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国际心血管病杂志 1985年第3期 172-173页

作者：陈万春

美国国立心、肺、血液研究所(National Heart,Lung and Blood Institute——NHLBI)对Ⅱ型高血脂症患者进行了研究;观察消胆胺和饮食控制对冠状动脉硬化进展和血脂的影响。143例冠状动脉疾病(CAD)患者(有心肌梗塞病史,心绞痛,运动试验阳... 详细信息

美国国立心、肺、血液研究所(National Heart,Lung and Blood Institute——NHLBI)对Ⅱ型高血脂症患者进行了研究;观察消胆胺和饮食控制对冠状动脉硬化进展和血脂的影响。143例冠状动脉疾病(CAD)患者(有心肌梗塞病史,心绞痛,运动试验阳性,或胸透示冠状动脉钙化),经过低胆固醇、低脂饮食后,其血浆低密度脂蛋白-胆固醇(LDL-C)仍高者,被列为观察对象。凡左下降支主干狭窄75%以上,或冠状动脉管腔狭窄不到20%者均被剔除。消胆胺的剂量为每天24克。试验采用药物和安慰剂

关键词：冠状动脉消胆胺胆固醇酰胺 cholestyramine HDL 胆甾醇胆固醇 LDL 血浆脂类血脂

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消胆胺[除胆树脂(cholestyramine)]治疗顽固性腹泻

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陕西医学杂志 1975年第3期 61-61页

作者：史鹏飞

消胆胺是一种不溶解的四价铵阴离子交换树脂,能结合胆酸及内毒素。病人及结果7例持久性严重腹泻10～25天的儿童,用口服消胆胺治疗2～6天。婴儿年龄2～24周。2例肠部分切除术后做回肠造口术。均未证实腹泻原因。曾注射氨苄青霉素或青霉... 详细信息

消胆胺是一种不溶解的四价铵阴离子交换树脂,能结合胆酸及内毒素。病人及结果7例持久性严重腹泻10～25天的儿童,用口服消胆胺治疗2～6天。婴儿年龄2～24周。2例肠部分切除术后做回肠造口术。均未证实腹泻原因。曾注射氨苄青霉素或青霉素及卡那霉素,静脉补液,口服电解质液及蛋白水解产物或大豆食物治疗无效。消胆胺疗法限于每天大便10次或更多,持续7天以上者。每天口服消胆胺4～8克,最多6天。1～2天内腹泻减少,停药后无复发。腹泻停止后给予简单食

关键词：治疗后粘膜损伤消胆胺胆固醇酰胺 cholestyramine

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消胆胺〔除胆树脂(cholestyramine)〕治疗顽固性腹泻

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广东医药资料 1975年第6期 52-52页

作者：史鹏飞

消胆胺是一种不溶解的四价铵阴离子交换树脂,能结合胆酸及内毒素。一、疗效观察严重持久性腹泻10～25天的儿童共7例,用口服消胆胺治疗2～6天。婴儿年龄2～24周。2例肠部分切除术后做回肠造口术。均未证实腹泻原因。曾注射氨苄青霉素或... 详细信息

消胆胺是一种不溶解的四价铵阴离子交换树脂,能结合胆酸及内毒素。一、疗效观察严重持久性腹泻10～25天的儿童共7例,用口服消胆胺治疗2～6天。婴儿年龄2～24周。2例肠部分切除术后做回肠造口术。均未证实腹泻原因。曾注射氨苄青霉素或青霉素及卡那霉素、静脉补液、口服电解质液及蛋白水解产物或大豆食物治疗无效。消胆胺疗法限于每天大便10次或更多、持续7天以上者。每天口服消胆胺4～8克,最多6天。腹泻于l～2天内减少,停药后无复发。腹泻停止后给予简单食物,均耐受极好。1例发生便秘,停药后消失。

关键词：消胆胺 cholestyramine 顽固性腹泻回肠造口术静脉补液腹泻原因四价蛋白水解切除术持久性

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Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion

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World Journal of Gastroenterology 2004年第10期10卷 1440-1446页

