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Effects of a Cocktail Supplement of Ginkgo Biloba and Acai Extract on cognitive symptoms of Parkinson’s Disease

Advances in Parkinson's Disease 2024年第3期13卷 57-72页

作者： Yulia Dubrovensky Boston University Boston MA USA

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Current treatments often involve synthetic drugs with significant side effects and potential for dependency. This study investigates the effects of a natural supplement combination of Ginkgo Biloba and Acai Extract on cognitive symptoms in a 77-year-old male with PD. The participant underwent a three-month supplementation regimen, with cognitive function assessed using the Montreal cognitive Assessment (MoCA) test before and after the intervention. The results indicated an improvement in cognitive scores, suggesting that the combination of Ginkgo Biloba and Acai Extract may offer a promising alternative or adjunct to conventional PD treatments. This study highlights the potential of natural supplements in managing PD symptoms and calls for further research with larger sample sizes to confirm these findings. Human data was performed in accordance with the Declaration of Helsinki by the Roxbury District IRB Board (IRB Number: IRB00011767).

关键词： Parkinson’s Disease (PD) cognitive Function Ginkgo Biloba Acai Extract Neurodegenerative Disorders Natural Supplements cognitive symptoms Montreal cognitive Assessment (MoCA) Dopaminergic Neurons Antioxidants Neuroprotection Non-Motor symptoms Oxidative Stress Polyphenols

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Neuropsychiatric disorders and cognitive dysfunction in patients with Cushing＇s disease

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Chinese Medical Journal 2013年第16期126卷 3156-3160页

作者： CHEN Yu-fan LI Yun-feng CHEN Xiao SUN Qing-fang Department of Neurosurgery Ruijin Hospital Affiliated Hospital ofShanghai Jiaotong University Shanghai 200025 China

Objective To review the main neuropsychiatric disorders and cognitive deficits in patients with Cushing＇s disease （CD） and the associated pathophysiological mechanisms underlying *** mechanistic details may provide recommendations for preventing or treating the cognitive impairments and mood disorders in patients with *** sources Data were obtained from papers on psychiatric and cognitive complications in CD published in English within the last 20 *** perform the PubMed literature search,the following keywords were input：cushing＇s disease,cognitive,hippocampal,or *** selection Studies were selected if they contained data relevant to the topic addressed in the particular *** of the limited length of this article,we have frequently referenced recent reviews that contain a comprehensive amalgamation of literature rather than the actual source *** Patients with active CD not only suffer from many characteristic clinical features,but also show some neuropsychiatric disorders and cognitive *** the psychiatric manifestations,the common ones are emotional instability,depressive disorder,anxious symptoms,impulsivity,and cognitive *** effects of previous glucocorticoid （GC） excess on the central nervous system,such as hippocampal and the basal ganglia,is the most reasonable *** secretion of cortisol brings much structural and functional changes in hippocampal,such as changes in neurogenesis and morphology,signaling pathway,gene expression,and glutamate *** volume loss can be found in most patients with CD,and decreased glucose utilization caused by GCs may lead to brain atrophy,neurogenesis impairment,inhibition of long-term potentiation,and decreased neurotrophic factors; these may also explain the mechanisms of GC-induced brain atrophy and hippocampal *** Brain atrophy and hippocampal changes caused by excess secretion of cortisol are thoug

关键词： cushing's disease psychology cognitive symptoms hippocampal glucocorticoids

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