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Primary clear cell carcinoma in the liver: CT and MRI findings

World Journal of Gastroenterology 2011年第7期17卷 946-952页

作者： Qing-Yu Liu Hai-Gang Li Ming Gao Xiao-Feng Lin Yong Li Jian-Yu Chen Department of Radiology The Second Affiliated Hospitalof Sun Yat-sen University Guangzhou 510120 Guangdong Prov-ince China Department of Pathology The Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120Guangdong Province China

AIM: To retrospectively analyze the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of primary clear cell carcinoma of the liver (PCCCL) and compare the imaging appearances of PCCCL and common type hepatocellular carcinoma (CHCC) to determine whether any differences exist between the two groups. METHODS: Twenty cases with pathologically proven PCCCL and 127 cases with CHCC in the Second Affiliated Hospital of Sun Yat-sen University were included in this study. CT or MRI images from these patients were retrospectively analyzed. The following imaging findings were reviewed: the presence of liver cirrhosis, tumor size, the enhancement pattern on dynamic contrast scanning, the presence of pseudo capsules, tumor rupture, portal vein thrombosis and lymph node metastasis. RESULTS: Both PCCCL and CHCC were prone to occur in patients with liver cirrhosis, the association rate of liver cirrhosis was 80.0% and 78.7%, respectively (P > 0.05). The mean sizes of PCCCL and CHCC tumors were (7.28 ± 4.25) cm and (6.96 ± 3.98) cm, respectively. Small HCCs were found in 25.0% (5/20) of PCCCL and 19.7% (25/127) of CHCC cases. No significant differences in mean size and ratio of small HCCs were found between the two groups (P = 0.658 and 0.803, respectively). Compared with CHCC patients, PCCCL patients were more prone to form pseudo capsules (49.6% vs 75.0%, P = 0.034). Tumor rupture, typical HCC enhancement patterns and portal vein tumor thrombosis were detected in 15.0% (3/20), 72.2% (13/18) and 20.0% (4/20) of patients with PCCCL and 3.1% (4/127), 83.6% (97/116) and 17.3% (22/127) of patients with CHCC, respectively. There were no significant differences between the two groups (all P > 0.05). No patients with PCCCL and 2.4% (3/127) of patients with CHCC showed signs of lymph node metastasis (P > 0.05). CONCLUSION: The imaging characteristics of PCCCL are similar to those of CHCC and could be useful for differentiating these from other liver tumors (such as h

关键词： clear cell carcinoma Hepatocellular carcinoma Pathology Magnetic resonance imaging Computed Tomography X-ray

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Therapy and prognostic features of primary clear cell carcinoma of the liver

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World Journal of Gastroenterology 2010年第6期16卷 764-769页

作者： Ji, Sheng-Pu Li, Qiang Dong, Hui Tianjin Med Univ Canc Hosp Dept Hepatobiliary Surg Tianjin 300060 Peoples R China

AIM:To clarify the therapeutic strategies and prognosis factors of primary clear cell carcinoma of the liver(PCCCL) . METHODS:The clinical pathological data of 64 patients with PCCCL treated with hepatectomy in our hospital from January 2000 to January 2006 were analyzed *** patients were divided into two groups to make treatment analysis:curative resection only(n=40) ;and curative resection and postoperative chemotherapy with calcium folinate and tegafur(n= 24) .Meanwhile,the PCCCL patients were subdivided into two subgroups on the basis of the proportion of clear cells in the tumor for pathological *** were 36 cases in subgroup A for which the proportion of clear cells was more than 70%,and 28 cases in subgroup B for which the proportion was less or equal to 70%,comparing analysis of median survival time of the counterpart *** and multivariate analyses were performed to examine factors that affect-ed clinical prognosis,recurrence and metastasis. RESULTS:Median survival period of the curative surgery group was 38 mo,while the counterpart was 41 *** survival period for group A was 41 mo,while group B was 19 *** Kaplan-Meier method showed that capsule formation,preoperative liver function,hepatitis C virus infection,large vascular invasion and multiple tumor occurrences were related to disease-free *** regression analysis showed that the clear cell ratio,capsule formation,preoperative liver function and large vascular invasion were independent risk factors for overall survival. CONCLUSION:Postoperative chemotherapy has no obvious effect on survival of patients with PCCCL. clear cell ratio,capsule formation,preoperative liver function,and vascular invasion were independent risk factors for prognosis.

