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Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology

World Journal of Gastroenterology 2012年第2期18卷 150-155页

作者： Dimitrios Tsapralis Ioannis Panayiotides George Peros Theodore Liakakos Eva Karamitopoulou 3rd Department of Surgery Attikon University HospitalUniversity of AthensRimini 112464 AthensGreece 2nd Department of Pathology University of AthensRimini 112464 AthensGreece 4th Department of Surgery Attikon University HospitalUniversity of AthensRimini 112464 AthensGreece Department of Pathology Aretaieion University HospitalUniversity of AthensVass.Sophias 7611528 AthensGreece

AIM:To assess human epidermal growth factor receptor-2 (HER2)-status in gastric cancer and matched lymph node metastases by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH).METHODS:120 cases of primary gastric carcinomas and 45 matched lymph node metastases from patients with full clinicopathological features were mounted onto multiple-punch and single-punch tissue microarrays,respectively,and examined for HER2 overexpression and gene amplification by IHC and ***:Twenty-four tumors (20%) expressed HER2 *** IHC score of ≥ 2+ was observed in 20 tumors (16.6%).HER2 amplification was detected by CISH in 19 tumors (15.8%) and in their matched lymph node metastases.A high concordancerate was found between HER2 positivity (as detected by IHC) and HER2 gene amplification (as detected by CISH),since 19 of the 20 IHC positive cases were amplified (95%).All amplified cases had 2+ or 3+ IHC *** was associated with intestinal phenotype (P tion with grading,staging or survival was ***:In gastric cancer,HER2 amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases.

关键词： Human epidermal growth factor receptor-2 Immunohistochemistry chromogenic in situ hybridiza-tion Gastric cancer

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