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Glucose supplementation improves intestinal amino acid transport and muscle amino acid pool in pigs during chronic cold exposure

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Animal Nutrition 2023年第1期12卷 360-374页

作者： Teng Teng Xin Song Guodong Sun Hongwei Ding Haoyang Sun Guangdong Bai Baoming Shi Institute of Animal Nutrition Northeast Agricultural UniversityHarbin 150030China

Mammals in northern regions chronically suffer from low temperatures during autumn-winter *** aim of this study was to investigate the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure via Min pig models(cold adaptation)and Yorkshire pig models(non-cold adaptation).Furthermore,this study explored the beneficial effects of glucose supplementation on small intestinal amino acid transport and amino acid pool in muscle of cold-exposed Yorkshire *** pigs(Exp.1)and Yorkshire pigs(Exp.2)were divided into a control group(17℃,n=6)and chronic cold exposure group(7℃,n=6),*** Yorkshire pigs(Exp.3)were divided into a cold control group and cold glucose supplementation group(8℃).The results showed that chronic cold exposure inhibited peptide transporter protein 1(PepT1)and excitatory amino acid transporter 3(EAAT3)expression in ileal mucosa and cationic amino acid transporter-1(CAT-1)in the jejunal mucosa of Yorkshire pigs(Pchronic cold exposure,accompanied by increased muscle RING-finger protein-1(MuRF1)and muscle atrophy F-box(atrogin-1)expression(Pchronic cold exposure and glucose supplementation,glucose supplementation improved CAT-1 expression in the jejunal mucosa and PepT1 expression in the ileal mucosa of cold-exposed Yorkshire pigs(Pchronic cold exposure inhibits amino acid absorption in the small intestin

关键词： chronic cold exposure Amino acid transporter Branched amino acid Protein deposition Glucose Pig

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Stress injuries and autophagy in mouse hippocampus after chronic cold exposure

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Neural Regeneration Research 2017年第3期12卷 440-446页

作者： Ting-ting Qu Jie-xin Deng Rui-ling Li Zhan-jun Cui Xiao-qing Wang Lai Wang Jin-bo Deng Institute of Neurobiology College of Life ScienceHenan University Nursing College Henan Vocational College of Applied Technology

cold exposure is an external stress factor that causes skin frostbite as well as a variety of *** might participate in neuroprotection after cold exposure,but its precise mechanism remains *** this study,mice were exposed to 10°C for 7 days and 0–4°C for 30 days to induce a model of chronic cold *** showed that oxidative stress-related c-fos and cyclooxygenase 2 expressions,MAP1LC3-labeled autophagic cells,Iba1-labeled activated microglia,and interleukin-1β-positive pyramidal cells were increased in the hippocampal CA1 *** cold exposure markedly elevated the levels of estrogen in the blood and the estrogen receptor,G protein-coupled receptor *** results indicate that neuroimmunoreactivity is involved in chronic cold exposure-induced pathological alterations,including oxidative stress,neuronal autophagy,and ***,estrogen exerts a neuroprotective effect on cold exposure.

关键词： nerve regeneration chronic cold exposure oxidative stress autophagy microglial cells neuroimmunoreactivity hippocampal CA1 area estrogen neural regeneration

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