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Effect of Acupuncture on Outcomes of in vitro Fertilisation:A Scoping Review

Chinese Journal of Integrative Medicine 2022年第5期28卷 472-480页

作者： XIU Wen-cui GANG Wei-juan JIAO Rui-min SHI Lan-jun YANG Ji-wei JING Xiang-hong SHI Xiao-shuang Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing(100700)China

Objectives:To identify,examine and summarize the available evidence on the effectiveness and safety of acupuncture for in vitro fertilisation(IVF)outcomes.Methods:Eight electronic databases,including Pub Med,EMBASE,Cochrane Database of Systematic Review,Cochrane Central Register of Controlled Trials,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database and VIP Database,were searched,supplemented by manual searches.Two researchers independently conducted the literature screening,data extraction,and methodological quality assessments.A narrative description was provided to show the general information and specific characteristics of the included studies.A bubble plot was used to visually display the overall effects of acupuncture on IVF outcomes.Results:Eighty-two studies were identified,including 64 primary studies and 18 systematic reviews.Transcutaneous electrical acupoint stimulation,electric acupuncture and manual acupuncture were applied in most studies and compared with no acupuncture,sham acupuncture and placebo acupuncture control groups.Sixty-three(98.4%)primary studies reported clinical pregnancy rate,and positive effects of acupuncture were found in 34 studies(54.0%).Live birth rate was reported in only 18(28.1%)primary studies,of which 10(55.6%)showed positive results.In addition,only 8 and 2 systematic reviews showed that acupuncture could increase clinical pregnancy events and live birth events,respectively.However,none of these reviews was of high methodological quality.Conclusions:Available evidence suggests that acupuncture therapy could improve clinical pregnancy rates.However,whether acupuncture could increase live birth events was difficult to determine based on the few studies that have reported this outcome indicator.Furthermore,the methodological quality of most systematic reviews was assessed as critically low or low.Studies with a rigorous design and standardized implementation should be performed to refine the available evidence.

关键词： acupuncture in vitro fertilisation clinical pregnancy rate live birth rate scoping review

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pregnancy Outcomes for Day 5 Versus Day 6 Single Frozen-thawed Blastocyst Transfer with Different Qualities of Embryos: A Large Matched-cohort Study

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Current Medical Science 2023年第2期43卷 297-303页

作者： Qiong YU Hui HE Xin-ling REN Shi-fu HU Lei JIN Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to determine whether the day of blastocyst expansion affects pregnancy outcomes in frozen-thawed blastocyst transfer(FBT)cycles.Methods A retrospective match-cohort study was conducted.Patients who underwent blastocyst transfer in frozen-thawed cycles at day 5 or 6 were matched for potential confounding factors.A total of 2207 matched pairs of FBT cycles were included from January 2016 to December 2019 in our Reproductive Medicine Center.Results The clinical pregnancy rate(CPR)and live birth rate(LBR)were significantly increased in day 5 blastocyst transfers when compared to day 6 blastocyst transfers,in terms of the same embryo quality.For FBT cycles with good-quality embryo,the CPR at day 5 and 6 was 61.30%and 57.56%,respectively(P=0.045),and the LBR was 44.79%and 36.16%,respectively(P<0.001).For FBT cycles with poor-quality embryo,the CPR at day 5 and 6 was 48.61%and 40.89%,respectively(P=0.006),and the LBR was 31.71%and 25.74%,respectively(P=0.019).The CPR for FBT cycles with good-quality embryo was statistically higher at day 6 than that at day 5 with poor-quality embryo transferred(57.56%vs.48.61%,P=0.001).Maternal age,anti-Müllerian hormone(AMH),endometrial thickness,embryo quality,and the day of blastocyst expansion were independently correlated with the CPR and LBR.The FBT cycles at day 5 had significantly higher CPR(adjusted odds ratio[OR]=1.246,95%confidence intervals[CI]:1.097–1.415,P=0.001)and LBR(adjusted OR=1.435,95%CI:1.258–1.637,P<0.001)than those at day 6.Conclusion The embryo quality is the primary indicator for FBT cycles.Day 5 blastocysts should be preferred when the quality of embryo at day 5 is the same as that at day 6.

