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The quality control and hypoglycemic effect of cinnamomi cortex aqueous extract

Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng Jin Ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China Department of Food Science Rutgers University New BrunswickNJ 08901USA Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

cinnamomi cortex was a material as medicinal and edible resources and it has been demonstrated that cinnamomi cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic ***,in this study,the quality standard and the hypoglycemic effect of CCAE were *** and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)*** results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,*** investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)*** results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： cinnamomi cortex Cinnamaldehyde Coumarin Hypoglycemic effect

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Quantification of seven phenylpropanoid compounds in Chinese cinnamomi cortex and Ramulus by HPLC

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Journal of Chinese Pharmaceutical Sciences 2015年第9期24卷 591-599页

作者：袁鹏飞马雅静苏丹尚明英徐风刘广学 Niloufar Iranmanesh 李兰芳姜廷良蔡少青北京大学医学部药学院生药学研究室北京100191 加利佛尼亚大学洛杉矶分校生理学系美国洛杉矶90095 中国中医科学院中药研究所北京100700

In the present study, we developed and validated a high-performance liquid chromatography method for the simultaneous determination of seven phenylpropanoid compounds （2-hydroxyl cinnamaldehyde, coumarin, cinnamyl alcohol, cinnamic acid, 2-methoxy cinnamic acid, cinnamaldehyde and 2-methoxy cinnamaldehyde） in cinnamomi cortex and cinnamomi Ramulus. The levels of seven phenylpropanoid compounds in cinnamomi cortex and cinnamomi Ramulus were compared using this method. A total of 48 samples （27 cinnamomi cortex and 21 cinnamomi Ramulus） were purchased in China and analyzed. Quantities of seven phenylpropanoid compounds ranged from 17.5 to 61.6 mg/g in cinnamomi cortex and ranged from 9.91 to 23.4 mg/g in Ciunamomi Ramulus. The level of 2-methoxy cinnamic acid in the cinnamomi cortex samples was below the LOD, whereas it ranged from 0 to 0.119 mg/g in the cinnamomi Ramulus samples. The （cinnamyl alcohol＋cinnamic acid）/cinnamaldehyde ratios （R346） of Ciunamomi cortex and cinnamomi Ramulus ranged from 0.0121 to 0.0467 and 0.0598 to 0.182, respectively. This ratio could be used to discriminate cinnamomi cortex （〈0.05） and cinnamomi Ramulus （〉0.05）. The extraction rates （Dn） of seven compounds in boiling water were different, with the lowest dissolution for cinnamaldehyde （〈3%） and the highest for cinnamic acid （about 60%）.

关键词： Quantification Phenylpropanoid compounds cinnamomi cortex cinnamomi Ramulus High-performance liquid chromatography

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