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Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission

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Bioactive Materials 2023年第8期26卷 323-336页

作者： Yue Zhang Meng Li Yunchuan Wang Fei Han Kuo Shen Liang Luo Yan Li Yanhui Jia Jian Zhang Weixia Cai Kejia Wang Ming Zhao Jing Wang Xiaowen Gao Chenyang Tian Baolin Guo Dahai Hu Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical University127 Changle West RoadXi’anShaanxi710032China State Key Laboratory for Mechanical Behavior of Materials And Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an710049China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710049China

chronic diabetic wounds remain a globally recognized clinical *** occur due to high concentrations of reactive oxygen species and vascular function disorders.A promising strategy for diabetic wound healing is the delivery of exosomes,comprising bioactive *** activates the vascular endothelial growth factor pathway,thereby improving angiogenesis in hyperglycemic ***,multifunctional hydrogels loaded with drugs and bioactive substances synergistically promote wound repair has been rarely reported,and the mechanism of their combinatorial effect of exosome and metformin in wound healing remains ***,we engineered dual-loaded hydrogels possessing tissue adhesive,antioxidant,self-healing and electrical conductivity properties,wherein 4-armed SH-PEG cross-links with Ag^(+),which minimizes damage to the loaded goods and investigated their mechanism of promotion effect for wound *** carbon nanotubes exhibiting good conductivity were also incorporated into the hydrogels to generate hydrogen bonds with the thiol group,creating a stable three-dimensional structure for exosome and metformin *** diabetic wound model of the present study suggests that the PEG/Ag/CNT-M+E hydrogel promotes wound healing by triggering cell proliferation and angiogenesis and relieving peritraumatic inflammation and vascular *** mechanism of the dual-loaded hydrogel involves reducing the level of reactive oxygen species by interfering with mitochondrial fission,thereby protecting F-actin homeostasis and alleviating microvascular ***,we propose a drug-bioactive substance combination therapy and provide a potential mechanism for developing vascular function-associated strategies for treating chronic diabetic wounds.

关键词： Dual-loaded hydrogels Adipose-derived mesenchymal stem cell exosomes Metformin Angiogenesis Mitochondrial fission chronic diabetic wound wound healing

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Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment

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Bioactive Materials 2021年第11期6卷 3962-3975页

作者： Yuxuan Yang Xiaodan Zhao Jing Yu Xingxing Chen Ruyue Wang Mengyuan Zhang Qiang Zhang Yanfeng Zhang Shuang Wang Yilong Cheng Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710049China School of Chemistry Xi’an Jiaotong UniversityXi’an710049China

The treatment of diabetic chronic wounds remains a global challenge due to the up-regulated inflammation response,oxidant stress,and persistent infection during healing *** wound dressing materials with ideal biocompatibility,adequate mechanical strength,considerable under-water adhesion,sufficient anti-inflammation,antioxidant,and antibacterial properties is on-demand for clinical *** this study,we developed a bioactive skin-mimicking hydrogel band-aid through the combination of tannic acid(TA)and imidazolidinyl urea reinforced polyurethane(PMI)(TAP hydrogel)and explored its potentials in various medical applications,including hemostasis,normal skin incision,full-thickness skin wounds,and bacterial-infection skin incision on diabetic *** was loaded into PMI hydrogel network to enhance the mechanical properties of TAP hydrogels through multiple non-covalent interactions(break strength:0.28-0.64 MPa;elongation at break:650-930%),which could resist the local stress and maintain the structural integrity of wound dressings during ***,owing to the promising moisture-resistant adhesiveness and organ hemostasis,outstanding anti-inflammation,antibacterial,and antioxidant properties,TAP hydrogels could efficiently promote the recovery of skin incision and defects on diabetic *** further simulate the practical situation and explore the potential in clinical application,we also verified the treatment efficiency of TAP hydrogel in ***-infected skin incision model on diabetic mice.

关键词： Hydrogel Tannic acid wound dressing chronic diabetic wound Hydrogen bonding

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