关键词： frozen-thawed blastocyst transfer day 5 versus day 6 embryo quality clinical pregnancy rate live birth rate

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pregnancy outcomes of four different cycle protocols for frozen embryo transfer: a large retrospective cohort study

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Reproductive and Developmental Medicine 2023年第3期7卷 135-141页

作者： Yue Qian Qi Wan Xiao-Qing Bu Tian Li Xiao-Jun Tang Yan Jia Qian Feng Xing-Yu Lv Xiang-Qian Meng Yin Yang Yu-Bin Ding Li-Hong Geng Min Xia Zhao-Hui Zhong Department of Epidemiology School of Public Health and ManagementResearch Center for Medicine and Social DevelopmentInnovation Center for Social Risk Governance in HealthChongqing Medical UniversityChongqing 400016China Chengdu Xi'nan Gynecological Hospital Chengdu 610011China Department of Gynecology and Obstetrics West China Second HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Reproductive Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of China School of Public Health and ManagementChongqing Medical UniversityChongqing 400016China Department of Gynecology Chongqing Hospital of Traditional Chinese MedicineChongqing 4uuuzlChina.

Objective:To evaluate the pregnancy outcomes of the four endometrial preparation protocols for people undergoing frozen-thawed embryo transfer(FET),including natural cycle(NC),hormone replacement therapy cycle(HRT),gonadotropin-releasing hormone agonist artificial cycle(GAC),and ovarian stimulation cycle(OC).Methods:This retrospective cohort study enrolled 10,333 cycles of frozen embryo transfer performed at Xinan Gynecological Hospital in Sichuan,China,from January 2018 to December 2018.The patient's baseline characteristics and pregnancy outcomes were extracted from the medical record system.pregnancy outcomes were compared among the four groups and multiple logistic regression models were used to adjust for the confounding factors.Results:After adjusting for covariates,multiple logistic regression analysis showed no statistical significance in pregnancy outcomes in the HRT group,GAC group,and OC group compared to the NC group in the entire population.The adjusted odds ratio of live birth was 0.976(95%)confidence interval[Cl](0.837-1.138)for the HRT group,0.959(95%confidence interval 0.797-1.152)for the GAC group,and 0.909(95%confidence interval 0.763-1.083)for the OC group.Conclusions:The natural protocol had comparable pregnancy outcomes compared to the other three endometrial preparation protocols in the overall FET population.More high-quality prospective randomized controlled trials are required to assess the efficacy of the four protocols and explore the optimal one.

关键词： clinical pregnancy rate Endometrial preparation protocols Frozen-thawed embryo transfer Live birth rate Natural cycle

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Intrauterine Insemination Treatment Strategy for Women over 35 Years Old： Based on a Large Sample Multi-center Retrospective Analysis

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Chinese Medical Journal 2016年第23期129卷 2873-2875页

作者： Shuo Yang Hong-Ying Peng Ying Li Li-Ying Zhou Li Yuan Yan-Min Ma Hui-Chun Wang Rong Li Ping Liu Jie Qiao Reproductive Medical Center Peking University Third Hospital Beijing 100191 China Reproductive Medical Center Haidian Maternal and Child Health Hospital Beijing 100080 China Reproductive Medical Center Beijing Obstetrics and Gynecology Hospital Beijing 100006 China Reproductive Medical Center Tianjin Fifth Central Hospital Tianjin 300450 China

As we all known, maternal age and ovarian reserve are two of the most important prognosis i-hctors for fertility, in 1980, the study of Menken et al. showed the female fertility declined after 32 years old, especially... 详细信息

关键词： clinical pregnancy rate Intrauterine Insemination Live Birth rate Maternal Age

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clinical Analysis on IVF-ET Treatment of 9 Cases of Post-cesarean Section Uterine Diverticulum

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Journal of Reproduction and Contraception 2011年第3期22卷 183-190页

作者： Qiong-fang WU Ling NIE Yin ZHANG Reproduction Center Jiangxi Maternal and Child Health Hospital Nanchang 330006 China Medical College of Nanchang University Nanchang 330006 China

Objective To evaluate the influence of uterine diverticulum patients who have a history of cesarean section on IVF-ET process and pregnancy outcome. Methods Nine patients with uterine diverticulum after cesarean were retrospectively analyzed, who have received IVF-ET treatment. clinical pregnancy rate and embryo implantation rate were measured. Results There were 9 infertility patients in all, 7 cases with tubal factor, 2 with unexplained factor; 3 cases were associated with prolonged menstruation period, including 1 patient was misdiagnosed as dysfunctioned uterine bleeding. There were a total of 16 transplantation cycles, including14 fresh cycles and 2 thawing cycles. Each cycle had at least one high-quality embryo available for transfer. Five cases were difficult to transfer. Two were clinical pregnancie, the implantation rate was 5.13% （2/39）. Conclusion In this study, 14 fresh cycles all had high-quality embryo transfer, uterine diverticulum had no effect on the development of ovums and the formation of high- quality embryos. But forming uterine diverticulum after cesarean section may lead to secondary infertility or patients with prolonged menstruation period, it also may lead it difficult to transfer during the treatment of IVF-ET and affect embryo implantation. So the patients with a history of cesarean section shall receive ultrasonic examination or hysteroscopy routinely before IVF treatment. If necessary surgical treatment is required.

