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World Journal of Gastroenterology 2018年第32期24卷 3671-3676页

作者： Ke-Xin Wang Zhi-Qiang Cheng Zhi Liu Xiao-Yang Wang Dong-Song Bi Department of General Surgery Qilu Hospital of Shandong University

AIM To investigate the vascular anatomy of inferior mesenteric artery(IMA) in laparoscopic radical resection with the preservation of left colic artery(LCA) for rectal cancer. METHODS A total of 110 patients with rectal cancer who underwent laparoscopic surgical resection with preservation of the LCA were retrospectively reviewed. A 3 D vascular reconstruction was performed before each surgical procedure to assess the branches of the IMA. During surgery, the relationship among the IMA, LCA, sigmoid artery(SA) andsuperior rectal artery(SRA) was evaluated, and the length from the origin of the IMA to the point of branching into the LCA or common trunk of LCA and SA was measured. The relationship between inferior mesenteric vein(IMV) and LCA was also evaluated.RESULTS Three vascular types were identified in this study. In type A, LCA arose independently from IMA(46.4%, n = 51); in type B, LCA and SA branched from a common trunk of the IMA(23.6%, n = 26); and in type C, LCA, SA, and SRA branched at the same location(30.0%, n = 33). The difference in the length from the origin of IMA to LCA was not statistically significant among the three types. LCA was located under the IMV in 61 cases and above the IMV in 49 cases. CONCLUSION The vascular anatomy of the IMA and IMV is essential for laparoscopic radical resection with preservation of the LCA for rectal cancer. To recognize different branches of the IMA is necessary for the resection of lymph nodes and dissection of vessels.

关键词： Inferior mesenteric artery Left colic artery Rectal cancer Laparoscopic

Renal colic: Epidemiological, Clinical Etiological and Therapeutic Aspects at the Urology Department of the National Reference General Hospital of N’Djamena (Chad)

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Open Journal of Urology 2020年第2期10卷 25-33页

作者： Mahamat Ali Mahamat Alkadri Diarra Amadou Kassogué Divine Eyongeta Vadandi Valentin Ndormadjita Allah-Syengar Koldimadji Mingué Ramat Wakamadja Moussa Kalli Okim Ahmat Kimassoum Rimtebaye University of N’Djamena and the National General Reference Hospital of N’Djamena (NGRH) N’Djamena Chad Urology Department Luxembourg University Teaching Hospital of Bamako Bamako Mali Urology Department Pr Bocar Sidi Sall University Teaching Hospital of Kati Kati Mali Urology Division Department of Surgery Regional Hospital Limbe Limbe Cameroon

Introduction: Renal colic is a medico-surgical emergency in which complicated forms could progress to renal failure and nonfunctional kidney. The objective of our study is to describe the epidemiological, diagnostic and therapeutic aspects of renal colic at the urology department of the NGRH. Methods: This was a prospective study involving 101 patients followed up for renal colic. The study spanned from July 2015 to July 2016 at the urology department of the NGRH. Results: A total of 101 patients suffering from renal colic were enrolled in the study giving a prevalence of 5.1%. The mean age was 38.89 years with a standard deviation of 14.5 years and a sex ratio of 1:3. Flank or lumbar pain of crushing type (45.5%), constant and of severe intensity (61.4%) were the most frequent clinical characteristics. The plain abdominal radiography (Kidney-Ureter-Bladder) coupled with ultrasonography had a 100% sensitivity for the etiological diagnosis of renal colic. Urinary lithiasis was the most frequent cause with 73.3%. Uroculture revealed a urinary tract infection in 44 patients (43.6%). The most frequent germ isolated on the culture was Escherichia coli (27.7%). Renal function was abnormal in 34 patients (33.7%). Medical treatment was composed of analgesics, NSAIDs and antispasmodic representing 93.1%. Percutaneous nephrostomy was performed in 6.9%. Pyelolithotomy was the most frequently performed surgical procedure and was done in 11 patients that are 39.3%. Fifty seven patients (56.4%) got healed without sequelae;6 cases (5.9%) of recurrence and 2 deaths (2%) were recorded. Conclusion: Renal colic is common in urology. Urinary lithiasis was the major cause in our series. Renal function could be endangered in case of late management.

关键词： Renal colic Lithiasis Bilharziasis NGRH Chad

Colo-colic Invagination on Lipoma

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Surgical Science 2017年第4期8卷 191-195页

作者： Eddy Oleko Ekuke Pierlesky Elion Ossibi Ouadii Mouaqit El Bachir Benjelloun Hicham El Bouhaddouti Boubacar Efared Laila Chbani Abdelmalek Ousadden Khalid Mazaz Khalid Ait Taleb Visceral Surgery Department Hassan II University Hospital Fez Morocco Anatomy and Pathological Cytology Department Hassan II University Hospital Fez Morocco

Intussusception in adults is rare and accounts for 1% to 5% of cases of acute bowel obstruction. Moreso, colic intussusception remains exceptional in adults and is usually secondary to an endoluminal lesion. Abdominal intestinal lipomas are rarely responsible for colonic invagination. They are often located on the caecum or the ascending colon and rarely on the left colon. We report the case of colo-colic invagination on a descending colon lipoma in a 50-year-old woman.

