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Role of the circulatory interleukin-6 in the pathogenesis of gliomas:A systematic review

World Journal of Methodology 2022年第5期12卷 428-437页

作者： Manish Singh Alok Raghav Kirti Amresh Gautam Department of Neurosurgery GSVM Medical CollegeKanpur 208001India Department of Basic and Applied Science GD Goenka UniversityGurugram 122103HaryanaIndia

BACKGROUND Glioma is the most common primary tumor in the brain originating from glial *** spite of extensive research,the overall survival rate is not enhanced.A number of published articles observed differentially circulating levels of cytokines in ***-6(IL-6)protein coded by IL-6 gene is regulated by the immune system and it has been found to have a significant role in progression and apoptosis resistance of *** To review the role of circulatory IL-6 in the development and progression of glioma and its utility as a *** Preferred Reporting Items for Systematic Reviews and Meta-analysis(PRISMA)guidelines were applied to filter the relevant studies based on inclusion and exclusion *** used a combination of keywords and the Reference Citation Analysis(RCA)tool to search the potential studies and performed data extraction from selected *** The published results were inconsistent;however,most studies showed a significantly higher IL-6 level in glioma cases as compared to *** IL-6 level among the different grades of glioma showed a higher level with low-grade gliomas and lower level with high-grade *** IL-6 level significantly differed between cases and controls,and among different cancer stages,which shows its potential as a diagnostic and prognostic marker.

关键词： Gliomas Interleukin-6 circulatory markers Diagnostic marker Prognostic marker

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