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Retinal tissue hypoperfusion in patients with clinical alzheimer’s disease

Eye and Vision 2018年第1期5卷 196-203页

作者： Giovana Rosa Gameiro Hong Jiang Yi Liu Yuqing Deng Xiaoyan sun Bernardo Nascentes Bernard Baumel Tatjana Rundek Jianhua Wang Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA Evelyn F.McKnight Brain Institute Department of NeurologyUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Ophthalmology Third Affiliated Hospital of Nanjing University of Chinese MedicineNanjingChina state Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdongChina school of Nursing and Health studies University of MiamiMiamiFLUSA

Background:It remains unknow whether retinal tissue perfusion occurs in patients with alzheimer’s *** goal was to determine retinal tissue perfusion in patients with clinical alzheimer’s disease(CAD).Methods:Twenty-four CAD patients and 19 cognitively normal(CN)age-matched controls were recruited.A retinal function imager(RFI,Optical Imaging Ltd.,Rehovot,Israel)was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the *** flow volumes of arterioles(entering the macular region)and venules(exiting the macular region)of the supplied area were *** blood flow was calculated as the average of arteriolar and venular flow *** ultra-high-resolution optical coherence tomography(UHR–OCT)was used to calculate macular tissue *** segmentation software(Orion,Voxeleron LLC,Pleasanton,CA)was used to segment six intra-retinal layers in the 2.5 mm(diameter)area centered on the *** inner retina(containing vessel network),including retinal nerve fiber layer(RNFL),ganglion cell-inner plexiform layer(GCIPL),inner nuclear layer(INL)and outer plexiform layer(OPL),was segmented and tissue volume was *** was calculated as the flow divided by the tissue ***:The tissue perfusion in CAD patients was 2.58±0.79 nl/s/mm^(3)(mean±standard deviation)and was significantly lower than in CN subjects(3.62±0.44 nl/s/mm^(3),Pse of 29%.The flow volume was 2.82±0.92 nl/s in CAD patients,which was 31%lower than in CN subjects(4.09±0.46 nl/s,Pssue volume was 0.47±0.04 mm^(3) in CAD patients and 6%lower than CN subjects(0.50±0.05 mm^(3),Psignificant alterations were found in the intra-retinal layers between CAD and CN ***:This study is the first to show decreased retinal tissue perfusion that may be indicative of diminished tissue metabolic activity in patients with clinical alzheimer’s disease.

关键词： clinical alzheimer’s disease Retinal tissue perfusion Blood flow Retinal tissue volume Hypoperfusion Retinal function imager Optical coherence tomography

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