检索结果-南通市图书馆

Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation

World Journal of Clinical Cases 2024年第6期12卷 1094-1103页

作者： Jing-Yi Zhu Mu-Yun Liu Chang Sun Department of Gastroenterology The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Gastroenterology Navy No.905 HospitalNaval Medical UniversityShanghai 200433China

BACKGROUND Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance(IR).However,the link between two of the most prevalent bowel disorders,chronic diarrhea and constipation,and the triglyceride glucose(TyG)index,a marker of IR,has not yet been *** To investigate the potential association between TyG and the incidence of chronic diarrhea and *** This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from *** was used as an exposure variable,with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables.A demographic investigation based on TyG quartile subgroups was *** application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG,chronic diarrhea,and *** analyses were performed to examine the stability of any potential *** In the chosen sample,chronic diarrhea had a prevalence of 8.00%,while chronic constipation had a prevalence of 8.04%.In multiple logistic regression,a more prominent positive association was found between TyG and chronic diarrhea,particularly in model 1(OR=1.45;95%CI:1.17-1.79,P=0.0007)and model 2(OR=1.40;95%CI:1.12-1.76,P=0.0033).No definite association was observed between the TyG levels and chronic *** weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63(OR=1.89;95%CI:1.05-3.41,P=0.0344),and another positive association with chronic constipation when it was greater than 8.2(OR=1.74;95%CI:1.02-2.95,P=0.0415).The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of *** Higher TyG levels were positively associated with abnormal bowel health.

关键词： Triglyceride glucose index National Health and Nutrition Examination Survey chronic diarrhea chronic constipation Cross-sectional study Bowel health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chronic constipation:Facilitator factor for development of varicocele

引用

World Journal of Gastroenterology 2011年第21期17卷 2641-2645页

作者： Guldem Kilciler Ahmet Ali Sancaktutar Ali Avcl Mete Kilciler Engin Kaya Murat Dayanc Department of Gastroenterology Gulhane Military Medical Academy Department of Urology Gulhane Military Medical Academy

AIM:To evaluate the possible relationship between varicocele and chronic ***:Between April 2009 and May 2010,a total of 135 patients with varicocele or constipation and 120 healthy controls were *** were divided into two *** both groups detailed medical history was taken and all patients were examined physically by the same urologist and *** of them were evaluated by color Doppler *** patients with constipation,except for the healthy controls of the second group,underwent a colonoscopy to identify the etiology of the *** the first group,we determined the rate of chronic constipation in patients with varicocele and in the second group,the rate of varicocele in patients with chronic *** both groups,the rate of the disease was compared with age-matched healthy *** the second group,the results of colonoscopies in the patients with chronic constipations were also ***:In the first group,mean age of the study and control groups were 22.9 ± 4.47 and 21.8 ± 7.21 years,respectively(P chronic constipation was observed in 8 of the 69 patients with varicocele(11.6%) and 3 out of 60 in healthy controls(5%),*** this regard,there was no statistical significance between varicocele patients and the healthy control(P = 0.37).In the second group,varicocele was observed in 16 of the 66 patients with chronic constipation(24.24%) and 12 out of 60 in healthy controls(20%) ***,there was no statistical significance between chronic constipation and healthy controls(P = 0.72).Internal/external hemorrhoids were detected in 4 of the 16 patients with chronic constipation and varicocele,in the second *** the remaining 50 patients with chronic constipation 9 had internal/external *** this

关键词： Varicocele chronic constipation Hemorrhoid Intra-abdominal pressure Relationship

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A randomized,double-blind,placebo-controlled trial assessing the efficacy and safety of tegaserod in patients from China with chronic constipation

引用

World Journal of Gastroenterology 2007年第5期13卷 732-739页

作者： San-Ren Lin Mei-Yun Ke Jin-Yan Luo Yao-Zong Yuan Ji-Yao Wang Shelley diTommaso Verena Walter Jiaqing Huang The 3rd Hospital Beijing Medical University Beijing China Peking Union Medical College Hospital BeijingChina The 2nd Hospital of Xian Jiaotong University Shanxi China Shanghai Ruijin Hospital Shanghai China Shanghai Zhongshan Hospital Shanghai China Novartis Pharma AG Basel Switzerland Novartis Pharmaceuticals Corp East HanoverNew Jersey United States

