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Integrated causal inference modeling uncovers novel causal factors and potential therapeutic targets of Qingjin Yiqi granules for chronic fatigue syndrome

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Acupuncture and Herbal Medicine 2024年第1期4卷 122-133页

作者： Junrong Li Xiaobing Zhai Jixing Liu Chi Kin Lam Weiyu Meng Yuefei Wang Shu Li Yapeng Wang Kefeng Li Faculty of Applied Sciences Macao Polytechnic UniversityMacao SARChina Center for Artificial Intelligence Driven Drug Discovery Faculty of Applied SciencesMacao Polytechnic UniversityMacao SARChina National Key Laboratory of Chinese Medicine Modernization Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine TianjinChina

Objective:chronic fatigue syndrome(CFS)is a prevalent symptom of post-coronavirus disease 2019(COVID-19)and is associated with unclear disease *** herbal medicine Qingjin Yiqi granules(QJYQ)constitute a clinically approved formula for treating post-COVID-19;however,its potential as a drug target for treating CFS remains largely *** study aimed to identify novel causal factors for CFS and elucidate the potential targets and pharmacological mechanisms of action of QJYQ in treating ***:This prospective cohort analysis included 4,212 adults aged≥65 years who were followed up for 7 years with 435 incident CFS *** modeling and multivariate logistic regression analysis were performed to identify the potential causal determinants of CFS.A proteome-wide,two-sample Mendelian randomization(MR)analysis was employed to explore the proteins associated with the identified causal factors of CFS,which may serve as potential drug ***,we performed a virtual screening analysis to assess the binding affinity between the bioactive compounds in QJYQ and CFS-associated ***:Among 4,212 participants(47.5%men)with a median age of 69 years(interquartile range:69–70 years)enrolled in 2004,435 developed CFS by *** graph analysis with multivariate logistic regression identified frequent cough(odds ratio:1.74,95%confidence interval[CI]:1.15–2.63)and insomnia(odds ratio:2.59,95%CI:1.77–3.79)as novel causal factors of ***-wide MR analysis revealed that the upregulation of endothelial cell-selective adhesion molecule(ESAM)was causally linked to both chronic cough(odds ratio:1.019,95%CI:1.012–1.026,P=2.75 e^(−05))and insomnia(odds ratio:1.015,95%CI:1.008–1.022,P=4.40 e^(−08))in *** major bioactive compounds of QJYQ,ginsenoside Rb2(docking score:−6.03)and RG4(docking score:−6.15),bound to ESAM with high affinity based on virtual ***:Our integrated analytical framework combining epidemiological,genet

关键词： Causal factors Causal graph analysis chronic fatigue syndrome Drug targets Mendelian randomization Qingjin Yiqi

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Acupuncture for chronic fatigue syndrome:An Overview of Systematic Reviews

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Chinese Journal of Integrative Medicine 2021年第12期27卷 940-946页

作者： YIN Zi-han WANG Lin-jia CHENG Ying CHEN Jiao HONG Xiao-juan ZHAO Ling LIANG Fan-rong School of Acu-Mox and Tuina Chengdu University of Traditional Chinese MedicineChengdu(610075)China Acupuncture Clinical Research Center Chengdu University of Traditional Chinese MedicineChengdu(610075)China

Objective To evaluate the quality of the existing studies and summarize evidence of important outcomes of meta-analyses/systematic reviews(MAs/SRs)of *** Potentially eligible studies were searched in the following electronic databases from inception to 1 September,2019:Chinese Biomedical Literature Database(CBM),China Science and Technology Journal Database(VIP),China National Knowledge Infrastructure(CNKI),WanFang Database(WF),Web of Science,Embase,PubMed and Cochrane *** of Recommendation,Assessment,Development,and Evaluation(GRADE)was used to evaluate the quality of *** methodological quality of the literature was evaluated by A Measure Tool to Assess Systematic Reviews-2(AMSTAR-2)and the quality of the report was assessed by Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA).The intra-class correlation coefficient was used to assess the consistency of the reviewers,with an overall intraclass correlation coefficient score of *** Ten MAs/SRs were *** overall conclusions were that acupuncture had good safety and efficacy in the treatment of CFS,but some of these results were *** GRADE indicated that out of the 17 outcomes,high-quality evidence was provided in 0(0%),moderate in 3(17.65%),low in 10(58.82%),and very low in 4(23.53%).The results of AMSTAR-2 showed that the methodological quality of all included studies was critically *** PRISMA statement revealed that 8 articles(80%)were in line with 20 of the 27-item checklist,and 2 articles(20%)matched with 10-19 of the 27 *** We found that acupuncture on treating CFS has the advantage for efficacy and safety,but the quality of SRs/MAs of acupuncture for CFS need to be improved.

