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Psychiatric comorbidities in children and adolescents with chronic urticaria

World Journal of Pediatrics 2023年第4期19卷 315-322页

作者： George N.Konstantinou Gerasimos N.Konstantinou Department of Allergy and Clinical Immunology 424 General Military Training HospitalThessaloníkiGreece Department of Psychiatry University of TorontoTorontoONCanada Center for Addiction and Mental Health(CAMH) TorontoONCanada

Background chronic urticaria(CU)has been shown to impact patients'quality of life negatively and may coexist with psychiatric disorders.We systematically reviewed the published evidence of comorbid psychiatric disorders in children and adolescents with CU.Methods A systematic review of studies published until February 2022 in PubMed,Google Scholar,and Scopus was performed.An a priori set of inclusion criteria was predefined for the studies to be included:(1)clear distinction between urticaria and other allergies;(2)precise distinction between acute and CU;(3)participants younger than 18 years old,exclusively;(4)use of appropriate standardized questionnaires,psychometric tools,and standard diagnostic nomenclature for the mental health and behavioral disorders diagnosis;and(5)manuscripts written or published in the English language.Results Our search identified 582 potentially relevant papers.Only eight of them satisfied the inclusion criteria.Quantita-tive meta-analysis was not deemed appropriate,given the lack of relevant randomized control trials,the small number of relevant shortlisted,the small sample size of the patients included in each study,and the remarkable heterogeneity of the studies'protocols.Conclusions The included studies suggest an increased incidence of psychopathology among children and adolescents with CU as opposed to healthy age-matched individuals,but the data are scarce.Further research is required to clarify whether psychopathology is just a comorbid entity,the cause,or the consequence of CU.Meanwhile an interdisciplinary collaboration between allergists/dermatologists and psychiatrists is expected to substantially minimize CU burden and improve patients'quality of life.

关键词： Adolescents Children chronic urticaria Psychiatry Psychopathology Quality of life

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Effectiveness and safety of acupoint catgut embedding combined with Chinese herbal medicine in chronic urticaria: A systematic review of randomized controlled trials

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 365-373页

作者： Weiying Xing Xuan Wang Ying Zhang Wentao Zhu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Galactophore The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing100029China Center for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing102488China School of Management Beijing University of Chinese MedicineBeijing102488China

Objective:To evaluate the effectiveness and safety of acupoint catgut embedding(ACE)in combination with Chinese herbal medicine(CHM)in treating chronic urticaria(CU).Methods:We thoroughly searched Embase,PubMed,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),Wangfang database,Chinese Scientific Journal Database(VIP),and Chinese biomedical literature database(SinoMed)for relevant studies from inception until May 2022.Randomized controlled trials(RCTs)on ACE combined with CHM for CU were included.Literature search,data extraction,and risk of bias assessment were independently conducted by two authors.Results:A total of 15 RCTs with 1065 participants were included in this review.Five trials reported that the combined therapy showed a higher total effective rate,and four trials reported that the combined therapy was associated with a lower level of serum immunoglobulin E.Furthermore,two,four,and four trials reported that the combined therapy was more effective in reducing itching degree,size,and number of wheals,respectively.The combined therapy was reported to be associated with a lower recurrence rate in three trials,and with a fewer adverse reaction rate in two trials.Conclusions:ACE in combination with CHM appears to be a safe and effective therapy for patients with CU.Given the relatively low quality of the included trials,these findings should be interpreted cautiously.Further high-quality RCTs are needed to confirm our findings.

