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A Strategy to Employ clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression

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Natural Products and Bioprospecting 2015年第6期5卷 293-306页

作者： A.Anita Margret T.Nargis Begum S.Parthasarathy S.Suvaithenamudhan Department of Biotechnology and Bioinformatics Bishop Heber CollegeTiruchirappalli 620017India Department of Biotechnology Jamal Mohamed CollegeTiruchirappalli 620020India Department of Bioinformatics School of Life SciencesBharathidasan UniversityTiruchirappalli 620024India

Ayurveda is a renowned traditional medicine practiced in India from ancient times and clitoria ternatea is one such prospective medicinal herb incorporated as an essential constituent in a brain tonic called as medhya rasayan for treating neurological *** work emphasises the significance of the plant as a brain drug there by upholding Indian *** phytochemicals from the root extract were extricated using gas chromatography–mass spectrometry assay and molecular docking against the protein Monoamine oxidase was performed with four potential compounds along with four reference compounds of the *** persuades the prospect of *** as a remedy for neurodegenerative diseases and *** in silico assay enumerates that a major compound(Z)-9,17-octadecadienal obtained from the chromatogram with a elevated retention time of 32.99 furnished a minimum binding affinity energy value of-6.5 kcal/mol against monoamine oxidase(MAO-A).The interactions with the amino acid residues ALA 68,TYR 60 and TYR 69 were analogous to the reference compound kaempferol-3-monoglucoside with a least score of-13.90/-12.95 kcal/mol against the isoforms(MAO)A and *** study fortifies the phytocompounds of *** as MAO-inhibitors and to acquire a pharmaceutical approach in rejuvenating Ayurvedic medicine.

关键词： (Z)-9,17-Octadecadienal Kaempferol-3-monoglucoside Monoamine oxidase clitoria ternatea Molecular docking Ayurvedic medicine

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