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Cimicifuga heracleifolia is therapeutically similar to black cohosh in relieving menopausal symptoms: evidence from pharmacological and metabolomics studies

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Chinese Journal of Natural Medicines 2019年第6期17卷 435-445页

作者： MIAO Lan-Yun CHU Thi Thanh Huyen LI Ping JIANG Yan LI Hui-Jun State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China

In the market of botanical dietary supplements, Cimicifuga heracleifolia(CH) has always been considered as an adulterated species of Cimicifuga racemosa(CR), a conventional American herb with promising benefits to counteract troubles arising from the menopause. However, the detailed comparison of their therapeutic effects is lacking. In present study, the pharmacological and metabolomics studies were comparatively conducted between CH and CR in ovariectomized(OVX) female rats. Specifically, estrogen-like, anti-hyperlipidemia and anti-osteoporosis effects were evaluated through measuring serum biochemical parameters, histopathological examination and micro computed tomography(Micro-CT) scanning. At the same time, a gas chromatography-mass spectrometry(GC-MS)-based serum metabolomics method was employed to profile the metabolite compositional changes. As a result, both CR and CH displayed anti-osteoporosis and anti-hyperlipemia on menopause syndrome. Meanwhile, their potentials in improving the OVX-induced metabolic disorders were discovered. In conclusion, these results demonstrated that CH is therapeutically similar to CR in relieving menopausal symptoms and CH could be considered as a promising alternative to CR instead of an adulterant in the market of botanical dietary supplements.

关键词： Cimicifuga heracleifolia Black cohosh Menopausal symptoms Metabolomics Substitute

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Development and Characterization of Microsatellite Markers for Three Pollination Morphs of <i>Cimicifuga simplex</i>(Ranunculaceae)

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American Journal of Plant Sciences 2018年第4期9卷 599-605页

作者： Tsubasa Toji Yoshiaki Kameyama Akira S. Hirao Takao Itino Graduate School of Science and Technology Shinshu University Matsumoto Japan Faculty of Regional Environment Science Tokyo University of Agriculture Tokyo Japan Sugadaira Research Station Mountain Science Center University of Tsukuba Tsukuba Japan Department of Biology and Institute of Mountain Science Shinshu University Matsumoto Japan

Cimicifuga simplex Wormsk. (Ranunculaceae) is a perennial herb distributed in eastern and northeastern Asia for which at least three different pollination morphs have been reported. It is classified as endangered or near threatened in some Japanese regions, and its rhizome is commercially used as a crude drug. To examine genetic differentiation and gene flow among the three morphs, we developed eight microsatellite markers by using next-generation sequencing and estimated the genetic structure of C. simplex. We tested eight primer pairs on 93 individuals from six populations of C. simplex in Nagano, central Japan, and found that heterozygosity in morphs I and III was low compared to expected heterozygosity. Bayesian clustering performed with the STRUCTURE program clearly distinguished the three morphs of C. simplex, and only a little gene flow was detected among the morphs. These eight microsatellite markers are expected to be useful in conservation genetic studies of this species and for future conservation planning.

关键词： Cimicifuga simplex Genetic Structure Microsatellite Marker Next-Generation Sequencing Pollination Morph

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Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS

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Acta Pharmaceutica Sinica B 2017年第2期7卷 185-192页

作者： Mengxue Fan Kunming Qin Fei Ding Yuting Huang Xiaoli Wang Baochang Cai Engineering Research Center of Ministry of Education for Standardization of Chinese Medicine Processing Nanjing University of Chinese Medicine Nanjing Haichang Chinese Medicine Group Co.Ltd.

Cimicifugae Rhizoma(Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China,has been widely used in traditional Chinese medicine.The Pharmacopoeia of the People's Republic of China contains three varieties(Cimicifuga dahurica(Turcz.),Cimicifuga foetida L.and Cimicifuga heracleifolia Kom.) which have been used clinically as "Sheng-ma".However,the chemical constituents of three components of "Sheng-ma" have never been documented.In this study,a rapid method for the analysis of the main components of "Sheng-ma" was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry(UPLC/Q-TOF-MS).The present study reveals the major common and distinct chemical constituents of C.dahurica,C.foetida and C.heracleifolia and also reports principal component and statistical analyses of these results.The components were identified by comparing the retention time,accurate mass,mass spectrometric fragmentation characteristic ions and matching empirical molecular formula with that of the published compounds.A total of 32 common components and 8 markers for different "Sheng-ma" components were identified.These findings provide an important basis for the further study and clinical utilities of the three "Sheng-ma" varieties.

关键词： Sheng-ma Chemical profiling UPLC/Q-TOF-MS Chemical marker Cimicifuga Cimicifugae Rhizoma

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