关键词： Bowel Obstruction colic Lipoma Intussusception Surgery

CLINICAL OBSERVATION ON AURICULAR POINT TREATMENT FOR 144 CASES OF BILIARY colic

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World Journal of Acupuncture-Moxibustion 1996年第2期6卷 23-25页

作者：胡宝生王尚全卢秀珍

In this study, 144 cases of biliary colic were treated by injecting Atropine in the auricu-lar points (Liver, Gallbladder). Among the 144 cases, 130 cases were markedly effective, 11 cases ef-fective and 3 cases ineffective, with the effective rate being 97. 90%. The results showed that therewas no difference between colic degrees, ages and analgesic effects. But analgesic effects for biliary as-cariosis and cholecystitis, cholelithiasis are much better than choledochal calculus (P<0.01).

关键词： Biliary colic Auricular point therapy Diseases of gallbladder tract

Anomalous origin and vulnerable course of left colic artery in relation to the pancreas—A case report

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Forensic Medicine and Anatomy Research 2013年第4期1卷 83-86页

作者： Satheesha Badagabettu Nayak Surekha Devadasa Shetty Srinivasa Rao Sirasanagandla Ashwini Aithal Swamy Ravindra Shanthakumar Melaka Manipal Medical College (Manipal Campus) Manipal University Manipal India

We report here an anomalous origin and course of left colic artery in relation to pancreas during routine dissection of the abdominal region in a 70-year-old male cadaver in the department of anatomy. The anomalous left colic artery took its origin from the superior mesenteric artery and immediately divided into right and left branches. The right branch passed through the transverse mesocolon to supply the left one third of the transverse colon. The left branch traversed to the left along the inferior border of the body of the pancreas and crossed the left kidney before supplying the left colic flexure of colon and descending colon. This aberrant course of the left branch of the left colic artery can be considered as a “vulnerable” course as it is liable to injury during pancreatic and renal surgeries since the artery is not expected to run along the inferior border of the pancreas. The pancreas, a retroperitoneal organ, is related to major arteries such as abdominal aorta, inferior vena cava, coeliac trunk and its main branches, superior mesenteric vessels, splenic and portal veins. Surgery of the pancreas therefore, not only needs a thorough knowledge of the normal course of branches of these vessels but also demands a good knowledge of possible anomalous vessels arising in this region.

关键词： Left colic Artery Pancreas Inferior Mesenteric Artery Superior Mesenteric Artery

Electroacupuncture Treatment of 50 Patients with Renal colic

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Journal of Acupuncture and Tuina Science 2003年第3期1卷 33-34页

作者： ZOU Lan-lin The Third People's Hospital of Jingdezhen Municipal Jiangxi 333001 China

Treated 50 cases of renal colic with electroacupuncture and compared the results with those in two control groups. Total effective rate in the treatment group, control group Ⅰ and control group Ⅱ was 98.0%,90.0% and... 详细信息

关键词： Electroacupuncture Renal colic Ureterolith

Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

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World Journal of Gastroenterology 2019年第34期25卷 5017-5025页

作者： Jeremy Meyer Surennaidoo Naiken Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frédéric Ris Division of Digestive Surgery University Hospitals of Geneva

Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last years.The use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be abandoned.The role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or enema.In parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome analysis.AL can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical strategies.Implementation of fluorescence angiography should be encouraged.Progress made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications.

关键词： Anastomotic leakage Rectal surgery colic surgery Prevention Surgical site infection Anastomosis Complication

Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis

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World Journal of Gastroenterology 2019年第5期25卷 539-551页

作者： Tilemachos Koutouratsas Theodora Kalli Georgios Karamanolis Maria Gazouli Department of Basic Medical Science Laboratory of Biology School of Medicine University of Athens Gastroenterology Department Larnaca General Hospital Gastroenterology Unit 2nd Department of Surgery "Aretaieio"University Hospital School of Medicine University of Athens

Functional gastrointestinal disorders(FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin's relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate.

