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A review of cell-type specific circuit mechanisms underlying epilepsy

Acta Epileptologica 2024年第2期7卷 75-86页

作者： Peilin Zhao Xiaomi Ding Lini Li Guohui Jiang Institute of Neurological Diseases Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China Nanomedicine Innovation Research and Development Transformation Institute Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China Department of Neurology Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China

Epilepsy is a prevalent neurological disorder,yet its underlying mechanisms remain incompletely ***-mulated studies have indicated that epilepsy is characterized by abnormal neural *** the circuit mechanisms is crucial for comprehending the pathogenesis of *** advances in tracing and modulating tools for neural circuits,some epileptic circuits have been *** comprehensive review focuses on the cir-cuit mechanisms underlying epilepsy in various neuronal subtypes,elucidating their distinct *** seizures are primarily characterized by the hyperactivity of glutamatergic neurons and inhibition of GABAergic ***-ever,specific activated GABAergic neurons and suppressed glutamatergic neurons exacerbate epilepsy through pref-erentially regulating the activity of GABAergic neurons within epileptic *** subtypes of GABAergic neurons contribute differently to epileptic activities,potentially due to their diverse connection ***,identical GABAergic neurons may assume distinct roles in different stages of *** GABAergic neurons and glutamatergic neurons with long-range projecting fibers innervate multiple nuclei;nevertheless,not all of these circuits contribute to epileptic *** circuits originating from the same nuclei may display diverse con-tributions to epileptic activities,and certain glutamatergic circuits from the same nuclei may even exert opposing effects on *** neurons,including cholinergic,serotonergic,dopaminergic,and noradrenergic neurons,are also implicated in epilepsy,although the underlying circuit mechanisms remain poorly *** studies suggest that epileptic nuclei establish intricate connections through cell-type-specific circuits and play pivotal roles in ***,there are still limitations in knowledge and methods,and further understanding of epileptic circuits is crucial,particularly in the context of

关键词： Epilepsy circuit mechanisms Cell-type specific Neuromodulatory

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