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Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by clonorchis sinensis infection

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World Journal of Clinical Cases 2021年第23期9卷 6639-6653页

作者： Xin-He Zhang Die Huang Yi-Ling Li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

clonorchis sinensis infection is still a major public health *** is estimated that more than 15 million people worldwide are infected,especially in Northeast China,Taiwan,South Korea,and North *** detection of clonorchis sinensis eggs in feces and bile is still the only gold standard for the diagnosis of clonorchis sinensis infection,and new detection methods are needed to improve the detection *** clonorchis sinensis invades the human body,it mainly parasitizes the hepatobiliary ***,it is closely related to hepatobiliary diseases such as cholangitis,bile duct stones,liver fibrosis,and *** increase in immunoglobulin G4(IgG4)caused by clonorchis sinensis infection is rare and there are few reports about the relevant *** may be related to the inflammatory factors interleukin(IL)-4,IL-10,and IL-13 produced by human phagocytes,T cells,B cells,and other immune cells in the process of resisting the invasion of clonorchis ***,this finding still needs further clarification and *** article reviews the epidemiology,clinical manifestations,serology,imaging,pathogenic mechanism,and control measures of clonorchis sinensis infection to help establish the diagnostic process for clonorchis *** report novel mechanisms of IgG4 elevation due to clonorchis sinensis infection to provide more experience and a theoretical basis for clinical diagnosis and treatment of this infection.

关键词： Liver damage Bile duct damage Hepatobiliary system destruction clonorchis sinensis infection Immunoglobulin G4 Clinical manifestations

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