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Comparison between visual clinical examination and the replica method for assessments of sealant retention over a 2-year period

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International Journal of Oral Science 2014年第2期6卷 111-115页

作者： Xuan Hu Xi Chen Lu Ye Ming-Wen Fan Marie-Charlotte Huysmans Jo E Frencken State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Department of Preventive Dentistry School and Hospital of Stomatology Wuhan University Private Practitioner Department of Preventive and Restorative Dentistry College of Dental Sciences Radboud University Nijmegen Medical Centre Nijmegen The Netherlands Department of Global Oral Health College of Dental Sciences Radboud University Nijmegen Medical Centre Nijmegen The Netherlands

To compare the levels of agreement and the survival rates of sealant retention for different sealing materials over a 2-year period assessed using the visual clinical examination and replica methods, sealant retention data were obtained by visual clinical examination and from replicas of the same sealed tooth at baseline and at 0.5-, 1- and 2-year evaluation points in 407 children and were compared for agreement using kappa coefficients. Survival curves of retained sealants on occlusal surfaces were created using modified categorisation （fully retained sealants and those having all pits and fissures partly covered with the sealant material versus completely lost sealants that included pit and fissure systems that had /〉 1 pit re-exposed） according to the Kaplan-Meier method. The kappa coefficient for the agreement between both assessment methods over the three evaluation time points combined was 0.38 （95% confidence interval （CI）： 0.35-0.41）. More sealant retention was observed from replicas than through visual clinical examination. Cumulative survival curves at the three evaluation times were not statistically significantly higher when assessed from replicas （P=0.47）. Using the replica method, more retained sealant material was observed than through visual clinical examination during the 2-year period. This finding did not result in a difference in the survival rates of sealants assessed by the two assessment methods. When replicas cast in die stone are used for assessing sealant retention, the level of reliability of the data is higher than that of data obtained through the commonly used visual clinical examination, particularly if such assessments are conducted over time.

关键词： clinical examination replica method sealant retention sealant

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Evaluation of Accuracy of clinical examination and MRI on Diagnosing Anterior Cruciate Ligament and Meniscal Tears in Comparison to Diagnostic Arthroscopy among Patients Attending at Muhimbili Orthopedic Institute

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Open Journal of Orthopedics 2021年第12期11卷 353-370页

作者： Hellen Machagge Felix Mrita Mohamed Muhamedhussen Billy Haonga Cuthbert N. Mcharo Muhimbili Orthopedic Institute Dar-es-Salaam Tanzania Muhimbili University of Health and Allied Sciences Dar-es-Salaam Tanzania Ebrahim Haji Charitable Health Centre Dar-es-Salaam Tanzania

Routine use of Magnetic Resonance Imaging (MRI) as screening test after clinical diagnosis for meniscal and/or anterior cruciate ligament (ACL) has a detrimental effect on patients in limited resourced countries. This study was done to compare accuracy of clinical examination and that of (MRI) on diagnosing meniscal and or (ACL) tears. Methodology: A cross-sectional-descriptive study was done on 57 knees of patients. Clinical examination, MRI and then diagnostic arthroscopy, as the gold standard, were done to all the cases. Results were recorded;the accuracies of MRI and clinical examination were evaluated and their results were compared. Results: Median age of patients was 40 years. Clinical examination had sensitivity of 93.62% and specificity of 40% for diagnosing meniscal tears;and sensitivity of 100%;and specificity of 97.67% for diagnosing ACL tear. MRI had sensitivity of 85.11%, and specificity of 40% for meniscal tear diagnosis and 71% and 100% respectively for ACL tear diagnosis. Diagnostic accuracy was 84.21% for meniscal and 98.24% for ACL tears by clinical examination and by MRI was<

关键词： MRI clinical examination Diagnostic Accuracy ACL Meniscal

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clinical implications of reconsideration of enthesitis/enthesopathy/enthesial erosion,as tendon attachmentlocalized avulsions and stress fracture equivalents