AIM： To evaluate the efficacy and safety of tegaserod, 6 mg twice daily （b.i.d.）, in men and women with chronic constipation （CC） from China. METHODS： This was a multicenter, double-blind, placebo-controlled study. Following a 2-wk treatmentfree baseline period, patients were randomized to receive either tegaserod （6 mg b.i.d.） or placebo （b.i.d.） for 4 wk. An analysis of covariance with repeated measures was used to determine the overall effect of treatment for the primary efficacy variable; the change from baseline in the number of complete spontaneous bowel movements （CSBMs） during the 4-wk treatment period. Secondary efficacy endpoints included other measures of response in terms of CSBMs, and patients＇ daily and weekly assessment of bowel habits. Safety was also assessed, based on the incidence and severity of adverse events （AEs）. RESULTS： A total of 607 patients were randomized to receive either tegaserod （n = 304） or placebo （n = 303）. Tegaserod treatment resulted in a rapid and significant increase from baseline in the adjusted mean number of CSBMs per week over wk 1-4 compared with placebo （1.39 vs 0.91, P = 0.0002）. A statistically significant difference in favor of tegaserod was also observed for a mean increase ≥ 1 CSBM/wk over wk 1-4 （47.7% vs 35.0%, tegaserod vs placebo, respectively, P = 0.0018） and for the absolute number of≥ 3 CSBMs/wk over wk 1-4 （25.0% vs 14.5%, tegaserod vs placebo, respectively, P = 0.0021）. Improvements in other symptoms of CC were also seen in the tegaserod group, including improved stool form and reduced straining. In addition, more patients in the tegaserod group reported satisfactory relief from their constipation symptoms. The frequency and severity of AEs was comparable between tegaserod and placebo groups, with the exception of a greater incidence of diarrhea in patients receiving tegaserod （3.6%） compared with placebo （1.7%）. CONCLUSION： Tecjaserod treatment improved multiple symptoms of CC and was associated with a fa

关键词： chronic constipation tegaserod China Complete spontaneous bowel movement Placebocontrolled Stool

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current developments in pharmacological therapeutics for chronic constipation

引用

Acta Pharmaceutica Sinica B 2015年第4期5卷 300-309页

作者： Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease China Pharmaceutical University

chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-EF1'1 receptor modulators velusetrag and naronapride, the guanylate cy-clase C agonist plecanatide and die deal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/by-ne-rid/4.0/).

关键词： chronic constipation Prokinetic agent 5-HT1 receptor Prosecretory agent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential oxidative stress in children with chronic constipation

引用

World Journal of Gastroenterology 2005年第3期11卷 368-371页

作者： Jun-FuZhou Jian-GuoLou Sheng-LiZhou Ji-YueWang SecondHospital CollegeofMedicineZhejiangUniversityHangzhou310009ZhejiangProvinceChina Children'sHospital CollegeofMedicineZhejiangUniversityHangzhou310003ZhejiangProvinceChina

AIM: To investigate the potential oxidative stress in children with -chronic constipation and to explore its ***: Seventy children with chronic constipation and 70 age- and sex-matched healthy children were enrolled in a randomized controlled study. Plasma levels of vitamins C and E, activities of superoxide dismutase and catalase and lipoperoxide level in erythrocytes were determined by ***: Compared with healthy children whose vitamin C,vitamin E, superoxide dismutase, catalase and lipoperoxide were 58.35±14.42 μmol/L, 27.15±6.55 μmol/L, 2 206±171U/(g· Hb), 327.3±82.2 K/(g·Hb) and 19.18±4.27 nmol/(g·Hb)respectively, the levels of vitamin C, vitamin E, the activity of superoxide dismutase, and catalase in the children with chronic constipation significantly decreased [46.59±11.51 μmol/L,20.65±4.80 μmol/L, 1943±147 U/(g·Hb) and 269.3±67.8 K/(g·Hb),respectively P＜0.01], while the lipoperoxide significantly increased [25.22±5.01 nmol/(g·Hb), P＜0.01]. With a prolonged course of disease, the levels of vitamin C, vitamin E, the activity of superoxide dismutase and catalase in the children with chronic constipation gradually decreased,while the level of lipoperoxide gradually ***: chronic constipation can cause potential oxidative stress in children.

