of an intussusception in the adult patient as well as its most frequent causes and possible complications that influence decision making for a definitive treatment. Case Presentation: A 66-year-old woman diagnosed with colon adenocarcinoma who underwent elective transverse colectomy and colonic anastomosis with an incidental finding of a transverse colon tumor in a retrograde intussusception was studied. Conclusion: In any adult patient with an intussusception especially in colon a neoplasia should be suspected and the affected segment should be resected without being reduced due to the risk of perforation and tumor dissemination.

关键词： colon Cancer colon adenocarcinoma colonic Intussusception Intussusception

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Characterization of immunogenic cell death-related genes predicting prognosis in colon adenocarcinoma

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Medical Data Mining 2024年第4期7卷 19-27页

作者： Jie Chen Hong-Yi Zhou Fu-Yi Xie Laboratory Centre Li Huili HospitalNingbo Medical CentreNingbo 315040China Department of Anorectal Surgery Li Huili HospitalNingbo Medical CentreNingbo 315040China

Background:colon adenocarcinoma(COAD)is a gastrointestinal malignancy with a high mortality *** have confirmed the role of immunogenic cell death(ICD)in different cancer ***,there is a lack of research on ICD-related genes(ICD-RGs)in *** study aimed to examine the impact of ICD-RGs on COAD and their interaction with the immune ***:Using data from The Cancer Genome Atlas and Gene Expression Omnibus databases,we identified 107 ICD-RGs in *** a one-way Cox regression analysis,we examined the relationship between these ICD-RGs and overall survival in ***:Following the regression analyses,we identified 14 overall survival-related ***,we examined the predictive impact of the ICD-RGs using the least absolute shrinkage and selection operator regression analysis and developed a nine-genes prognostic *** Cancer Genome Atlas and Gene Expression Omnibus datasets were used for training and ***-Meier analysis was used to confirm that the high-risk group had a lower survival rate than the low-risk ***,following a multifactorial analysis,we created a prognostic nomogram that integrated clinical data and risk ***:The nine-genes model exhibits robust stability and can provide valuable insights for guiding the development of tumor immunotherapy strategies and personalized drug selection for patients with COAD.

关键词： colon adenocarcinoma least absolute shrinkage and selection operator prognosis immunogenic cell death-related genes

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Deciphering the Role of EPPK1 in the Development of colon adenocarcinoma by Integrated Bioinformatics Approach

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Journal of Clinical and Nursing Research 2024年第10期8卷 19-29页

作者： Muhammad Akram Muhammad Umair Abid Department of Microbiology King Saud UniversityRiyadh 11451Saudi Arabia Department of Plant Breeding and Genetics University of Agriculture FaisalabadFaisalabad 03802PunjabPakistan

The role of Epiplakin1(EPPK1)in colon adenocarcinoma(COAD)was analyzed through a comprehensive evaluation of its expression,methylation,genetic mutations,and prognostic implications.A significant up-regulation of EPPK1 expression in COAD malignant cells compared to normal control samples was observed using data from the UALCAN ***1 expression was found to be elevated across different cancer development stages,racial groups,genders,and age groups,emphasizing its crucial role in cancer *** of EPPK1 expression through the GEPIA2.0 dataset further confirmed its overexpression in COAD when compared to normal *** analysis revealed dysregulation across all four stages of cancer development,with the highest expression in stage IV and the lowest in stage ***,promoter methylation analysis demonstrated a fundamental relationship between COAD samples and normal controls,revealing significant methylation patterns across different clinical parameters,including cancer stages,race,gender,and *** survival(OS)and disease-free survival(DFS)analysis using the KM plotter showed a strong association between high EPPK1 expression and worse survival outcomes in COAD ***,low EPPK1 expression was linked to better OS and *** mutation analysis using cBioPortal identified minimal EPPK1 mutations in COAD,predominantly truncating and missense mutations,highlighting their relevance to EPPK1 dysregulation in *** findings underscore the important role of EPPK1 in COAD development and proliferation,suggesting its potential as a therapeutic target and prognostic *** exploration of EPPK1’s molecular mechanisms and its involvement in the COAD microenvironment may reveal new pathways for targeted treatments and precision medicine strategies against this challenging disease.