关键词： cesarean section history uterine diverticulum in vitro fertilization-embryo transfer （IVF-ET） clinical pregnancy rate embryo implantation rate

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pregnancy rate after Embryo Transfer on Day 5 and Day 6 in IVF. A Systematic Review and Meta-Analysis

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Advances in Reproductive Sciences 2021年第1期9卷 97-105页

作者： Hassan S. Abduljabbar H. Hashim M. Gehad Heba E. Hashish A. Algaradi Department Obstetrics and Gynecology Medical College King Abdulaziz University Jeddah Makkah Saudi Arabia Jeddah Fertility Center at the Department of Obstetrics and Gynaecology Dr. Erfan Bagedo General Hospital Saudi ArabiaJeddah KSA

Study Question: The question: is there any difference in pregnancy rate between embryo transfer day 5 and day 6 in IVF? What Is Known Already? Blastocyst transfer is increasingly popular in assisted reproductive technology (ART) centers today. Very few articles concentrate on comparing Day 5 and Day 6 embryo transfer with conflict results. Objective, Study Design: Systematic review and meta-analysis of published controlled studies. Searches conducted from 2001-2020 on PubMed. Medline, EMBASE, and ISI Web of Science Electronic database is used to collect data, using the following search terms: blastocyst, Day 5, Day 6, embryo transfer (E.T.) and pregnancy rate. Materials, Setting, Methods: A total of 6 full-text articles preselected from 211 references, based on title and abstract. Two independent reviewers performed data selection and extraction according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA). This systematic review was conducted according to (PICO) standard. Random-effect meta-analysis performed on all data (overall analysis). Results and the Role of Chance: Data from 6 relevant articles were extracted and integrated into the meta-analysis that reported clinical pregnancy rate (CPR) as an outcome in 5640 cycles, 2274 cycle had embryo transfer at day 6 and the control was 3366 cycle had embryo transfer day 5 showed a significantly higher clinical pregnancy rate following Day 5 embryo transfer compared with Day 6 embryo transfer with odd ratio and 95% confidence limit 0.73 (0.66 - 0.82) p value Limitations, Reasons for Caution: The validity of meta-analysis results depends mainly on the quality and the number of published studies available. Indeed, this meta-analysis included no randomized controlled trial (RCT). Wider Implications of the Findings: In regards to the results of this

关键词： Day 5 Day 6 IVF Blastocyst clinical pregnancy rate

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The Relationship between Serum Progesterone Concetrations、Progesterone/Estradiol Ratio on the day of Human Chorionic Gonadotropin Adiministration and clinical pregnancy in IVF-ET Cycles

The Relationship between Serum Progesterone Concetrations、P...

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2012浙江省计划生育与生殖医学学术年会

Objective (i) To evaluate the relationship between serum progesterone level on the day of human chorionic gonadotropin(HCG) administration and clinical pregnancy during in vitro fertilization and embryo transfer(IVFET) cycles with long protocol. (ii) To evaluate the relationship between progesterone/estradiol(P/E2) ratio on the day of human chorionic gonadotropin administration and clinical pregnancy in IVF-ET cycles with long protocol. Methods (i) From January 2010 to December 2011,all the complete IVF-ET circles were analyzed retrospectively on Reproductive Health Center in Second Affiliated Hospital of Wenzhou Medical Colleage. (ii) Accroding the serum progesterone level on the day of HCG administration The cutoff point were set at 1.0,1.5 and 2.0ng/ml,respectively.If the level of progesterone was less than the thresthold,those patients were in lower progesterone group,on the contrary,more than the threshold value,those patients were in higher progesterone group.General clinical data,laboratory results and the clinical pregnancy rate between the lower and higher group at different cutoff point were analyzed. (iii) Accroding the P/E2 ratio on the day of HCG administration The cutoff point were set at 0.5,1.0 and 1.5, respectively.If the ratio of P/E2 was less than the cutoff value,those patients were in lower ratio group,on the contrary,more than the threshold value,those patients were in higher ratio group.General clinical data,laboratory results and the clinical pregnancy rate between the lower and higher ratio group at different threshold were analyzed. Results (i) From January 2010 to December 2011,two thousand two hundred and sixteen circles were completed in our center totally,in which 370 IVF-ET circles met the inclusion criteria. (ii) Data collected from our hospital group by the serum progesterone level on the day of HCG administration No statistically significant difference were found with respect to clinical pregnant rate between lower and higher serum progesterone groups at any cutoff points(P>0.05)

关键词： IVF-ET progesterone progesterone/estradiol clinical pregnancy rate

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