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Procalcitonin in inflammatory bowel disease: Drawbacks and opportunities

World Journal of Gastroenterology 2017年第47期23卷 8283-8290页

作者： Giuseppe Lippi Fabian sanchis-Gomar section of Clinical Biochemistry University of Verona Leon H. Charney Division of Cardiology New York University School of Medicine Department of Physiology Faculty of Medicine University of Valencia and INCLIVA Biomedical Research Institute

The measurement of procalcitonin has recently become a mainstay for the diagnosis and therapeutic management of severe bacterial infections, especially those sustained by Gram-negative bacteria. Therefore, the aim of this article is to provide a narrative overview on the potential role of procalcitonin measurement in patients with inflammatory bowel disease(IBD). According to the available scientific literature, the clinical significance of procalcitonin for diagnosing IBD or monitoring disease activity remains elusive, and its association with disease severity is confined to a limited number of case-control studies, with low sample size. Nevertheless, literature data also suggests that a supranormal procalcitonin serum concentration(i.e., > 0.5 ng/m L) may reflect the presence of a number of infective complications in IBD, especially bacterial enterocolitis, bacterial gastroenteritis, intraabdominal abscess, postsurgical infection and sepsis. Rather than for diagnosing or assessing disease activity, the measurement of this biomarker may hence retain practical clinical significance for early prediction, timely diagnosis and therapeutic monitoring of many IBDassociated infections and complications.

关键词： Intestinal bowel disease chron’s disease Ulcerative colitis Procalcitonin

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sudden cardiac death in a case of Crohn's disease with COVID-19: A case report

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Journal of Acute disease 2022年第3期11卷 123-126页

作者： Neeraj Kumar subhajit Ghosh Abhyuday Kumar sanjeev Kumar Prem Kumar Departments of Trauma&Emergency All India Institute of Medical SciencesPatnaIndia Departments of Anaesthesiology All India Institute of Medical SciencesPatnaIndia Departments of CTVs All India Institute of Medical SciencesPatnaIndia Departments of Radiology All India Institute of Medical SciencesPatnaIndia

Rationale:The mechanism of sudden cardiac death in COVID-19 can be *** hypersensitivity to 5-AsA therapy leading to myocarditis has been reported in some *** storm syndrome and idiosyncratic reaction with mesalazine use may lead to sudden cardiac death in *** of immunosuppressants in hospitalized COVID-19 patients should be continued with caution,especially in patients with inflammatory bowel ***’s concern:A 75-year-old man who was tested positive for sARs-CoV-2 was admitted with a history of shortness of breath for the last two *** was a known case of Crohn’s disease treated with ***:COVID-19 pneumonia with underlying Crohn’s disease leading to sudden cardiac ***:Remdesivir,antibiotics,steroids,low molecular weight heparin,tablet zinc,tab vitamin C,and other supportive treatment were *** of increased inflammatory markers,itolizumab was given to the patient on the 2nd ***:On the 5th day of the intensive care unit,the patient complained of sudden chest pain with respiratory distress leading to bradycardia and asystole and could not be ***:Causes for sudden cardiac death in COVID-19 pneumonia patients with Crohn’s disease is *** mesalazine may be a safe and effective drug in the management of inflammatory bowel disease,it can induce sytokine strom syndrome and idiosyncratic reactions that could be one of the reasons of sudden cardic ***,we should be aware of its serious and potentially life-threatening complications,especially in COVID-19 infected patients.

关键词： COVID-19 sudden cardiac death chron’s disease

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