关键词： clear cell carcinoma Hepatectomy Prognosis Treatment Risk factor

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clear cell carcinoma of the Uterine Cervix Arising from an Interstitial Cyst Complicated with Endometriosis: A Case Report

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Open Journal of Obstetrics and Gynecology 2021年第3期11卷 288-295页

作者： Kana Akagi Takako Tobiume Ayaka Kawamichi Yuichiro Koshida Yusuke Fujikami Eri Ogura Kenji Ban Hisanori Matsumoto Atsuhiko Okagaki Keiji Tatsumi Department of Obstetrics and Gynecology National Hospital Organization Osaka National Hospital Osaka Japan

clear cell carcinoma (CCC) of the uterine cervix is rare, and its etiology is unclear, except for reports of prenatal diethylstilbestrol (DES) exposure. In this case report of a 78-year-old postmenopausal Japanese woman with pelvic endometriosis, cervical CCC presented as a deep interstitial tumor, strongly suggesting the patient suffered from cervical endometriosis for a long time. A cystic lesion without solid components was detected in the uterine cervix. Although the patient had regular gynecological examinations every 6 months, she presented 5 years later with a complaint of watery vaginal discharge. Ultrasonography and magnetic resonance imaging (MRI) detected a uterine cervical cystic mass with a solid component. Although no malignancy was confirmed preoperatively, surgery was performed under a high suspicion of cervical cancer. Intraoperative pathology revealed CCC in a solid tumor, so debulking surgery, including lymphadenectomy, was done. Endometrial tissue was found adjacent to the tumor, strongly suggesting the tumor arose from cervical endometriosis. Because endometriosis in ectopic sites carries a risk of carcinogenesis, as is the case in ovarian endometriosis, it may be recommended that a cervical cystic lesion with pelvic endometriosis should be followed up regularly for the early detection of uterine cancer.

关键词： Cancer clear cell carcinoma Endometriosis Uterine Cervix

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Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor:A case report

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World Journal of Clinical Oncology 2020年第12期11卷 1076-1083页

作者： Zhi-Xiong Hu Min-Hua Tan Qiong-Zhen Li Jia-Li Xu Wei Chen Zhi-Hao Xie Yong-Jian Zhou Qing Liang Jian-Hong An Hong Shen Department of Pathology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Gynaecology and Obstetrics The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Radiology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Department of Pathology Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND To investigate the clinicopathological features of endometrial clear cell carcinoma that has invaded the right oviduct with a cooccurring ipsilateral oviduct adenomatoid *** SUMMARY A case of endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor was collected and analyzed using pathomorphology and *** clear cell carcinoma cells were distributed in a solid nest,papillary,shoe nail-like,and glandular tube-like *** was infiltrative growth,and tumor cells had clear cytoplasm and obvious nuclear *** cancer tissue was necrotic and *** cancer tissue invaded the right *** ipsilateral oviduct also had an adenomatoid *** adenomatoid tumor was arranged in microcapsules lined with flat or cubic cells that were surrounded by smooth muscle *** adenomatoid tumor cells were round in *** clear cell carcinoma of the endometrium can invade the oviduct and occur simultaneously with tubal adenomatoid *** pathological diagnosis,one should pay close attention to distinguishing whether an endometrial clear cell carcinoma is invading the oviduct or whether it is accompanied by an adenomatoid tumor of the *** is helpful to differentiate these two disease *** clear cell carcinomas express Napsin-A and P16 and are negative for estrogen receptor and progesterone *** presence of endometrial clear cell carcinoma does not affect the expression of CK and calretinin in adenomatoid tumors.

关键词： Endometrium clear cell carcinoma Oviduct Adenomatoid tumors Differential diagnosis Case report

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Spontaneous Regression of clear cell carcinoma of the Endometrium

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Journal of Cancer Therapy 2016年第9期7卷 635-645页

作者： Ketevani Kankava Alexi Baidoshvili Eltjo Schutter Sytske Van der Meer David Makaridze Department of Pathology N. Kipshidze Central University Clinic Tbilisi Georgia Department of Pathology Laboratory of Pathology Oost Nederland Hengelo The Netherlands Department of Obstetrics & Gynaecology Medisch Spectrum Twente Enschede The Netherlands Department of Psychiatry Mediant Locatie Helmerzijde Enschede The Netherlands

This report documents a rare case of complete spontaneous regression of clear cell carcinoma of the endometrium. An elderly woman with paranoid schizophrenia was admitted to the hospital because of vaginal bleeding. Diagnostic curetting and biopsy were performed and she was diagnosed with clear cell carcinoma of endometrium. Anti-tumour therapy was not possible because of her poor psychiatric status. 13 months later the woman died of a natural cause and at autopsy the endometrial tumour could no longer be identified. Myocardial infarction, aggravated by poor functional status of organism due to sepsis, was concluded to be the cause of death.

关键词： Gynaecological Cancer Pathology Spontaneous Regression clear cell carcinoma Endometrial Cancer Glucose Metabolism

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Primary clear cell carcinoma of the Thymus and Literature Comparison of Features

Primary Clear Cell Carcinoma of the Thymus and Literature Co...

