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Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity

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World Journal of Gastroenterology 2006年第15期12卷 2437-2440页

作者： De-Sheng Weng Jin-Tian Li Shi-Juan Mai Zhi-Zhong Pan Bing-Jian Feng Qi-Sheng Feng Li-Xi Huang Qi-Jing Wang Yong-Qiang Li Xing-Juan Yu Shi-Ping Chen Jia He Jian-Chuan Xia Research Section of Oncopathology State Key Laboratory of Oncology in Southern china Cancer CenterZhongshan University Guangzhou 510064 Guangdong ProvinceChina

AIM： To define the common deleted region on the long arm of haman chromosome 7q linked to primary gastric carcinomas in Chinese by loss of heterozygosity （LOH） and its clinical significance. METHODS： Nine microsatellite markers distributed over chromosome 7q with an average marker density of 10cM were used to examine 70 primary gastric carcinomas for LOH by PCR amplification. The PCR products were separated by electrophoresis on polyacrylamide gel. Genescan and Genotyper softwares were used to analyze LOH. RESULTS： LOH with at least one marker on 7q occurred in 34.3% （12/50） of the tumors. Among them, LOH at D7S486 and D7S798 was higher in 24.0% （24/70） and 29.2% （5/26）, respectively. By statistical analysis we also observed an obvious genotype-phenotype correlation on 7q （P〈0.05）. The frequency of LOH at D7S486 in patients with lymph node metastasis was significantly higher than that in those without lymph node metastasis （P=0.015）. CONCLUSION： The high incidence of LOH at D7S486 and its correlation with poorer prognosis suggest that there might be putative tumor suppressor genes in this region involved in the tumorigenesis and progression of gastric carcinoma.

关键词： LOH chromosome 7 Gastric cancer

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Extracellular control of chromosomal instability and maintenance of intra-tumoral heterogeneity

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 468-482页

作者： Yi-Hong Zhou Kambiz Afrasiabi Mark E.Linskey UC Irvine Brain Tumor Laboratory in Department of Surgery University of CaliforniaIrvineIrvineCA 92697USA

Aim:Current cancer treatments are challenged by the plasticity of cancer cells,largely influenced by chromosomal instability(CIN)leading to variations in karyotype known as tumor-specific aneuploidy,which in turn,leads to intra-tumor cellular heterogeneity(TH).Cells with certain chromosomal defects often survive treatment and the growth-associated states of TH persist in recurrent *** of the CIN rate seems to reside within the tumor *** an attempt to develop a therapy targeting cancer plasticity,we studied the possible extracellular control of CIN rate in Chr7-defined TH in ***:Chr7-fluorescence in situ hybridization was applied on various grades of gliomas,in vitro cultures and intracranial xenografts of two syngeneic glioma lines(U251 and U251-NS)derived from various cell-inoculating densities,with or without EFEMP1 ***:A grade-dependent increase of trisomy-7 population and Chr7-defined cell diversity was shown in gliomas.A negative association between Chr7-MS rate and initial cell-inoculating density was observed which was prevented by EFEMP1 ***:Our data demonstrate that CIN is a major driver for cancer cell plasticity and suggest that CIN can be controlled by extracellular factors derived from normal and tumor cells,and EFEMP1 is one of these factors.

关键词： Malignant glioma intra-tumoral heterogeneity functional tumor subpopulations chromosome 7 chromosome

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Relationship Between Gene-Phenotype and Clinical Manifestations of Chromosomal Copy Number Variations Indicated by Non-Invasive Prenatal Testing

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Journal of Clinical and Nursing Research 2024年第1期8卷 88-95页

作者： Zixin Pi Xiaoyan Duan Jing Peng Yanhui Liu The First People’s Hospital of Jiangxia District Wuhan City(Union Jiangnan Hospital Huazhong University of Science and Technology)Wuhan 430200Hubei ProvinceChina Department of Reproductive Medicine Luohu HospitalShenzhenShenzhen 518005Guangdong ProvinceChina

Objective:To analyze the clinical value of non-invasive prenatal testing(NIPT)in detecting chromosomal copy number variations(CNVs)and to explore the relationship between gene expression and clinical manifestations of chromosomal copy number ***:3551 naturally conceived singleton pregnant women who underwent NIPT were included in this *** NIPT revealed abnormalities other than sex chromosome abnormalities and trisomy 13,18,and *** women with chromosome copy number variations underwent genetic counseling and prenatal ultrasound *** prenatal diagnosis and chromosome microarray analysis(CMA)were *** clinical phenotypes and pregnancy outcomes of different prenatal diagnoses were ***,a follow-up was conducted by telephone to track fetal development after birth,at six months,and one year ***:A total of 53 cases among 3551 cases showed chromosomal copy number *** prenatal diagnosis was performed in 36 cases:27 cases were negative and 8 were consistent with the NIPT test *** indicates that NIPT’s positive predictive value(PPV)in CNVs is 22.22%.Conclusion:NIPT has certain clinical significance in screening chromosome copy number variations and is expected to become a routine screening for chromosomal microdeletions and ***,further interventional prenatal diagnosis is still needed to identify fetal CNVs.

关键词： Non-invasive prenatal testing Chromosomal copy number variation chromosomes 1 and 3 chromosome 4 chromosome 7 chromosome 15 Prenatal diagnosis

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