关键词： chronic constipation Potential oxidative stress Spectrophotometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Value of a Modified Colonic Transit Test in the Diagnosis of chronic constipation

引用

Journal of Nutritional Oncology 2022年第3期7卷 153-160页

作者： Yu Ji Chen Bin Zhao Yi Qun Liao Chen Wei Yi Chao Ma Fei Wang Dao Rong Wang Dong Tang Department of General Surgery Clinical Medical CollegeYangzhou UniversityYangzhou 225001JiangsuChina Department of General Surgery The Yangzhou School of Clinical Medicine of Dalian Medical UniversityDalian 116044LiaoningChina Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou UniversityNorthern Jiangsu People's HospitalYangzhou 225001JiangsuChina

Objectives To explore the value of performing a modified colonic transit test in the diagnosis of chronic *** we retrospectively analyzed the results in 101 patients admitted to the MDT Outpatient Clinic of Subei People’s Hospital,Jiangsu Province,China,from July 1,2019,to July 31,*** were prohibited from using drugs and stimulant foods that could affect bowel motility for three days before and during the *** performed two abdominal X-rays at 6 and 72 hours after oral ingestion of the barium suspension to observe the residual condition of barium in the patient's *** then gave specific treatments based on the different types of constipation detected in the *** Compared with patients with normal transit,patients with slow transit(Pconstipation,but also shows the colon morphology,providing a reference for possible subsequent treatments.

关键词： chronic constipation Colonic transit test Radiopaque markers Barium suspension Abdominal plain film

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence and Clinical Characteristics of chronic constipation in Senegalese Children

引用

Open Journal of Pediatrics 2023年第6期13卷 921-928页

作者： Abou Ba Aliou Thiongane Ndeye Fatou Sow Babacar Niang Younoussa Keïta Fatou Ly Ousmane N’diaye Service de pédiatrie centre hospitalier national Dalal Jamm Dakar Senegal Centre hospitalier national d’enfants Albert Royer Dakar Senegal Service de pédiatrie centre hospitalier Abass Ndao Dakar Senegal Service de pédiatrie centre hospitalier national de Pikine Dakar Senegal

Introduction: constipation is the infrequent emission of hard stools. It is common, most often of functional origin, with a prevalence ranging from 0.7% to 29.6%. The aim of our study was to investigate the prevalence of constipation in children undergoing paediatric gastroenterology. Methodology: This was a bi-centric retrospective study carried out at the Albert Royer Children’s Hospital and the Dalal Jamm Hospital Pediatrics Department. Children followed in the pediatric gastroenterology consultation during the period from January 1, 2013 to February 29, 2020 were included. Results: A total of 337 children (205 boys;60.83%) were included, representing a prevalence of 25%. The median age was 3 years 6 months. The 13 - 24 months age group was the most frequent (27.6%). Rare stools were the main reason for consultation (92.8%). Rare stools were noted in 92.88% of cases. Bristol types 1 and 2 accounted for 6.53% and 54.60% respectively. The main associated signs were abdominal pain (29.4%), followed by abdominal bloating (20.96%). Abdominal pain was functional in 73.58% of cases. Under treatment, 90.19% of children had a favorable outcome. Conclusion: constipation is common in Senegalese children with a prevalence close to that reported in Western countries. In most case, it is functional with good prognostic.

关键词： Children chronic constipation Bristol Scale Dakar Hirschsprung Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The level of 25-hydroxyvitamin D is associated with depressive symptoms in the chronic constipation of elderly patients

The level of 25-hydroxyvitamin D is associated with depressi...

引用

2020长三角老年医学高峰论坛、浙江省老年医学学术大会、华东老年医学中心联盟会议、浙江省老年医学联盟会议、浙江省老年病专科联盟会议

作者：黄毕林丁西平胡世莲

Purpose:constipation is a common functional gastrointestinal disorder in the elderly *** decreased level of 25-hydroxyvitamin D may be a candidate risk factor of depressive symptoms in the chronic constipation of elderly patients which need to be screened for *** aim of this study was to investigate the relationship between the level of 25-hydroxyvitamin D and the depressive symptoms in the chronic constipation of elderly *** and methods:Patients aged 60 years or above who was diagnosed as chronic constipation were enrolled from the The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China from January 2017 to September *** symptoms（Geriatric Depression Scale ≥ 6） were assessed by the Geriatric Depression Scale（GDS）.The 25-hydroxyvitaminD [25（OH）D] were detected in all the ***'s t-test or chi-squared test was used to compare the data between participants with and without chronic *** regression models were performed to explore the relationship between the lever of 25-hydroxyvitamin D and the depressive symptoms in the chronic constipation of elderly ***:A total of 126 patients aged 60-97 years（median age 78 years） including 74 chronic constipation and 52 without chronic constipation were *** was no statistical difference in baseline data such as age,gender,and chronic diseases between the patients with and without chronic *** proportion of the depression symptoms was 68% in the chronic constipation participants and 12% in the non-chronic constipation participants（χ=28.3,P=0.00）.There was a significant difference in the score of GDS between the patients with or without chronic constipation（18.3±4.4 VS 7.6±2.5,t=13.4,p=0.00）.Also,there was a significant difference in the lever of level of 25-hydroxyvitamin D between the he patients with or without chronic constipation（10.9 ± 3.5 VS 29.3 ± 6.