关键词： chronic fatigue syndrome acupuncture overview AMSTAR-2 GRADE PRISMA

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Effects of Exercise on Behavior and Peripheral Blood Lymphocyte Apoptosis in a Rat Model of chronic fatigue syndrome

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第2期30卷 258-264页

作者：邹军苑建齐吕爽屠嘉衡 Shanghai University of Sports Scientific Research Department Shanghai University of Sports College of Exercise & Sports Science

This study examined the effects of exercise on behavior and peripheral blood leukocyte apoptosis in a rat model of chronic fatigue syndrome （CFS）. Thirty-six healthy male Sprague-Dawley rats were equally randomized into 3 groups： the control group, CFS model group and the exercise group in terms of body weight. A total of 25 rats entered the final statistical analysis due to 11 deaths during the study. CFS model was established by subjecting the rats in CFS model group and exercise group to electric shock, chronic restraint stress and cold water swim. Besides, rats in the exercise group took rtmning wheel exercise. After a week of conditioning feeding, model construction and running wheel exercise were performed simultaneously, and lasted for 23 consecutive days. The behavior experiments, including running wheel exercise, open-field test, tail suspension test and Morris water maze test, were conducted, either before or after the model establishment. Rats were sacrificed and peripheral blood was obtained for the assessment of lymphocyte apoptosis index by flow cytometry （FCM）. It was found that as compared with those in the control group, the weight of the rats was decreased obviously （P〈0.01）, the mobility time in the open-field and the tail suspension tests was shortened significantly （P〈0.01）, the time to locate the platform was enhanced （P〈0.01） and the cell apoptosis index was increased substantially （P〈0.01） in the CSF model group. Meanwhile, in comparison to the model group, the behavior in the open-field and the tail suspension tests was improved significantly （P〈0.05）, and the apoptosis index decreased remarkably （P〈0.01） in the exercise group. It is concluded that sport intervention can prevent lymphocyte apoptosis and improve animal behavior rather than the memory.

关键词： running-wheel exercise chronic fatigue syndrome animal behavior lymphocyte apoptosis

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Clinical Study on Electroacupuncture plus Interferential Current Therapy for chronic fatigue syndrome

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Journal of Acupuncture and Tuina Science 2014年第3期12卷 156-159页

作者： Huang Fang Chen Xiong Zhou Li-zhi Huang Ping Guo Li-hong Hong Jue Department of Acupuncture and Moxibustion Taihe HospitalHubei University of Medicine Hubei University of Chinese Medicine

Objective: To observe the clinical efficacy of electroacupuncture plus interferential current therapy(ICT) in treating chronic fatigue syndrome(CFS), and to explore the mechanism. Methods: Sixty eligible CFS patients were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture plus ICT, while the control group was by electroacupuncture alone. The therapeutic efficacies were evaluated after 2 treatment courses and compared between the two groups. Results: The recovery rate and total effective rate were respectively 43.3% and 93.3% in the treatment group, versus 20.0% and 80.0% in the control group. There were significant differences in comparing the recovery rate and total effective rate between the two groups(P<0.05), showing that the recovery rate and total effective rate in the treatment group were higher than those in the control group. Conclusion: Electroacupuncture plus ICT can produce a remarkable efficacy in treating CFS.