关键词： Acupoint catgut embedding Chinese herbal medicine chronic urticaria Systematic review

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Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis

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Journal of Integrative Medicine 2020年第4期18卷 303-312页

作者： Xian-jun Xiao Lei-xiao Zhang Yun-zhou Shi Jun-peng Yao Wei Cao Ying Liu Zi-hao Zou Si-yuan Zhou Ming-ling Chen Chun-xiao Li Qian-hua Zheng Ying Li Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Rehabilitation Department the People’s Hospital of Jianyang CityChengdu 641400Sichuan ProvinceChina Dermatological Department Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Graduate School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina

Background:chronic urticaria(CU)is a common skin disease,which has a negative effect on quality of life.Current treatments do not fully control the symptoms of urticaria for many CU patients,thus effective and safe treatments for CU are still needed.Objective:This review aims to evaluate the effectiveness and safety of cupping therapy in patients with CU.Search strategy:The search strategy looked for the presence of related keywords,such as‘‘chronic urticaria"and‘‘cupping therapy,"in the title and abstract of research articles indexed in major databases.Randomized controlled trials(RCTs)were selected after querying nine electronic databases from their inception to May 2019 with the above search terms.Inclusion criteria:RCTs were included if they recruited patients with CU who were intervened with dry or wet cupping.Publications could be written in Chinese or English.Data extraction and analysis:Data were extracted,and the studies were assessed for the quality of their methodological design and risk of bias.Meta-analyses of the RCT data were conducted to assess the total effective rate of the treatment as the primary outcome.Skin disease quality of life index score,recurrence rate,and adverse events were assessed as secondary outcomes.Subgroup analyses were conducted based on different interventions.Results:Thirteen comparisons from 12 RCTs involving 842 participants were included.There were no significant differences between wet cupping and medications in total effective rate(n=372;risk ratio[RR]=1.10,95%confidence interval[CI]0.97 to 1.25;P=0.14)or recurrence rate(n=240;RR=0.56,95%CI 0.23 to 1.36;P=0.20).Cupping therapy,in combination with antihistamine treatment was more efficacious than antihistamines alone,with a greater total effective rate(n=342;RR=1.18,95%CI 1.01 to1.39;P=0.03)and lower recurrence rate(n=342;RR=0.52,95%CI 0.32 to 0.84;P=0.007).Cupping therapy combined with acupuncture was more effective than acupuncture alone(n=156;RR=1.25,95%CI 1.07 to 1.46;P=0.006).No serious adverse events were reported

关键词： Cupping chronic urticaria Systematic review Meta-analysis Antihistamines Acupuncture

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Evidence-Based Therapies of Chinese Medicine for chronic urticaria:Where Do We Stand and Where Are We Going?

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Chinese Journal of Integrative Medicine 2017年第8期23卷 566-569页

作者： WANG Yong-ming DU Lin ZHU Yuan-jie Department of Dermatology The Second People's HospitalBengbu Department of Dermatology Changzheng HospitalThe Sencond Military Medical University

chronic urticaria（CU）is characterized by repeated occurrence of wheals or itching for more than 6 weeks.When urticaria symptoms repeatedly occur despite taking Western medicines such as antihistamines,Chinese medicine（CM）has been shown to relieve symptoms and prevent recurrence.However,the lack of robust evidence from the evidence-based medicine perspective is hindering acceptance of CM by the Western medicine community.In recent years,more and more evidence-based studies of CU treatment by CM were report in English literatures,including acupuncture,herbs,and food,although some of evidence is still with low quality.These progress in CM treatment of CU will inspire high quality evidences via randomized,controlled trials assessing efficacy and safety of CM treatment of CU.

关键词： chronic urticaria Chinese medicine evidence-based medicine treatment

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chronic urticaria Due to Allergy to Wheat Alpha-Amylase Inhibitor Proteins

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Case Reports in Clinical Medicine 2016年第4期5卷 130-133页

