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Progress in bioactive surface coatings on biodegradable Mg alloys:A critical review towards clinical translation

Bioactive Materials 2023年第1期19卷 717-757页

作者： Navdeep Singh Uma Batra Kamal Kumar Neeraj Ahuja Anil Mahapatro Department of Metallurgical and Materials Engineering Punjab Engineering CollegeChandigarh160012India Department of Mechanical Engineering Punjab Engineering CollegeChandigarh160012India Department of Biomedical Engineering Wichita State UniversityWichitaKS67260United States

Mg and its alloys evince strong candidature for biodegradable bone implants,cardiovascular stents,and wound closing ***,their rapid degradation rate causes premature implant failure,constraining clinical ***-functional surface coatings have emerged as the most competent strategy to fulfill the diverse clinical requirements,besides yielding effective corrosion *** article reviews the progress of biodegradable and advanced surface coatings on Mg alloys investigated in recent years,aiming to build up a comprehensive knowledge framework of coating techniques,processing parameters,performance measures in terms of corrosion resistance,adhesion strength,and *** developed conversion and deposition type surface coatings are thoroughly discussed by reporting their essential therapeutic responses like osteogenesis,angiogenesis,cytocompatibility,hemocompatibility,anti-bacterial,and controlled drug release towards in-vitro and in-vivo study *** challenges associated with metallic,ceramic and polymeric coatings along with merits and demerits of various coatings have been *** use of multilayered hybrid coating comprising a unique combination of organic and inorganic components has been emphasized with future perspectives to obtain diverse bio-functionalities in a facile single coating system for orthopedic implant applications.

关键词： Mg alloys Corrosion resistance Bio-functionality Conversion coating Multilayered hybrid coating coating failures

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