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Antiglycating effects of citrus flavonoids and associated mechanisms

Food Science and Human Wellness 2024年第5期13卷 2363-2372页

作者： Yunli Xiao Junfeng Shen Jianfeng Zhan Limin Guo Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources Huanggang Normal UniversityHuanggang 438000China Institute of Agro-Products Storage and Processing Xinjiang Academy of Agricultural SciencesUrumqi 830091China Department of Food Science Rutgers UniversityNew Brunswick 08901USA

Glycation of proteins and DNA forms advanced glycation end products(AGEs)causing cell and tissue dysfunction and subsequent various chronic diseases,in particular,metabolic and age-related *** AGE inhibition includes scavengers of reactive carbonyl species(RCS)such as methylglyoxal(MG),glyoxalase-1 enhancers,Nrf2/ARE pathway activators,AGE/RAGE formation inhibitors and other antiglycatng *** flavonoids have demonstrated antioxidant and anti-inflammatory effects and are also found to be effective antiglycating ***,we reviewed the up to date progress of the antiglycation effects of citrus flavonoids and associated *** citrus flavonoids,hesperedin and its aglycone,hesperetin,inhibited glycation by scavenging MG forming mono-or di-flavonoid adducts with MG,enhanced the activity of glyoxase-1,activated Akt/Nrf2 signal pathway while inhibiting AGE/RAGE/NF-κB pathway,reduced the formation of Nε-(carboxylmethyl)lysine(CML)and pentosidine,inhibited aldol reductase activity and decreased the levels of *** antiglycating activity and mechanisms of other flavonoids was also summarized in this *** conclusion,citrus flavonoids possess effective antiglycating activity via different mechanisms,yet there are many challenging questions remaining to be studied in the near future such as in vivo testing and human study of citrus flavonoids for efficacy,effectiveness and adverse effects of citrus flavonoids as a functional food in managing high levels of AGEs and controlling AGE-induced chronic diseases,diabetic complications in particular.

关键词： citrus flavonoids Hesperedin Advanced glycation end products Antiglycation Diabetic complication

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Inhibition of citrus flavonoids on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumorigenesis in mice

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Food Science and Human Wellness 2012年第1期1卷 65-73页

作者： Min-Hsiung Pan Shiming Li Ching-Shu Lai Yutaka Miyauchi Michiko Suzawa Chi-Tang Ho Department of Seafood Science National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA Miyauchi citrus Research Center 324-10 Shigoka-MachiTakasakiGunma 370-0845Japan

The inhibitory effects of a formulated product from citrus peel extract,Gold Lotion(GL),on 12-O-tetradecanoylphorbol 13-acetate(TPA)-induced expression of inducible nitric oxide synthase(iNOS)and cyclooxygenase-2(COX-2)in mouse skin was reported in this *** is found that in the TPA-induced skin inflammation model,the topical application of GL effectively inhibited the transcriptional activation of iNOS and its mRNA and protein in mouse *** is also discovered that GL significantly inhibited TPA-induced mouse skin inflammation by decreasing inflammatory gene ***,GL dramatically inhibited 7,12-dimethylbenez[a]anthracene(DMBA)/TPA-induced skin tumor formation and reduced tumor incidence,tumor weight and tumor multiplicity of papillomas at 20 *** essence,these in vivo data have revealed that GL is an effective anti-tumor agent that functions by down-regulating the protein levels of COX-2,ornithine decarboxylase(ODC),and vascular endothelial growth factor(VEGF)in mouse skin,suggesting that GL is a novel functional natural product capable of preventing inflammation-associated tumorigenesis.©2012 Production and hosting by Elsevier *** behalf of Beijing Academy of Food Sciences.

