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Clinical and epidemiological features of patients with clonorchiasis

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World Journal of Gastroenterology 2004年第3期10卷 446-448页

作者： Ke-XiaWang Rong-BoZhang Yu-BaoCui YeTian RuCai Chao-PinLi DepartmentofEtiologyandImmunology SchoolofMedicineAnhuiUniversityofScienceandTechnologyHuainan232001AnhuiProvinceChina

AIM:To study the clinical and epidemiological features of patients with clonorchiasis so as to provide scientific evidences for the diagnosis and prevention of clonorchiasis. METHODS:Stools from 282 subjects suspected of having clonorchiasis were examined for helminth eggs with modified Kato's thick smear and sedimentation methods,and their sera were tested for HAV-DNA,HBV-DNA,HCV-RNA,HDV- RNA and HEV-RNA with polymerase chain reaction (PCR). Clinical symptoms of patients with clonorchiasis only were analyzed,and their blood samples were tested for circulating antigen (CAg) with Dot-ELISA,esoinophilic granulocyte count, and alanine aminotransferase (ALT).Meanwhile,they were asked to provide data of occupation,eating habit,hygienic habit and knowledge of *** addition,the ecosystem of the environment in epidemic areas was surveyed. RESULTS:Among the 282 patients,61 (21.43%) were infected with clonorchis sinensis only,97 (34.64%) were co-infected with clonorchis sinensis and other pathogens, 92 (32.86%) were infected with hepatitis virus only and 31 (11.07%) neither with clonorchis sinensis nor hepatitis virus. Among the 61 patients with clonorchiasis only,there were 14 (22.95%) subjects with discomfort over hepatic region or epigasfrium,12 (19.67%) with general malaise or discomfort and inertia in total body,6 (9.84%) with anorexia,indigestion and nausea,4 (6.56%) with fever,dizziness and headache (6.56%),and 25 (40.98%) without any symptoms;sixty one (100%) with CAg (+),98.33% (59160) with eosinophilic granulocytes increased and 65.00% (39/60) with ALT increased.B-mode ultrasonography revealed 61 cases with dilated and thickened walls of intrahepatic bile duct,and blurred patchy echo acoustic image in ***-six cases had stones in the bile duct,39 cases had slightly enlarged liver with diffuse coarse spots in liver *** cases had enlarged gallbladder with thickened coarse wall and image of floating plagues,9 cases had slightly enlarged

关键词： Adolescent Adult Aged Animals Child clonorchiasis control Clonorchis sinensis Diet Female Fisheries Health Knowledge, Attitudes, Practice Humans Incidence Male Middle Aged Occupational Diseases

Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World Journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study clonorchiasis

Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and contro

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Infectious Diseases of Poverty 2016年第1期5卷 636-647页

作者： Ze-Li Tang Yan Huang Xin-Bing Yu Department of Parasitology Zhongshan School of MedicineSun Yat-sen University74 Zhongshan 2nd RoadGuangzhou 510080People’s Republic of China Key Laboratory for Tropical Diseases Control Sun Yat-sen UniversityMinistry of EducationGuangzhou 510080People’s Republic of China

clonorchiasis,caused by Clonorchis sinensis(***),is an important food-borne parasitic disease and one of the most common ***,it is estimated that more than 200 million people are at risk of *** infection,and over 15 million are infected *** infection is closely related to cholangiocarcinoma(CCA),fibrosis and other human hepatobiliary diseases;thus,clonorchiasis is a serious public health problem in endemic *** article reviews the current knowledge regarding the epidemiology,disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting *** infection in humans and intermediate hosts and vaccine development against *** data regarding the pathogenesis of clonorchiasis and the genome,transcriptome and secretome of *** are collected,thus providing perspectives for future *** advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.

关键词： clonorchiasis Clonorchis sinensis Diagnosis Pathogenesis Omics Prevention

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The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma

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Infectious Diseases of Poverty 2012年第1期1卷 20-30,19页

作者： Men-Bao Qian Ying-Dan Chen Song Liang Guo-Jing Yang Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiPeople’s Republic of China Department of Environmental and Global Health College of Public Health and Health Professionsand Emerging Pathogens InstituteUniversity of FloridaGainesvilleUSA Jiangsu Institute of Parasitic Diseases WuxiPeople’s Republic of China School of Public Health Chinese University of Hong KongHong KongPeople’s Republic of China

This paper reviews the epidemiological status and characteristics of clonorchiasis at global level and the etiological relationship between Clonorchis sinensis infection and cholangiocarcinoma(CCA).A conservative estimation was made that 15 million people were infected in the world in 2004,of which over 85%distributed in *** epidemiology of clonorchiasis is characterized by rising trend in its prevalence,variability among sexes and age,as well as endemicity in different *** data indicate that *** infection is carcinogenic to human,and it is predicted that nearly 5000 CCA cases attributed to *** infection may occur annually in the world decades later,with its overall odds ratio of *** is becoming one major public health problem in east Asia,and it is worthwhile to carry out further epidemiological studies.