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World Journal of Orthopedics 2024年第10期15卷 902-907页

作者： Bruce M Rothschild Department of Medicine Indiana University Ball Memorial HospitalMuncieIN 47303United States

Recognizing the mechanical origin of enthesitis/enthesopathy and the avulsion-nature of what had previously been considered erosions,it seems inappropriate to attribute it to stresses related to a person’s normal ***,sudden or unconditioned repetitive stresses appears the more likely *** of enthesial reaction have lacked standardization as to findings present among individuals who appear to be *** evaluation by palpation and mani-pulation may be as effective as application of radiologic *** of the mechanical nature of the disease,including individuals with inflammatory arthritis suggests prescription of mechanical solutions that reduce stresses across the involved enthesis.

关键词： Enthesitis Epicondylitis Erosion Avulsion clinical examination

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The Chinese Expert Consensus on Evaluation of Coma after Cardiopulmonary Resuscitation

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Chinese Medical Journal 2016年第17期129卷 2123-2127页

作者： Su, Ying-Ying Huang, Xu-Sheng Pan, Su-Yue Peng, Bin Jiang, Wen Capital Med Univ Xuanwu Hosp Dept Neurointens Care Unit Beijing 100053 Peoples R China Chinese Peoples Liberat Army Gen Hosp Dept Neurol Beijing 100853 Peoples R China Southern Med Univ Nanfang Hosp Dept Neurol Guangzhou Guangdong Peoples R China Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Neurol Beijing Peoples R China Peking Union Med Coll Beijing Peoples R China Fourth Mil Med Univ Xijing Hosp Dept Neurol Xian Peoples R China

INTRODUCTIONThe prognosis of patients who suffer from coma after cardiopulmonary resuscitation （CPR） may be poor （defined as cerebral performance categories scores from 3 to 5） Thus, an accurate prediction of their neurological outcomes is an essential component of post-cardiac arrest evaluation, especially for decisions to limit or withdraw life-sustaining care. Since the 1960s, a series of domestic and foreign studies began to focus on the evaluation of coma patients after CPR, and considerable progress has been achieved in this field.

关键词： Cardiopulmonary Resuscitation Coma Consensus Electrophysiological examination Neuroimaging Neurological Biomarkers clinical examination

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Genetic and environmental factors associated with the diversity and biases of immune system

Genetic and environmental factors associated with the divers...

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第十三届全国免疫学学术大会

作者： Ziyun Wan Wei Zhang Xiao Liu BGI-Shenzhen China National GeneBank BGI-Shenzhen

The extremely large diversity of T-cell receptor(TCR) repertoire make up of individual immune system, acting against the external Pathogenic infection and enabling individual to keep healthy. The process of germline VDJ rearrangement, that comprise of VDJ gene recombination and random nucleotides deleted or inserted during the junction of V-D and D-J regions, contribute the huge TCR diversity and is regulated by both genetic factors and environment stimulation. The genetic influence are involved during the period of negative and positive selection of T cells in thymus and external antigen presentation. Additionally, auto or exogenous antigen stimulation causes some TCRs expansion. To explore how genetic factors and environment stimulation regulate the diversity of TCR repertoire, we collected more than 1000 volunteers and all were amplified TCR β repertoire and sequenced using high throughput sequencer. Simultaneously, multi-dimensional data were generated, including whole genome sequences(WGS), clinical tests, metabolomes, microbiomes, tumor screen, psychological test and so on. Using all of these data, we utilized bioinformatic method to identify genetic variations from WGS data associated with TCR β V genes and overall clone diversity, and found many associated variations in major histocompatibility complex(MHC) region. According to comparison of TCR repertoire and internal/external environmental data, we can find which factors are strong correlated with the diversity of TCRs. Our results clearly demonstrate the genetic environmental factors regulate the diversity of TCR repertoires, which provide clues for avoiding decreasing the capacity of immune system, and prevention and therapy of immune related disease.

关键词： T-cell receptor immune system whole genome sequencing clinical examination HLA

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