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Wells’syndrome possibly caused by hematologic malignancy,influenza vaccination or ibrutinib:A case report

World Journal of clinical cases 2022年第30期10卷 10997-11003页

作者： Mihela Šajn Boštjan Luzar Samo Zver Department of Hematology University Medical Centre LjubljanaLjubljana 1000Slovenia Institute of Pathology Medical Faculty LjubljanaLjubljana 1000Slovenia Medical Faculty University of LjubljanaLjubljana 1000Slovenia

BACKGROUND Wells’ syndrome(eosinophilic cellulitis) is an uncommon eosinophilic dermatosis of uncertain pathogenesis,characterized by clinical polymorphism and suggestive but nonspecific histopathologic *** course is recurrent,and response to therapy is *** a case in which the patient has a number of potential triggers for the manifestation of Wells’ syndrome skin rash,the treating physician must decide or must make an assumption in order to establish the most likely clinical *** is important for the patient’s future treatment *** SUMMARY We describe the clinical case of a 46-year-old female with chronic lymphocytic leukemia who had already received treatment for several months with *** was diagnosed with Wells’ syndrome 10 d after an influenza vaccination containing *** on the literature,the patient was treated with a course of oral *** of clinical symptoms and rash were observed in response to the *** was not *** The etiology of Wells’ syndrome remains ***,it resembles bacterial *** of response to antibiotic treatment should lead the physician to consider a diagnosis of Wells’ *** the underlying condition is important and may lead to resolution of the ***,the most common and effective treatment to limit the course of the disease are systemic steroids.

关键词： Wells’syndrome Chronic lymphocytic leukemia Allogenic hematopoietic stem cell transplantation Ibrutinib Thimerosal-containing influenza vaccine clinical case case report

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Multiple Cranial Nerve Palsies in Otolaryngology Consultation: An Atypical clinical Presentation Revealing Myasthenia Gravis

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第6期11卷 306-316页

作者： Adèle-Rose Ngo Nyeki Paul Cedric Mbonda Léonel Atanga Yannick Mossus Roger Meva’a Victor Sini Mambo Olive Ngaba David Mindja Francois Djomou Callixte Kuate Richard Njock Alexis Ndjolo Department of Ophthalmology-ENT-Stomatology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Central Hospital of Yaoundé Yaoundé Cameroon Department of Neurology General Hospital of Yaoundé Yaoundé Cameroon Department of Neurology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Introduction: Myasthenia gravis is a chronic autoimmune neuromuscular disease, presents with weakness and fatigability of striated skeletal muscles. It is a rare disease in Cameroon. We report an uncommon case of myasthenia gravis in a patient with feeding difficulties, notion of oronasal reflux and swallowing disorders as first complaints. Observation: We report the case of a 29-year-old woman consulted at our department of Otolaryngology and Cervico-Facial Surgery for dysphagia and swallowing disorders. She also presented with facial diplegia, oculomotor paralysis, nasal voice, and dysarthria which has been evolving for several years now. The clinical examination revealed multiple cranial nerve palsies. The complementary workup showed a decrement of more than 50% in the electroneuromyography and the presence of anti-acetylcholine receptor autoantibodies in the blood workup. A diagnosis of myasthenia confirms clinical presumption. We initially observed a worsening of neuromuscular disorders despite the pyridostigmine treatment and subsequently a clear improvement of the clinical features concerning swallowing and speech disorders, oculomotricity and facial diplegia under a treatment combining prednisone and azathioprine. Conclusion: Myasthenia gravis is a rare and potentially fatal autoimmune neuromuscular disease. We thus highlight the atypical clinical presentation and therapeutic itinerary of our patient and the importance to think about this clinical diagnosis in front of any multiple cranial nerve paralysis in otolaryngology consultation.

关键词： clinical case Dysphagia Swallowing Disorders Facial Diplegia Nasal Voice Myasthenia Autoimmune Paralysis Cranial Nerves

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Promotion of peripheral nerve regeneration and prevention of neuroma formation by PRGD/PDLLA/b-TCP conduit:report of two cases

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Regenerative Biomaterials 2015年第2期2卷 119-124页

作者： Yixia Yin Binbin Li Qiongjiao Yan Honglian Dai Xinyu Wang Jifeng Huang Shipu Li State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Department of Orthopedic Surgery Wuhan General Hospital of Guangzhou Military CommandWuhan430070China

In the field of nerve repair,one major challenge is the formation of ***,reports on both the promotion of nerve regeneration and prevention of traumatic neuroma in the clinical settings are rare in the field of nerve *** of the reasons could be the insufficiency in the follow-up *** have conducted 33 cases of nerve repair using PRGD/PDLLA/b-TCP conduit without any sign of adverse reaction,especially no neuroma *** them,we have selected two cases as representatives to report in this *** first case was a patient with an upper limb nerve wound was bridged by PRGD/PDLLA/b-TCP conduit and a plate fixation was *** nearly 3-years’follow-up,the examination results demonstrated that nerve regeneration effect was very *** the reoperation was performed to remove the steel plate we observed a uniform structure of the regenerated nerve without the formation of neuroma,and to our delight,the implanted conduit was completely degraded 23 months after the *** second case had an obsolete nerve injury with neuroma *** removal of the neuroma,the nerve was bridged by PRGD/PDLLA/b-TCP ***-up examinations showed that the structure and functional recovery were improved gradually in the 10-month follow-up;no end-enlargement and any other abnormal reaction associated with the characteristic of neuroma were *** on our 33-case studies,we have concluded that PRGD/PDLLA/b-TCP nerve conduit could both promote nerve regeneration and prevent neuroma formation;therefore,it is a good alternative for peripheral nerve repair.

关键词： clinical case peripheral nerve regeneration neuroma formation PRGD/PDLLA/b-TCP conduit

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