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Mechanism of yinchenhao decoction in the treatment of jaundice based on network pharmacology

Drug Combination Therapy 2020年第4期2卷 171-184页

作者： Nan Zhang Shu-Ying Zhang Wei-Yi Sun Department of General Surgery First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina Hexing Town Health Center Suiping CountyZhumadian CityChina

Objective:This study aimed to examine the mechanism of classic ancient prescription of chinese medicine yinchenhao decoction in treating jaundice based on network ***:An oral bioavailability of≥30%,a drug likeness of≥0.18,and literature studies were used to screen for Yinchen(Artemisiae scopariae herba),Zhizi(Gardeniae fructus),Dahuang(Rhei radix et rhizome)in the chinese medicine System Pharmacology Database and Analysis *** active ingredient was introduced into the PubChem database to collect drug component targets and import into the Uniprot database for gene *** target gene of Yinchen(Artemisiae scopariae herba)was screened via Human Gene Database(GeneCards).Then,use the Cytoscape 3.7.2 software was used for network visualization analysis,and the R3.6.1 software was used for gene ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment ***:We collected a total of 47 active constituents of classic ancient prescription of chinese medicine yinchenhao decoction,of which 17 were related to jaundice;189,9 targets of jaundice were screened,of which 41 were interdigitated with the targets of classic ancient prescription of chinese medicine yinchenhao *** ontology functional enrichment analysis revealed 111 biological processes,14 cellular components,and 28 molecular functions,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed 34 Kyoto Encyclopedia of Genes and Genomes pathways including hepatocellular carcinoma,PI3K-Akt signaling pathway,HIF-1 signaling pathway,prolactin signaling pathway,and non-alcoholic fatty liver ***:Based on the network pharmacology,the analysis of jaundice and classic ancient prescription of chinese medicine yinchenhao decoction provides a novel idea and direction for the study of classic ancient prescription of chinese medicine yinchenhao decoction in the treatment of jaundice.

关键词： classic ancient prescription of chinese medicine yinchenhao decoction Network pharmacology Jaundice Mechanism of action

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