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Prognostic significance of preoperative lymphocyte to monocyte ratio in patients with signet ring gastric cancer

世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1673-1683页

作者： He-Li Liu Xiang Feng Mi-Mi Tang Hai-Yan Zhou Huan Peng Jie Ge Ting Liu Department of Gastrointestinal Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal Tumor The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal TumorChangsha 410008Hunan ProvinceChina Institute for Rational and Safe Medication Practices National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Clinical Nursing Teaching and Research Section Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND The ratio of lymphocytes to monocytes(LMR)has been shown to be an effective predictor of gastric cancer ***,its predictive accuracy for signet ring gastric cancer is currently not well *** To evaluate the prognosis predictive accuracy of preoperative LMR in signet ring gastric *** A total of 212 signet ring gastric cancer patients admitted at the Xiangya Hospital of Central South University,Department of Gastrointestinal Surgery,from January 2012 to December 2016 were enrolled in the *** prognosis predictive accuracy of preoperative LMR was explored based on the area under the receiver operating *** that significantly affect the survival of patients were identified using single factor analysis,and those that were independently associated with signet ring gastric cancer were identified through multivariate *** The results of the single factor analysis revealed a strong correlation between the survival of signet ring gastric cancer patients and several factors,including tumor invasion(χ^(2)=49.726;P<0.001),lymph node metastasis(χ^(2)=30.269;P<0.001),pTNM stage(χ^(2)=49.322;P<0.001),surgical approach(χ^(2)=8.489;P=0.004),age(t=-2.213;P<0.028),carcinoembryonic antigen(CEA)(Z=-3.265;P=0.001),platelet-to-lymphocyte ratio(Z=-2.196;P=0.028),LMR(Z=-2.226;P=0.026),ALB(t=3.284;P=0.001),prognostic nutritional index(t=-3.789;P<0.001)and FIB(Z=-3.065;P=0.002).Furthermore,the multivariate analysis further demonstrated that age(HR:0.563,95%CI:0.363-0.873),tumor invasion depth(HR:0.226,95%CI:0.098-0.520),pTNM stage(HR:0.444,95%CI:0.255-0.771),preoperative CEA level(HR:0.597,95%CI:0.386-8.790),and preoperative LMR level(HR:1.776,95%CI:1.150-2.741)were independent factors influencing the prognosis of signet ring gastric *** In signet ring gastric cancer patients,a low preoperative LMR level predicts poor *** death risk ratio of the low LMR group compared to the high LMR group i

关键词： Gastric cancer Signet ring cell carcinoma Inflammation indexes coagulation indexes Prognosis

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