关键词： Acupuncture Therapy Electroacupuncture Interferential Current Therapy chronic fatigue syndrome

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Effects of Electro-acupuncture on Hypothalamic-PituitaryAdrenal Index and Corticotropin Releasing Hormone mRNA Expression of Rats with chronic fatigue syndrome

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Journal of Acupuncture and Tuina Science 2007年第4期5卷 200-204页

作者：陈云飞杨文佳符胜光张晓丹 Yueyang Integrative Medicine Hospital Shanghai University of TCM Shanghai 200437 E R. China Shanghai University of TCM Shanghai 201203 E R. China Department of TCM Tongren Hospital Shanghai 200050 E R. China

Objective： To investigate the mechanism of electroacupuncturein treating chronic fatigue syndrome（CFS） in term of the neuro-endocrine system by observing the regulative effect of EA on hypothalamic-pituitary-adrenal index （HPA index） and corticotropin releasing hormone mRNA （CRH mRNA） in CFS model rats. Methods： The rats were randomly divided into control group, model group, and electroacupuncture group. Model and electroacupuncture groups were forced to swim in cold water to make CFS model, while rats in electroacupuncture group were treated with electroacupuncture treatment at the same time. Electroacupuncture group was given at Baihui（GV 20） and Zusanli（ST 36）. Evaluation of the model was processed according to the behavior changes of the rats. Hypothalamic, pituitary, and adrenal were weighted to calculate HPA index. CRH mRNA in hypothalamic was measured by fluorescence quantitative polymerase chain reaction （FQPCR）. Results： The model rats had behavior changes, and both physical and mental fatigue was observed. HPA index raised and expression of CRH mRNA in hypothalamus increased in CFS rats. After electroacupuncture treatment, the physical and mental fatigue was improved, and the hypothalamic index and CRH mRNA decreased significantly, while the pituitary and adrenal index only had little decrease. Conclusion： Cold water swim press could mimic the pathogenesis and make similar manifestations in rats with the common clinical symptoms. CFS has close relationship with increase of HPA index and CRH mRNA expression. Electroacupuncture can regulate the function of HPA axis to deal with CFS.

关键词： Electroacupuncture chronic fatigue syndrome Hypothalamic-Pituitary-Adrenal Index CRH Rats

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A Comparative Study of Antifatigue Effects of Taurine and Vitamin C on chronic fatigue syndrome

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Pharmacology & Pharmacy 2022年第8期13卷 300-312页

作者： Shin-Hee Kim Hyun-Jin Kim Semi Kim Ju-Seop Kang Young Tae Koo Sang Hun Lee Dong-Hyun Paik Medicine Park Co. Ltd. Seoul Republic of Korea Department of Pharmacology College of Medicine Hanyang University Seoul Republic of Korea Kwang-Dong Pharmaceutical Co. Ltd. Seoul Republic of Korea

Vitamin C and taurine (TR) are well known as active components for fatigue recovery. However, the mechanism of the anti-fatigue effects of vitamin C and TR is still unclear. Our study was designed to evaluate the anti-fatigue activities of vitamin C and TR in an animal test for fatigue and to compare the activities between vitamin C and TR. Materials and Methods: Vitamin C, TR or their combination were orally administrated to mice once daily for 15 days, and then metabolic activities such as blood glucose, triglyceride (TG), lactate, and lactate dehydrogenase (LDH) as well as antioxidant activities such as malondialdehyde (MDA) and superoxide dismutase (SOD) were determined (evaluated) after forced swimming test (FST). Results: Compared with the control group, C100, C200, and T50 showed a tendency to decrease mobility in FST. Moreover, TG (C100, C200, T200), LDH (C200), lactic acid (C100) and MDA (C50, C100, C200) levels were inhibited by vitamin C and TR. Conclusions: These results suggest that vitamin C and TR have anti-fatigue activities in mice, with vitamin C providing a stronger effect.

关键词： Vitamin C Taurine chronic fatigue syndrome Anti-fatigue Effect

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Observation on therapeutic efficacy of tuina plus cupping for chronic fatigue syndrome

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Journal of Acupuncture and Tuina Science 2020年第1期18卷 53-58页

作者： Wu Shuang Liu Lin-lin Wu Jiang-yun Guangxi School of Chinese Medicine Nanning 530000China Guangxi University of Chinese Medicine Nanning 530000China 不详

Objective:To observe the therapeutic efficacy of tuina plus cupping on chronic fatigue syndrome(CFS).Methods:A total of 100 CFS patients meeting the inclusion criteria were randomly divided into a treatment group and a control group according to the random number table in the sequence of visit,with 50 patients in each *** treatment group was treated with tuina plus cupping therapy,3 times a *** control group was given oral tablets of wild American ginseng *** 3 months of treatment,the score of fatigue questionnaire scale(FS-14)was observed and the efficacy was ***:The total effective rate was 92.0%in the treatment group,versus 76.0%in the control group and the difference between the two groups was statistically significant(Pfatigue symptoms significantly.