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2020年浙江省医学会病理学术大会

作者： Xiaomin Dai HaiTao Yang Fang Peng Department of Pathology Zhejiang Hospital Department of Pathology Zhejiang Mingzhou Hospital

clear cell carcinoma arising from the thymus is considered exceedingly *** shows aggressive clinical behavior and demonstrates frequent local recurrences as well as widespread *** detailed clinical data of one patient with thymic clear cell carcinoma were compiled and review of relevant reported literatures was *** summarized the clinical characteristics,pathological diagnosis of this patient and other reported *** analysis showed that older male patients were more likely to suffer,the manifestations included chest pain and *** patients are asymptomatic,with the tumor being discovered during physical ***,thymic clear cell carcinoma is composed of lobulated structures arranged in hyperchromatic fibrous stroma,the tumor cells are uniform with obvious nucleoli and clear *** establish the correct diagnosis,consideration and exclusion of metastasis and other original tumors in the differential diagnosis by immunohistochemistry,clinical and radiologic correlation is important.

关键词： Thymic carcinoma clear cell carcinoma differential diagnosis

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Primary clear cell carcinoma of the nasopharynx:a case report

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The Chinese-German Journal of Clinical Oncology 2010年第8期9卷 493-494页

作者： FangzhengWang ZhenfuFu Department of Radiation Oncology Zhejiang Tumor Hospital Hangzhou 310022 China

Primary clear cell carcinoma of the nasopharynx is a rare and locally invasive minor salivary gland neoplasm,only two cases have been reported yet in the *** a 57-year man,with primary nasopharyngeal clear carcinoma,received radiotherapy and *** treatment,the mass of nasopharynx visibly ***-up two months and repeated MRI,CT,abdominal B-ultrasonograpy,electronic nasopharyngoscopy,no tumor recurrence or metastasis.

关键词： nasopharyngeal carcinoma clear cell carcinoma

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clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma:Case report with molecular analysis

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World Journal of Gastroenterology 2008年第42期14卷 6575-6577页

作者： Marta Barisella Andrea Lampis Federica Perrone Antonino Carbone Anathomic Pathology Department of Pathology Fondazione IRCCS Istituto Nazionale dei Tumori Milano 20133 Italy Experimental Molecular Pathology Department of Pathology Fondazione IRCCS Istituto Nazionale dei Tumori Milano 20133 Italy

Here we report a new case of clear cell adenocarcinoma (CCA) of the colon in a 54-year-old Caucasian man. Despite of the previous reported cases, the lesion was located in the right colon and was not associated with the conventional adenoma. We performed immunohistochemical and molecular analyses in order to explore whether the CCA had the molecular features generally associated with conventional colorectal carcinoma. The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma.

关键词： clear cell carcinoma Colon carcinoma Beta-catenin KRAS Molecular analysis

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Metastatic clear cell renal cell carcinoma in isolated retroperitoneal lymph node without evidence of primary tumor in kidneys: A case report

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World Journal of Clinical Oncology 2020年第2期11卷 103-109页

作者： Lisa BE Shields Arash Rezazadeh Kalebasty Norton Neuroscience Institute Norton HealthcareLouisvilleKY 40202United States Norton Cancer Institute Norton HealthcareLouisvilleKY 40202United States

BACKGROUND Retroperitoneal lymph node dissection(RPLND)plays a diagnostic,therapeutic,and prognostic role in myriad urologic malignancies,including testicular carcinoma,renal cell carcinoma(RCC),and upper urinary tract urothelial *** represents 2%of all cancers with approximately 25%of patients presenting with advanced *** cell RCC(CCRCC)is the most common RCC,accounting for 75%-80%of all *** SUMMARY A 71-year-old man presented with a history of benign prostatic *** was asymptomatic without any hematuria,pain,or other urinary symptoms.A computed tomography(CT)scan of the abdomen and pelvis showed a 1.8 cm left retroperitoneal lymph *** was no evidence of renal pathology.A core biopsy was performed of the left para-aortic lymph *** the primary tumor site was unknown,the morphological and immunohistochemical features were most consistent with CCRCC.A RPLND was performed which revealed a single mass 5.5 cm in greatest dimension with extensive *** retroperitoneal lymph node was most compatible with CCRCC.A nephrectomy was not conducted as a renal mass had not been detected on any prior imaging *** patient did not receive any type of adjuvant *** patient underwent surveillance with serial CT scans with contrast of the chest,abdomen,and pelvis for the next 5 years,all of which demonstrated no recurrent or metastatic disease and no evidence of retroperitoneal *** Our unique case emphasizes the therapeutic role of metastasectomy in metastatic CCRCC even in the absence of primary tumor in the kidneys.

关键词： Oncology Renal cell carcinoma clear cell carcinoma Lymph node dissection Retroperitoneal Metastasis Nephrectomy without primary site Case report

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The Expression and Significance of Her-2 and PTEN Proteins in clear cell Renal cell carcinoma in High Altitude Area

The Expression and Significance of Her-2 and PTEN Proteins i...

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第十五届全国泌尿外科学术会议

作者： Wangjian Lining Department of Urology, Qinghai University Affiliated Hospital 810001

Objective :To investigate the expression and the biological significance of Her-2 and PTEN proteins in patients with clear cell renal cell carcinoma(CCRCC)in high altitude area. Methods: Immunohistochemical S-P method... 详细信息

关键词： high altitude Renal clear cell carcinoma Her-2 Proteins PTEN Proteins

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