作者： Nagore Arruti Oyarzabal Olga Villarreal Balza de Vallejo Nagore Bernedo Belar Maria Teresa Audicana Berasategui Natividad Longo Areso Borja Bartolomé Servicio de Alergia e Inmunología Clínica Hospital Universitario Araba Vitoria-Gasteiz Spain Bial-Aristegui Laboratories Bilbao Spain

chronic spontaneous urticaria (CSU) is defined as the spontaneous appearance of wheals, angioedema, or both, for at least 6 weeks, due to known or unknown causes [1]. In some patients who present a CSU with daily or almost daily symptoms a type I allergy could be the underlying cause. We present one adult patient with chronic urticaria who was finally diagnosed as a non-occupational case of IgE-mediated wheat allergy manifested following exposure by 3 different routes: inhalation (rhinitis and bronchial asthma), dermal absorption (contact urticaria) and ingestion (systemic chronic urticaria). We were able to detect the culprit proteins by immunoblotting. Serum IgE binds mainly to alpha-amylase/trypsin inhibitors and, to a lesser extent, to other proteins associated with food allergy to grains (e.g. beta-glucanase, serpin, peroxidase). In our opinion, skin prick tests with a food standard battery could help in the etiological diagnosis of chronic urticaria. The identification of responsible allergens could be difficult because only a few complex in vitro techniques allow detecting the allergy to several proteins.

关键词： Alpha-Amylase Inhibitor Wheat chronic urticaria Allergy

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Based on data mining,the drug law of clinical treatment of chronic urticaria

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Medical Data Mining 2021年第1期4卷 38-47页

作者： Hai-Ping Duan Ming-Kai Wang Hai-Die Liu Yu-Rong Zhao Li-Feng Wang Yunnan University of Traditional Chinese Medicine Kunming 650500China First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine/Yunnan Hospital of Traditional Chinese Medicine Kunming 650021China

Background:Based on clinical data mining,we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria,as the reference of clinical treatment of chronic urticaria.Methods:we collected 110 traditional Chinese medicine prescriptions for the treatment of chronic urticaria,and found out tastes,functions and channel tropism of Chinese medicine.After collecting and sorting,we inputted the data into excel 2010 software and established drug electronic database.We calculated the frequency of tastes,functions and channel tropism using the Spss 20.0 and analyzed the potential relationship between the drugs using Weka 3.8.We used Cytoscape 3.6.1 to draw the related network and combine it into a new prescription.Then the clinical data of prescriptions were statistically analyzed.Results:The statistical analysis showed that the high-frequency drugs for the treatment of the disease were Gancao(Glycyrrhizae radix et rhizoma),Huangqin(Radix scutellariae),Desmopeel,Jingjie(Herba schizonepetae),parsnip,etc.,accounting for more than 69.50%of the total frequency.Moreover,the combination and drug pairs with the strongest and most commonly used high-frequency drugs were found.From the point of medicinal properties of these drugs in the treatment of chronic urticaria,the main drugs are cold,followed by warm and smooth,accounting for 70.75%of the total frequency.From the perspective of the efficacy of these drugs in the treatment of chronic urticaria,heat-clearing drugs are the main ones,followed by relieving drugs and Tonic drugs,accounting for 68.25%of the total frequency.From the perspective of medicine taste,sweet taste is the most important,followed by bitter and pungent taste,accounting for 68.00%of the total frequency.From the perspective of drugs channel tropism,the meridian of spleen is the most important,followed by the meridian of lung,liver,heart,stomach,etc.,accounting for 71.62%of the total frequency.Conclusion:According to the data mining results,traditional Chinese

关键词： chronic urticaria Data mining Traditional Chinese medicine Treatment Drug law

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Elevated total IgE in serum of patients with chronic urticaria may indicate insensitive to antihistamine treatment

Elevated total IgE in serum of patients with chronic urticar...

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第十一届全国免疫学学术大会

作者： Han Yue Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College

Objective:Previous studies proved that serum total Ig E(t Ig E)was elevated in patients with chronic urticaria(CU),however,the relationship between the serum level of total Ig E and the pathogenesis of CU still needs to be further explored.The aim of this study is to investigate the relationship between elevated serum level of t Ig E in patients with CU and sensitivity of patients to antihistamine treatments.

关键词： chronic urticaria tIgE antihistamine

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