关键词： EPPK1 colon adenocarcinoma Biomarker Prognosis

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GINS1 as a Novel Biomarker of Survival in colon adenocarcinoma Patients-A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 60-67页

作者： Muhammad Umair Abid Yasir Hameed Department of Plant Breeding and Genetics University of Agriculture FaisalabadFaisalabadPakistan Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study focused on elaborating the role of GINS1 expression and its regulatory mechanisms in colon adenocarcinoma (COAD). Using the UALCAN informational index, GINS1 expression assessment unveiled a critical up- regulation in malignant cells that stood out from normal controls, suggesting its contribution to COAD expansion. Further dismantling GINS1 expression across various boundaries revealed unsurprising up-regulation in different malignant development stages, racial groups, genders, and age classes in COAD patients, characteristics for its imperative role in cancer progression. Moreover, this study investigated the promoter methylation status of GINS1, uncovering a critical uniqueness between COAD samples and normal controls. Analyzing promoter methylation across various clinical boundaries uncovered powerful variations, with particular methylation patterns seen across cancer stages, race groups, genders, and age groups. Survival analysis using the Kaplan-Meier (KM) plotter tool showed a colossal connection between GINS1 expression levels and overall survival (OS) in COAD patients, with low GINS1 expression interfacing with higher OS. Additionally, mutational examination using the cBioPortal stage revealed that no critical change was found in COAD. Overall, these findings revealed the complex contribution of GINS1 in COAD pathogenesis, underlining its actual limit as a prognostic biomarker and supportive therapeutic agent in COAD management.

关键词： colon adenocarcinoma Diagnosis Treatment

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Prognostic significance of CDKN2A expression in colon adenocarcinoma: insights from TCGA analysis

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Cancer Advances 2024年第16期7卷 1-10页

作者： Wei Fu Yao Wang Qin-Ming Yan Guo-Bin Cheng Lin-Ya Lyu Yao Ding Department of Gastroenterology 925th Hospital of Joint Logistics Support Force of People’s Liberation Army of ChinaGuiyang 510009China

Background:The cyclin-dependent kinase inhibitor 2a(CDKN2A)gene,identified as the multiple tumor suppressor gene,functions as a regulatory gene implicated in cancer *** significance lies in its pivotal involvement in the genesis of various tumors;notwithstanding,the precise connection between CDKN2A and c olon adenocarcinoma(COAD)remains ***:The objective of this research was to assess the predictive importance of CDKN2A in COAD by analyzing data from The Cancer Genome Atlas *** regression,signed rank test,Wilcoxon test,and Kruskal-Wallis test were used to examine CDKN2A expression levels and clinicopathological *** and multivariate Cox r egression analyses and Kaplan-Meier analysis found prognostic ***,gene set enrichment analysis identified key CDKN2A expression *** study additionally examined CDKN2A expression with tumor immune infiltration using The Cancer Genome Atlas data and single sample gene set enrichment ***:The results of this investigation indicated a substantial connection between higher CDKN2A expression and negative outcomes in terms of overall survival and disease-related survival among COAD *** set enrichment analysis indicated a tight link between CDKN2A and both the cell cycle and hedgehog signaling *** evaluation employing single sample gene set enrichment analysis demonstrated a positive link between CDKN2A expression with infiltration by iDCs,whereas a negative correlation was detected with infiltration by helper T ***:In conclusion,the present study gives strong data supporting the predictive value of CDKN2A and its possible usefulness as a biomarker for ***,our results show a reasonable link between CDKN2A expression and immune influx in COAD,putting light on the role of CDKN2A in the control of the tumor ***,additional studies are needed to confirm the underlying m

关键词： CDKN2A colon adenocarcinoma immune infiltration prognostic analysis helper T cells

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Unusual Spreading of colon adenocarcinoma into the Right Hip Area: A Case Report

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Journal of Cancer Therapy 2012年第6期3卷 985-988页

作者： Renata Dobrila Dintinjana Duska Petranovic Gorazd Pilcic Vjekoslav Ilijic Davor Petranovic Marijan Dintinjana Department of Oncology University Hospital Center RijekaRijekaCroatia Department of Internal Medicine University Hospital Center RijekaRijekaCroatia Department of Internal Medicine Salem HospitalBernSwitzerland Department of Radiology Medico PolyclinicRijekaCroatia Private Clinic of Dr.Dintinjana RijekaCroatia.

adenocarcinoma is the most common colon cancer type. This form of colonic neoplasms usually metastasizes initially to regional lymphatic system and through the blood circulation to the lungs and liver, while other forms of expansion and involvement of other organ systems are less common. Extraluminal carcinoma is very rare. Only a few authors describe the direct spread of cancer to adjacent structures and organs. In this paper we present a case of a 76-year old patient with tumor mass extending from the colon to the right hip area “per continuitatem”. The patient had no symptoms and signs that would indicate the presence of neoplastic process in the colon. Only a discomfort in right leg was present and finally tumor mass was visualized. Biopsy and patohistology findings confirmed final diagnosis and type of tumor in the right hip region. Pathohistologicaly tumor was adenocarcinoma.

关键词： colon adenocarcinoma Local Spreading Right Hip

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