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A Prospective Study of Inpatient Ketamine Subanaesthetic Dose Infusion in chronic refractory pain

pain Studies and treatment 2021年第3期9卷 17-35页

作者： Teik Guan Tay Tony Hollins Ben Teo Kok Eng Khor James Tekiko Department of pain Management Prince of Wales Hospital Sydney Australia Prince of Wales Clinical School University of New South Wales Sydney Australia

Background: Inpatient subanaesthetic ketamine infusion for 5 days may improve pain and reduce oral opioid usage in patients with chronic pain. Objective: This study aims to investigate pain and psychological outcomes of ketamine parenteral infusion (0.1 - 0.35 mg/kg/h or maximum 24 mg/hour) for 5 days in patients with chronic refractory pain. The secondary objective is to explore any prognostic pain and psychological factors associated with the successful response to the ketamine treatment. Methodology: A prospective longitudinal study of a small cohort (N = 35) of patients with heterogenous chronic refractory pain conditions was conducted from one week to two months follow-up. Results: pain Severity was significantly improved from mean 6.5 to 5.1 (t = 3.77, p pain Interference from mean 7.0 to 5.1 (t = 4.99, p pain Self-Efficacy Questionnaire (PSEQ) from mean 17 to 24 (t = 𕒷.37, p = 0.002, d = 𕒴.6) at 1-week and 23 (t =𕒶.60, p = 0.016, d =𕒴.5) at 2-month;pain Catastrophizing (PCS) from 28 to 23 (t = 3.4, p = 0.002;d = 0.6) at 1-week and 21 (t = 2.45, p = 0.022, d = 0.5) at 2-month;Depression from mean 21 to 16 (t = 2.16, p = 0.038, d = 0.4) at 1-week and 16 (t = 3.53, p = 0.002, d = 0.7) at 2-month;and oral Morphine Equivalent Daily Dose (oMEDD) reduced from mean 191 mg/day on admission to 122 mg/day at 1-week (t = 2.38, p = 0.023;d = 0.4) and 93 mg/day at 2-month (t = 2.59, p = 0.016;d = 0.5). There

关键词： chronic refractory pain Ketamine Infusion chronic refractory pain treat-ment Ketamine Therapy Pharmacotherapy

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