关键词： clonorchiasis Clonorchis sinensis Epidemiology Cholangiocarcinoma Odds ratio

Ultrasonic diagnosis of patients with clonorchiasis and preliminary study of pathogenic mechanism

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 684-687页

作者： Mei Fan Lin Lu Chun Su Mei Xue Ji-Mei Dou Pei Li Han-Qi Feng Yan-Bing Fan Department of Ultrasound the First Affiliated Hospital of Zhengzhou University Department of Radiology the Third Affiliated Hospital of Zhengzhou University The Fifth Affiliated Hospital of Zhengzhou University Henan Experimental Kindergarden Department of Pathphysiology Zhengzhou University The Third Affiliated Hospital of Zhengzhou University Anyang Hospital of Traditional Chinese Medicine

Objective:To discuss the liver function damage mechanism of patients with clonorchiasis by analyzing the ultrasound characteristics,liver function,change of the serum inflammatory factors and cell apoptosis ***:Color Doppler ultrasound technique was adopted to detect the portal vein and blood flow change of patients with clonorchiasis;ELISA was used to determine the level of different serum inflammatory *** levels of serum total bilirubin,serum albumin and glutamic-pyruvic transaminase were detected by automatic biochemical *** blot was used to determine the expression of proteins relevant to ***:Compared with the health control group,the trunk diameter of portal vein and the thickness of spleen,as well as the hepatic artery pulsation index of clonorchiasis patients increased obviously,the mean blood flow velocity of portal vein(Pclonorchiasis.

关键词： clonorchiasis Ultrasonic diagnosis Inflammatory reaction Cell apoptosis

Time to tackle clonorchiasis in China

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Infectious Diseases of Poverty 2013年第1期2卷 23-26,22页

作者： Men-Bao Qian Ying-Dan Chen Fei Yan National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghaiPeople’s Republic of China School of Public Health Fudan UniversityShanghaiPeople’s Republic of China

Recent publication of the global epidemiology of clonorchiasis and its relationship with cholangiocarcinoma in the journal of Infectious Diseases of Poverty has stressed the importance of Clonorchis sinensis *** further demonstrate its threat on public health,especially in China,comparisons between clonorchiasis and hepatitis B are made in terms of epidemiology,clinical symptoms and carcinogenicity,disability,as well as changing ***,major problems and prioritized researches are argued,from basic biology to *** between the majority of infected population and the minority of researches in China urges for more work from Chinese scientists and international cooperation.

关键词： Clonorchis sinensis clonorchiasis Hepatitis B virus Liver cancer Research

Synergistic Action of clonorchiasis,HBV Infection and Alcohol Consumption on Primary Hepatocellular Carcinoma

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Chinese Journal of Clinical Oncology 2009年第2期6卷 104-112页

作者： Shengkui Tan Xiaoqiang Qiu Hongping Yu Xiaoyun Zeng Zengming Xiao Lequn Li Qiuan Zhong Department of Preventative Medicine Guilin Medical ColLege Guilin 541001 Guangxi Zhuang Autonomous Region China Department of Epidemiology School of Public Health Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China Department of Hepatobiliary Surgery The First Hospital of Guangxi Medical UniversityNanning 530021 Guangxi Zhuang Autonomous Region China