作者： N.Sertac Kip Konstantinos N.Lazaridis Anatoliy I.Masyuk Patrick L.Splinter Robert C.Huebert Nicholas F.LaRusso Center for Basic Research in Digestive Diseases Division of Gastroenterology and HepatologyDepartment of Internal MedicineMayo Medical SchoolClinic and FoundationRochesterMN 55905USA

AIM: We have previously demonstrated that cholangiocytes, the epithelial cells lining intrahepatic bile ducts,encode two functional bile acid transporters via alternative splicing of a single gene to facilitate bile acid vectorial transport. Cholangiocytes possess ASBT,an apical sodium-dependent bile acid transporter to take up bile acids,and t-ASBT,a basolateral alternatively spliced and truncated form of ASBT to efflux bile *** hepatocyte and ileal bile acid transporters are in part regulated by the flux of bile acids, the effect of alterations in bile acid flux on the expression of t-ASBT in terminal ileocytes remains ***,we tested the hypothesis that expression of ASBT and t-ASBT in cholangiocytes and ileocytes was regulated by bile acid flux. METHODS: Expression of ASBT and t-ASBT message and protein in cholangiocytes and ileocytes isolated from pair- fed rats given control (C) and 1% taurocholate (TCA) or 5% cholestyramine (CY) enriched diets,were assessed by both quantitative RNase protection assays and quantitative *** data obtained from each of the control groups were pooled to reflect the changes observed following TCA and CY treatments with respect to the control diets. Cholangiocyte taurocholate uptake was determined using a novel microperfusion technique on intrahepatic bile duct units (IBDUs) derived from C,TCA and CY fed rats. RESULTS: In cholangiocytes,both ASBT and t-ASBT message RNA and protein were significantly decreased in response to TCA feeding compared to C *** contrast, message and protein of both bile acid transporters significantly increased following CY feeding compared to C *** the ileum,TCA feeding significantly up-regulated both ASBT and t-ASBT message and protein compared to C diet,while CY feeding significantly down-regulated message and protein of both bile acid transporters compared to C *** anticipated from alterations in cholangiocyte ASBT expression,the uptake of taurocholate in microp

关键词： cholestyramine dosage Ileum Taurocholic Acid Alternative Splicing Animals Bile Ducts Diet Eating Epithelial Cells Gene Expression Regulation Male Organic Anion Transporters, Sodium-Dependent Protein Isoforms Rats Rats, Inbred F344 Symporters

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Effects of High-Fat Diets Containing Different Fats on Cholesterol Metabolism in Starvation-Refeeding Rats

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Food and Nutrition Sciences 2011年第6期2卷 647-654页

作者： Reiko Inai Tatsuhiro Matsuo Faculty of Agriculture Kagawa University (2393 Ikenobe Miki-cho Kita-gun Kagawa 761-0795 JAPAN).

The present study was performed to investegate the effects of high-fat diets containing different fats on cholesterol metabolism in starvation-refeeding rats. Forty female Donryu rats were divided into two groups and then fed high-fat diets containing beef tallow or corn oil without cholesterol for 14 days. Then, 10 rats from each group were divided into high-cholesterol and cholesterol-free groups (Experiment 1). Another 10 rats from beef tallow and corn oil groups were divided into high-cholesterol and high-cholesterol-cholestyramine groups (Experiment 2). All rats were fasted for 2 days followed by 3 days of feeding. In Experiment 1, the high-cholesterol diet caused significant increases in plasma total cholesterol and cholesteryl ester concentrations in the beef tallow diet group. In Experiment 2, dietary cholestyramine markedly decreased plasma and liver cholesterol levels;however, these cholesterol levels were higher in the beef tallow diet group even if cholestyramine was added to the diet. These results suggested that the cholesterol- lowering effect of dietary corn oil may not be due solely to reabsorption of bile acids. This study suggested that high-fat diets containing different fats affected cholesterol metabolism under conditions of starvation-refeeding.

关键词： Starvation-Refeeding Cholesterol Metabolism Beef Tallow Corn Oil cholestyramine

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