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cochlear synaptopathy Following Noise Exposure in Guinea Pigs: Its Electrophysiological and Histological Assessments

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Sound & Vibration 2020年第3期54卷 163-177页

作者： Parvane Mahdi Akram Pourbakht Vahid Pirhajati Mahabadi Alireza Karimi Yazdi Mahtab Rabbani Anari Mohammad Kamali Rehabilitation Research Center Department of AudiologySchool of Rehabilitation SciencesIran University of Medical SciencesTehran15459-13487Iran Department of Neurosciences School of MedicineIran University of Medical SciencesTehran14496-14535Iran Department of Otorhinolaryngology Tehran University of Medical SciencesTehran14197-33141Iran Department of Rehabilitation Management Iran University of Medical SciencesTehran15459-13487Iran

Exposure to high level of noise,may cause the permanent cochlear synaptic *** present study,a model of noise induced cochlear synaptopathy was established and the electrophysiological and histological metrics for its assessment was designed.6 guinea pigs were subjected to a synaptopathic noise(octave band of 4 kHz at 104 dB SPL,for 2-h).The amplitude growth curve of Auditory Brainstem Response(ABR)wave-I and wave-III latency shift in presence of noise were *** indexes were considered in pre-exposure,1 day post exposure(1DPE),1 week post exposure(1WPE)and 1 month post exposure(1MPE)to ***,the samples were histologically *** wave-I amplitude was different between pre and 1DPE(p-value≤0.05).However,at 1WPE,it was recovered at low intensities but at 70 dB SPL and above,the differences persisted even till *** masked ABR,the latency shift of wave-III was different between pre and 3 post exposure assessments(p-value≤0.05).Electro-microscopic analysis confirmed the synaptic degeneration,as the ribbons were larger than normal,hollow inside,and spherical and irregular in shape,also,the post synaptic density was abnormally thick and missed its flat *** data revealed that noise at level below that can produce permanent hearing loss,can incur synaptic ***,noise is considered to be more damaging than previously ***,designing tools for clinical assessment of synaptopathy is beneficial in comprehensive auditory evaluation of those with history of noise exposure and also in hearing protection planning.

关键词： cochlear synaptopathy noise induced hearing loss hidden hearing loss excitotoxicity hearing protection

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Subclinical hearing loss associated with aging

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Journal of Otology 2023年第3期18卷 111-117页

作者： Cristian Aedo-Sanchez Jose Oliveros Constanza Aranguiz Camila Munoz Claudia Lazo-Maturana Enzo Aguilar-Vidal Departamento de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile

Objective:Contribute to clarifying the existence of subclinical hearing deficits associated with ***:In this work,we study and compare the auditory perceptual and electrophysiological performance of normal-hearing young and adult subjects(tonal audiometry,high-frequency tone threshold,a triplet of digits in noise,and click-evoked auditory brainstem response).Study sample:45 normal hearing volunteers were evaluated and divided into two groups according to age.27 subjects were included in the“young group”(mean 22.1 years),and 18 subjects(mean 42.22 years)were included in the“adult group.”Results:In the perceptual tests,the adult group presented significantly worse tonal thresholds in the high frequencies(12 and 16 kHz)and worse performance in the digit triplet tests in *** the electrophysiological test using the auditory brainstem response technique,the adult group presented significantly lower I and V wave amplitudes and higher V wave latencies at the supra-threshold *** the threshold level,we observed a significantly higher latency in wave V in the adult *** addition,in the partial correlation analysis,controlling for the hearing level,we observed a relationship(negative)between age and speech in noise performance and high-frequency *** significant association was observed between age and the auditory brainstem ***:The results are compatible with subclinical hearing loss associated with aging.

关键词： Age-related hearing loss cochlear synaptopathy Auditory electrophysiology Speech perception Aging

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