关键词： Tuina Massage Cupping Therapy chronic fatigue syndrome

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Acupuncture on back-shu points of five zang for chronic fatigue syndrome:A randomized control trial

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World Journal of Acupuncture-Moxibustion 2018年第4期28卷 237-241,309-310页

作者： San-san CHEN Ran LIU Bin WU Sheng CHEN Fang GUO Xiao-lin XUE Jun WANG Acupuncture Department Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Chinese Medicine Department People’s HospitalBeijing UniversityBeijing 100044China Beijing University of Chinese Medicine Beijing 100029China

Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after ***: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(Pfatigue scores, and mental fatigue scores were significantly reduced than before treatment(all Pfatigue scores were significantly reduced(both Pfatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the S

关键词： chronic fatigue syndrome Back-shu points of five zang Acupuncture thrapy Randomized control trial

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Accurate diagnosis of myalgic encephalomyelitis and chronic fatigue syndrome based upon objective test methods for characteristic symptoms

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World Journal of Methodology 2015年第2期5卷 68-87页

作者： Frank NM Twisk ME-de-pati?nten Foundation 1906 HB LimmenThe Netherlands

Although myalgic encephalomyelitis(ME) and chronic fatigue syndrome(CFS) are considered to be synonymous,the definitional criteria for ME and CFS define two distinct,partially overlapping,clinical ***,whether defined by the original criteria or by the recently proposed criteria,is not equivalent to CFS,let alone a severe variant of incapacitating chronic *** features of ME are:muscle weaknessand easy muscle fatigability,cognitive impairment,circulatory deficits,a marked variability of the symptoms in presence and severity,but above all,post-exertional "malaise":a(delayed) prolonged aggravation of symptoms after a minor *** contrast,CFS is primarily defined by(unexplained) chronic fatigue,which should be accompanied by four out of a list of 8 symptoms,e.g.,*** to the subjective nature of several symptoms of ME and CFS,researchers and clinicians have questioned the physiological origin of these symptoms and qualified ME and CFS as functional somatic ***,various characteristic symptoms,e.g.,post-exertional "malaise" and muscle weakness,can be assessed objectively using wellaccepted methods,e.g.,cardiopulmonary exercise tests and cognitive *** objective measures acquired by these methods should be used to accurately diagnose patients,to evaluate the severity and impact of the illness objectively and to assess the positive and negative effects of proposed therapies impartially.

关键词： Myalgic encephalomyelitis chronic fatigue syndrome Symptoms Diagnosis Disability Impact

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Posttreatment Lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome:A systematic review and comparison of pathogenesis

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慢性疾病与转化医学:英文版 2023年第3期9卷 183-190页

作者： Natalie A.Bai Christie S.Richardson Department of Psychiatry Rowan‐Virtua School of Osteopathic MedicineMount LaurelNew JerseyUSA

Lyme disease is the most common vector-borne illness in the United States and has been causing significant morbidity since its discovery in *** is well-documented that about 10%of patients properly treated with antibiotics never fully recover,but instead go on to develop a chronic illness dubbed,posttreatment Lyme disease syndrome(PTLDS)characterized by severe fatigue,cognitive slowing,chronic pain,and sleep *** review includes 18 studies that detail the symptoms of patients with PTLDS and uses qualitative analysis to compare them to myalgic encephalitis/chronic fatigue syndrome(ME/CFS),a strikingly similar *** the majority of the PTLDS studies,at least four of the six major symptoms of ME/CFS were also noted,including substantial impairment in activity level and fatigue for more than 6 months,post-exertional malaise,and unrefreshing *** one of the included PTLDS articles,26 of the 29 ME/CFS symptoms were *** study adds to the expanding literature on the post-active phase of infection syndromes,which suggests that chronic illnesses such as PTLDS and ME/CFS have similar pathogenesis despite different infectious origins.

关键词： chronic fatigue syndrome Lyme disease myalgic encephalitis posttreatment Lyme disease syndrome systematic review

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