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Vascular Endothelial Growth Factor and cluster of differentiation 34 for Assessment of Perioperative Bleeding Risk in Gastric Cancer Patients

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Chinese Medical Journal 2016年第16期129卷 1950-1954页

作者： Mu-Qing He Mu-Qun He Jian-Feng Wang Bao-Ling Zhu Ni Sun Xiao-Hai Zhou Rong-Xin Yao Department of Hematology and Medical Oncology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China Department of Medical Oncology Fujian Provincial Tumor Hospital Fuzhou Fujian 350014 China

Background： Angiogenesis is the formation of new blood vessels to supply nutrients to tumors. Vascular endothelial growth factor （VEGF） and cluster of differentiation 34 （CD34） are important signaling proteins involved in angiogenesis. Many studies have demonstrated that VEGF and CD34 are related to tumor progression. This study focused on the relationship between VEGF, CD34, and perioperative hemorrhage in patients with gastric cancer. Methods： To observe the relationship between VEGF and CD34, we tracked 112 patients with advanced gastric cancer for 5 years to assess factors related to hemorrhage, using immunohistochemistry. The results were subjected to statistical analysis using a 2 × 2 contingency table, logistic regression, and receiver operating characteristic （ROC） test. Results： The concentrations of VEGF and CD34 were critically correlated with perioperative hemorrhage and neural invasion in patients with gastric cancer （P 〈 0.05）. Expression of VEGF and CD34 was related （P 〈 0.05, χ2 = 6.834）. VEGF and CD34 co-expression strongly increased the risk of preoperative bleeding （area under the ROC curve 〉0.7, P 〈 0.05）. Conclusions： Expression of VEGF and CD34 was critically correlated with perioperative hemorrhage in gastric cancer patients. Co-expression of VEGF and CD34 could be an effective indicator for evaluating the risk ofperioperative bleeding in gastric cancer patients.

关键词： cluster of differentiation 34 Gastric Cancer Neural Invasion Perioperative Hemorrhage Vascular Endothelial GrowthFactor

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Intracranial malignant solitary fibrous tumor metastasized to the chest wall:A case report and review of literature

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World Journal of Clinical Cases 2020年第20期8卷 4844-4852页

作者： Daisuke Usuda Shinya Yamada Toshihide Izumida Ryusho Sangen Toshihiro Higashikawa Ken Nakagawa Masaharu Iguchi Yuji Kasamaki Department of General Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan Department of Infectious Diseases Kanazawa Medical UniversityUchinadamachi 920-0293Ishikawa-kenJapan Department of Respiratory Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan Department of Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

BACKGROUND Solitary fibrous tumor(SFT)is a rare fibroblastic mesenchymal neoplasm that affects spindle cell soft tissues with broad-spectrum biological behavior;it is predominantly benign,and rarely *** occurs mainly in the tissue structure of the serosa in the pleura and the thorax,and can be found throughout the body,though extra-thoracic localization,including the cephalic region,is *** reported the first case of intracranial malignant SFT metastasized to the chest *** SUMMARY An 81-year-old Japanese man was referred to our hospital due to progressive gait disturbance and appetite *** medical history included partial resection due to brain tumor,four times,and 50-Gray radiation therapy at another hospital,starting when he was 74 years *** unenhanced head computed tomography(CT)scan revealed an 8 cm×5.1 cm×6.5 cm mixed-density mass at the left frontal lobe,accompanying a midline shift,and an unenhanced chest-abdomen CT scan revealed a 6 cm×4.1 cm×6.5 cm low-density mass in the left chest wall.A CT-guided percutaneous lung biopsy was performed,and the pathological findings were SFT corresponding to brain ***,the correct diagnosis of his brain tumor in history of past illness revealed to be SFT,and the unremovable tumor,namely present brain lesions enlarged and metastasized to the chest *** established a definitive diagnosis of intracranial malignant SFT metastasized to the chest *** notified him and his family of the disease,and offered palliative *** passed away on the 29 th hospital *** This case suggests the need for careful,detailed examination,and careful followup when encountering patients presenting with a mass.

关键词： Solitary fibrous tumor Intracranial malignant solitary fibrous tumor Metastasized chest wall tumor cluster of differentiation 34 STAT6 Case report

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