关键词： Depression symptoms 25-hydroxyvitaminD chronic constipation elderly

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Comparative efficacy of eight drugs for chronic constipation:quantitative information for medication guidelines

Comparative efficacy of eight drugs for chronic constipation...

引用

2018年中国药理学会定量药理学专业委员会学术年会

作者： Yi Zhang Fang Yin Ling Xu Yunfei Li Junchao Chen Hongxia Liu Qingshan Zheng Lujin Li Center for Drug of Clinical Research Shanghai University of Traditional Chinese Medicine

Background:chronic constipation is a common gastrointestinal dysfunction ***,people generally lack the awareness of diagnosis and treatment of chronic constipation,resulting in delays in the course of chronic ***,the drugs to treat constipation are mainly divided into osmotic laxatives,stimulant laxatives,chloride channel activators,guanylate cyclase C agonists,serotonin 5-hydroxytryptamine 4(5-HT) receptor agonists,ileal bile acid transporter inhibitors,***,the relevant quantitative information is scarce in the current constipation medication guidelines,and they do not clearly reflect the differences in the characteristics of therapeutic efficacy among various ***:In this study,we aimed to establish a pharmacodynamic model to quantitatively describe the time course of each drug used for chronic constipation in order to identify relevant impacting factors and to use pharmacodynamic parameters to directly reflect the characteristics of the therapeutic efficacy of each drug,especially the rebound ***:A comprehensive literature survey was conducted in the public databases,and search keywords included indications and drug *** randomized placebo controlled trials were included in the *** frequency of change from the baseline of spontaneous bowel movement(SBM) and complete spontaneous bowel movement(CSBM) was used as efficacy *** eliminate the effect of dietary and lifestyle heterogeneity on the therapeutic drug efficacy,we established models based on the difference in efficacy between a drug group and the corresponding placebo group(namely,‘true’ drug efficacy) to describe the time course of SBM and CSBM for each drug.#12 E is the observed efficacy at the time point j in the 1 drug group.E represents the theoretical maximal efficacy of the i drug group.τ is the rate of rebound in the i drug group;ε is the residual error in the i drug group at the time point j, and was weighted by t

关键词： chronic constipation efficacy rebound model-based meta analysis

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Reoperation in an adult female with "right-sided" Hirschsprung's disease complicated by refractory hypertension and cough

引用

World Journal of Gastroenterology 2016年第41期22卷 9235-9241页

作者： Zhi-Jian Wei Lei Huang A-Man Xu Department of Gastrointestinal Surgery The First Affiliated Hospital of Anhui Medical University Hefei 230022 Anhui Province China German Cancer Research Center 69120 Heidelberg Germany Department of General Surgery The Fourth Affiliated Hospital of Anhui Medical University Hefei 230000 Anhui Province China

Hirschsprung's disease(HD) is an intestinal malformation caused by the innate absence of ganglion cells in the neural plexus of the colorectal wall, and is most common in male infants. It is rare in adult, and is usually left-sided. Herein we reported based on the CARE guidelines a case of a 47-year-old adult female suffering from "right-sided" HD complicated by refractory hypertension and cough. The patient with a history of cesarean section and with digestive unfitness(abdominal pain, distention, and constipation) only since 20 years old had recurrence of HD after initial surgery due to the incomplete removal of the HD-affected bowel based on a diagnosis of "chronic ileus", leading to the relapse of the digestive symptoms and the emergence of some intractable circulatory and respiratory complications which could be hardly controlled by conservative treatment. During the long interval before coming to our department for help, she had been re-hospitalized for several times with various misdiagnoses and supplied merely with symptomatic treatment which could only achieve temporary symptomatic relief. At her admission to our department, the imaging examinations strongly indicated recurrent HD which was further supportedb y p a t h o l o g i c a l e x a m i n a t i o n s, a n d r i g h t h e m i-colectomy was performed to remove the remnant aganglionic intestinal segment. Intraoperative and postoperative pathology supported the completeness of the definitive resection. Post-operation, the patient's bowel motility significantly improved, and interestingly, the complications disappeared. For adult patients with long-term constipation combined with cough and hypertension, rare diseases like HD which requires definite surgery and which could be "right-sided" should not be overlooked. It is vital to diagnose and cure HD patients in childhood. Through the comparison of the two surgeries, it is noteworthy that for diagnosed HD, sufficient removal of the non-functional intestin

关键词： Adult Hirschsprung’s disease Reoperation Ileus chronic constipation Hypertension Cough CARE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：