关键词： Functional gastrointestinal disorders Functional colonic diseases Irritable bowel syndrome Cyclic vomiting syndrome Infantile colic Gastrointestinal disease Ghrelin Genetics Epigenetic processes

Hypoallergenic formula with Lactobacillus rhamnosus GGfor babies with colic:A pilot study of recruitment,retention,and fecal biomarkers

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World Journal of Gastrointestinal Pathophysiology 2016年第1期7卷 160-170页

作者： Nicole Y Fatheree Yuying Liu Michael Ferris Melissa Van Arsdall Valarie McMurtry Marcela Zozaya Chunyan Cai Mohammad H Rahbar Manouchehr Hessabi Ta Vu Christine Wong Juleen Min Dat Q Tran Fernando Navarro Wallace Gleason Sara Gonzalez J Marc Rhoads Department of Pediatrics the University of Texas Health Science Center at Houston Medical SchoolHoustonTX 77030United States Biostatistics/Epidemiology/Research Design Core Center for Clinical and Translational Sciencesthe University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Epidemiology Human Genetics and Environmental Sciencesthe University of Texas School of Public Health at HoustonHoustonTX 77030United States Department of Pediatrics Louisiana State University Health Science Center and the Research Institute for ChildrenNew OrleansLA 70112United States Investigational Drug Services Pharmacy Memorial Hermann HospitalHoustonTX 77030United States

AIM To investigate recruitment, retention, and estimatesfor effects of formula supplementation withLactobacillus rhamnosus GG （LGG） on inflammatorybiomarkers and fecal microbial community in infants withcolic.METHODS： A prospective, double-blind, placebocontrolledtrial was conducted in otherwise healthyinfants with colic. We screened 74 infants and randomizedand analyzed results in 20 infants [9 receivingLGG （LGG＋） and 11 not receiving LGG （LGG-）]. LGG wasincorporated in the formula （Nutramigen？）（minimum of3 × 10^7 CFU/d） in the LGG＋ group. Fecal microbiota andinflammatory biomarkers, including fecal calprotectin（FC）, plasma cytokines, circulating regulatory T cells（Tregs）, and crying ＋ fussing time were analyzed todetermine optimal time points and effect sizes for alarger trial.RESULTS： Recruitment in this population was slow, withabout 66% of eligible infants willing to enroll; subjectretention was better （75%）. These rates were influencedby parents＇ reluctance to volunteer their infant for aclinical trial and by their tendency to change formulas.The maximal difference of crying ＋ fussing time wasobserved at day 14, comparing the 2 groups, with amean difference of -91 （95%CI： -76, 259） min （P = NS）.FC showed no significant difference, but the optimaltime to determine a potential effect was at day 90 [witha mean difference of 121 （95%CI： -48, 291） μg/g stool],observing a lower level of FC in the LGG＋ group. Thefecal microbial communities were chaotic, as determinedby Shannon＇s diversity index and not apparently influencedby the probiotic. No significant change wasobserved in plasma inflammatory cytokines or Tregs,comparing LGG＋ to LGG- groups.CONCLUSION： Designing future colic trials involving aprobiotic-supplemented formula for infants in the UnitedStates will require consideration for difficult enrollment.Infants with colic have major variations in feal microbiotaand calprotectin, both of which improve with time, withoptimal time points for measurement at days 14 and 90after treatment.

关键词： Barr diary Regulatory T cells Cytokines Crying Fussing Probiotic Inflammation Biomarker Newborn Intestine Fatheree NY et al . Probiotic formula for infants with colic

Acute pain management in symptomatic cholelithiasis

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World Journal of Gastrointestinal Surgery 2016年第10期8卷 713-718页

作者： Tahir Masudi Helen Capitelli-Mc Mahon Suhail Anwar York Hospitals NHS Foundation Trust the York Teaching Hospital

AIM To review the evidence for the use of different nonsteroidal anti-inflammatory drugs(NSAIDs) in the treatment of biliary colic.METHODS The strategies employed included an extensive literature review for articles and studies related to biliary colic from electronic databases including Pub Med,Science Direct,Wiley Inter Science,Medline and Cochrane from last 15 years.Keywords: "Biliary colic","management of biliary colic","non-steroidal anti-inflammatory drugs","cholelithiasis" and "biliary colic management".Six randomized control trials,1 non-randomized trial and 1 meta-analysis were included in this review.The outcomes of these studies and their significance have been reviewed in this paper.RESULTS Current evidence suggests there are no set protocols for biliary colic pain management.NSAIDs are potent in the management of biliary colic,not only in terms of symptom control but in disease progression as well.Apart from the studies on diclofenac and ketorolac,there are studies which have shown that intravenous tenoxicam and injectable flurbiprofen are equally effective in managing biliary colic.The efficacy of NSAIDs is superior in terms of lower number of doses and longer duration of action in comparison to other analgesic agents.CONCLUSION This literature review has found that NSAIDs are safe and effective for pain control in biliary colic,and reduce the likelihood of further complications.

关键词： Biliary colic Management of biliary colic Non-steroidal anti-inflammatory drugs Cholelithiasis Biliary colic management