关键词： Inhibition Skin cancer citrus flavonoids Inflammation Tumorigenesis

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citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2

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Natural Products and Bioprospecting 2022年第1期12卷 41-50页

作者： Wenting Liu Weikang Zheng Liping Cheng Ming Li Jie Huang Shuzheng Bao Qiang Xu Zhaocheng Ma College of Horticulture and Forestry Sciences Key Laboratory of Horticultural Plant BiologyMinistry of EducationHuazhong Agricultural UniversityWuhan 430070China Network of Aquaculture Centres in Asia-Pacific Bangkok 10903Thailand China Association of Agricultural Science Societies Beijing 100125China

The most recent outbreak of 2019 novel coronavirus,named as COVID-19,caused pneumonia epidemic in Wuhan with 2121 deaths cases as of February 20th *** of effective antiviral agents to combat the novel coronavirus is urgently *** fruit peel or wild citrus are rich in flavonoids,and clinically documented for roles in relief of cough and promotion of digestive ***,citrus fruits are assumed to possess antivirus activities or enhance the host immunity.A previous study found that hesperetin could act as a high potent inhibitor of SARS-CoV *** determined six flavonoid compounds’content in three citrus species by using LC-MS *** content of naringin and naringenin was at higher levels in *** and hesperidin were highly accumulated in mandarin and sweet *** subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines(COX-2,iNOS,IL-1βand IL-6)induced by LPS in Raw macrophage cell line,and may restrain cytokine through inhibiting HMGB1 expression in a mouse *** results revealed that naringin may have a potential application for preventing cytokine *** simulated molecular docking to predict the binding affinity of those flavonoids to bind Angiotensin-converting enzyme 2(ACE 2),which is a receptor of the *** of the potential anti-coronavirus and anti-inflammatory activity of flavonoids,the citrus fruit or its derived phytochemicals are promising in the use of prevention and treatment of SARS-CoV-2 infection.

关键词： citrus flavonoids Naringin Immunoregulation ACE2 SARS-CoV-2

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Anti-inflammatory effects of characterized orange peel extracts enriched with bioactive polymethoxyflavones

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Food Science and Human Wellness 2014年第1期3卷 26-35页

作者： Alexander Gosslau Kuang Yu Chen Chi-Tang Ho Shiming Li Department of Science BMCC-City University of New YorkNew YorkNY 10007United States Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ 08854-8087United States Department of Food Science Rutgers UniversityNew BrunswickNJ 08901-8520United States College of Chemistry and Chemical Engineering Huanggang Normal UniversityHuanggang 438000China

In view of the potential of polymethoxyflavones(PMFs)and hydroxylated PMFs(OH-PMFs)as bioactives against inflammation,we prepared six different orange peel extracts(OPEs).The major compounds of these extracts were characterized and quantified by high performance liquid chromatography(HPLC).Effects on inflammation were analyzed by nutrigenomics using a human cell-based TPA-induced monocyte–macrophage differentiation model employing U-937 cells and inflammatory surrogate *** response and kinetics analysis of OPEs with different chemical profiles revealed less cytotoxic effects of PMFs as compared to OH-PMFs as demonstrated by the ***,a comparison of two PMF members such as 3,5,6,7,3,4-hexamethoxyflavone(HexaMF)and 3,5,6,7,8,3,4-heptamethoxyflavone(HeptaMF)exhibited less cytotoxic effects of HeptaMF as compared to HexaMF.A specific OPE enriched with HeptaMF,PMFs and OH-PMFs at low concentrations(10g/mL)significantly down-regulated the expression of a panel of genes involved in inflammatory response,including COX-2,TNF-α,ICAM-1,NFκB,IL-1β,IL-6,and IL-8 with an inflammatory index of−*** strong anti-inflammatory effects were then validated in a mouse carrageenan-induced paw edema *** intake of OPE reduced paw edema significantly in a dose-dependent ***,a dosage of 250 mg/kg gave an anti-inflammatory effect comparable to ibuprofen.A preliminary clinical study showed that OPE was well tolerated showing no adverse side *** summary,enrichment of phyto extracts such as OPEs with specific polymethoxyflavones as anti-inflammatory bioactives is a promising strategy to find naturally derived extracts that are effective against diseases associated with inflammation.©2014 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： citrus flavonoids Edema Gene expression Inflammation Nutrigenomics

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