OBJECTIVE It has been recognized that HBV infection and alcohol consumption are two important risk factors for primary hepatocellular carcinoma （HCC）. Recently, the role of clonorchiasis as a risk factor for HCC is controversial. We aimed to investigate whether these factors increase the risk of HCC in Guangxi, China. METHODS A hospital-based, case-control study of HCC was conducted from July 2005 to July 2007. We enrolled 500 consecutive patients with HCC as an experimental group and 500 patients without tumor in liver as a control group. The risk factors that the patients were exposed to were assessed. RESULTS Comparing the risks of developing the HCC, we found out the following results. The risk of developing HCC for the patients with clonorchiasis was 5 folds of that for the patients without clonorchiasis （OR = 5.0; 95% CI： 3.1-8.1）, and the risk for the patients with alcohol consumption was 3 folds of that for the patients without drinking alcohol （OR = 3.4; 95% CI： 2.3-4.9）, and similarly, the risk for the patients with HBV infection was 21 times of that for the patients without HBV infection （OR = 20.6; 95% CI： 14.3-29.7）. According to crossover analysis, there was significant interaction among clonorchiasis, HBV infection and alcohol consumption, with synergistic indices greater than 1. The etiologic fractions attributed to these interactions [EF （A × B）] are 0.7465, 0.5789 and 0.5506, respectively. CONCLUSION clonorchiasis, HBV infection and heavy alcohol consumption are independent risk factors for developing HCC in our population in Guangxi, and as they can interact synergistically, the risk of developing HCC is increased. Data from this study may indicate new prevention strategies of developing HCC in high-risk individuals.

关键词： primary hepatocellular carcinoma risk factor clonorchiasis HBV infection alcohol consumption synergistic action.

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Current status and perspectives ofand clonorchiasis: epidemiology, pathogenesis, omics, prevention and control

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贫困所致传染病（英文） 2016年第4期 14-25页

clonorchiasis, caused byClonorchis sinensis (C. sinensis), is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk ofC. sinensis infection, and over 15 million are infected worldwide.C. sinensis infection is closely related to cholangiocarcinoma (CCA), fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detectingC. sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome ofC. sinensis are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.

关键词： clonorchiasis Clonorchis sinensis Diagnosis Pathogenesis Omics Prevention

Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous, straight zone in Southeast Asia

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贫困所致传染病(英文) 2024年第02期13卷 39-51页

作者： Zheng Jin-Xin Zhu Hui-Hui Xia Shang Qian Men-Bao Nguyen Hung Manh Sripa Banchob Sayasone Somphou Khieu Virak Bergquist Robert Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University The University of Edinburgh Shanghai China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasites and Vectors Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases Shanghai China Institute of Ecology and Biological Resources Graduate University of Science and Technology Vietnam Academy of Science and Technology Hoang Quoc Viet Street Hanoi Vietnam WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease) Tropical Disease Research Laboratory Department of Tropical Medicine Faculty of Medicine Khon Kaen University Mittraparb Road Khon Kaen Thailand Lao Tropical and Public Health Institute Ministry of Health Vientiane Lao PDR National Centre for Parasitology Entomology and Malaria Control Ministry of Health Phnom Penh Cambodia Ingerod Brastad Sweden (formerly at the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases) World Health Organization Geneva Switzerland

Background clonorchiasis and opisthorchiasis, caused by the liver flukesClonorchis sinensis andOpisthorchis viverrini respectively, represent significant neglected tropical diseases (NTDs) in Asia. The co-existence of these pathogens in overlapping regions complicates effective disease control strategies. This study aimed to clarify the distribution and interaction of these diseases within Southeast *** We systematically collated occurrence records of human clonorchiasis (n = 1809) and opisthorchiasis (n = 731) across the Southeast Asia countries. Utilizing species distribution models incorporating environmental and climatic data, coupled machine learning algorithms with boosted regression trees, we predicted and distinguished endemic areas for each fluke species. Machine learning techniques, including geospatial analysis, were employed to delineate the boundaries between these *** Our analysis revealed that the endemic range ofC. sinensis andO. viverrini in Southeast Asia primarily spans across part of China, Vietnam, Thailand, Laos, and Cambodia. During the period from 2000 to 2018, we identifiedC. sinensis infections in 84 distinct locations, predominantly in southern China (Guangxi Zhuang Autonomous Region) and northern Vietnam. In a stark contrast,O. viverrini was more widely distributed, with infections documented in 721 locations across Thailand, Laos, Cambodia, and Vietnam. Critical environmental determinants were quantitatively analyzed, revealing annual mean temperatures ranging between 14 and 20 °C in clonorchiasis-endemic areas and 24–30 °C in opisthorchiasis regions (P < 0.05). The machine learning model effectively mapped a distinct demarcation zone, demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1. The study in Vietnam delineates the coexistence and geographical boundaries ofC. sinensis andO. viverrini, revealing distinct endemic zones and a transitional area where both live

关键词： Liver fluke clonorchiasis Opisthorchiasis Clonorchis sinensis Opisthorchis viverrine Southeast Asia Machine learning Ecological study