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Risk factors of postoperative cerebral hyperperfusion syndrome and its relationship with clinical prognosis in adult patients with moyamoya disease

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Chinese Neurosurgical Journal 2023年第3期9卷 190-198页

作者： Zhiyong Shi Lingyun Wu Yi Wang Huasheng Zhang Yongbo Yang Chunhua Hang Department of Neurosurgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNo.321 Zhongshan RoadNanjingJiangsu Province MN 210008People’s Republic of China

Background To investigate the incidence,risk factors,and clinical prognosis of cerebral hyperperfusion syndrome(CHS)after superficial temporal artery-middle cerebral artery anastomosis combined with encephalo-duro-arterio-synangiosis(STA-MCA/EDAS)in adult patients with moyamoya disease(MMD).Methods The clinical data of 160 adult patients with MMD treated by STA-MCA/EDAS from January 2016 to January 2017 were retrospectively *** to CHS diagnosis,MMD patients were divided into CHS and non-CHS *** and multivariate analysis of risk factors and Kaplan-Meier curve of stroke-free survival for CHS were *** A total of 12 patients(7.5%)developed postoperative CHS,of which 4 patients(2.5%)presented with cerebral *** and multivariate analysis showed moyamoya vessel on the surgical hemisphere(OR=3.04,95%CI=1.02-9.03,P=0.046)and left operated hemisphere(OR=5.16,95%CI=1.09-21.34,P=0.041)were independent risk factors for *** other variables,such as age,gender,presentation,hypertension,diabetes,smoking,mean mRS score on admission,modified Suzuki stage and pre-infarction stage on surgical hemisphere,and bypass patency,had no association with postoperative CHS(P>0.05).At final follow-up with average 38 months,there were 18 out of 133 patients(13.5%,4.91%per person year)presented with newly developed *** was no significant difference between newly developed complications,mean mRS scores,and Kaplan-Meier curve of stroke-free survival in patients with and without CHS(P>0.05).Conclusion The concentration of moyamoya vessels and left operated hemisphere was independent risk factors for CHS,which could not affect the clinical prognosis if treated timely and *** current study offers a new perspective of moyamoya vessels and supporting data for choosing MMD candidates on cerebral revascularization.

关键词： Moyamoya disease Combined cerebral revascularization Cerebral hyperperfusion syndrome Risk factors clinical prognosis

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Investigation of the role of TIM-3 in non-Hodgkin's lymphoma

Investigation of the role of TIM-3 in non-Hodgkin's lymphoma

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浙江省免疫学会第十三次学术大会

作者： Wenwen Wang Jianlin Chen Qunyi Guo Department of Hematology Taizhou Central Hospital Department of Hematology Taizhou Hospital of Zhejiang

Background:We aim to study the impact of T cell immunoglobulin and mucin-domain containing-3(TIM-3) on prognosis and treatment efficacy in non-Hodgkin's lymphoma(NHL) ***:The purpose of this study is to seek new efficacy evaluation indicators and prognostic biomarkers for NHL patients,and even new treatment *** and methods:Immunohistochemistry was applied to detect the expression of TIM-3 in 36 NHL patients and 30 healthy *** relationships between TIM-3 expression level and collected clinical characteristics,laboratory indices,and prognosis were ***:The NHL group expressed a higher TIM-3 than the control group(Pclinical staging and risk grouping but negatively correlated with the complete remission(CR) rate(Pclinical stage and increased ***:TIM-3 positive NHL patients have low CR rates,which can be a predictor of poor clinical treatment *** study doesn't support that TIM-3 level correlates with NHL prognosis.

关键词： TIM-3 non-Hodgkin's lymphoma clinical features laboratory indicators clinical prognosis

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