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A Case of Severe cholestatic hepatitis Induced by a Novel Dual Agonist of Glucagon-like Peptide-1 and Glucosedependent Insulinotropic Polypeptide Receptors

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Journal of Clinical and Translational Hepatology 2024年第11期12卷 949-954页

作者： Junmin Jiang Meifeng Shi Shuduo Wu Minling Cao Department of Hepatology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdongChina

Glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic polypeptide(GIP)receptor agonists are increasingly used in the management of type 2 diabetes mellitus and obesity due to their ability to stimulate insulin secretion,delay gastric emptying,and suppress *** combination of GLP-1 and GIP agonists improves glycemic control and promotes weight ***,the introduction of these novel therapies has raised safety concerns,including the risk of cholestatic *** report a case of a patient with obesity who was prescribed a GLP-1/GIP dual-receptor agonist as part of his treatment ***,both before the initiation of this therapy and during the course of treatment,the patient was not taking any other *** after receiving four doses of the therapy,the patient developed symptoms of severe cholestatic hepatitis,including jaundice and elevated liver enzyme *** hospitalization,no alternative causes for the condition were identified,and a liver biopsy confirmed the diagnosis of druginduced cholestatic *** is the first recorded case of cholestatic hepatitis induced by a GLP-1/GIP dual agonist,and it aimed to raise global awareness of this potential side effect.

关键词： GLP-1 receptor GIP receptor cholestatic hepatitis Obesity

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Network pharmacology assessment of Qingkailing injection(清开灵注射液)treatment of cholestatic hepatitis

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Journal of Traditional Chinese Medicine 2021年第1期41卷 167-180页

作者： LIAN Yajun WANG Qingguo MU Jie LIU Haixia XU Tian FAN Shuning TANG Feifei FENG Tianyi XU Wenxiu JIN Na CHENG Fafeng WANG Xueqian The Basic Research of Classic Recipe Application Innovation Research Group College of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To investigate the targets and mechanisms of action of Qingkailing injection(清开灵注射液,QKL)in the treatment of cholestatic ***:A network pharmacology method was implemented using drug and disease databases to target QKL and cholestasis hepatitis,*** functional protein association network STRING database was used to construct a protein-protein interaction network using R language and the Bioconductor *** *** and cluster Profiler packages were used for gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis,which explored biological functions and pathways of potential *** were then visualized using Cytoscape 3.6.0 ***:We screened 121 compounds in QKL and identified 112 targets for the treatment of cholestatic *** played a role in the treatment of cholestatic hepatitis through 305 biology process terms,15 cellular component and 29 molecular function *** mechanism of QKL action was mainly related to tumor necrosis factor,mitogen-activated protein kinase,and PI3 K-Akt signaling ***:The treatment of cholestatic hepatitis by QKL involved multiple targets,biological functions,and signaling pathways that are closely associated with the disease.

关键词： cholestatic hepatitis protein interaction maps pharmacology Qingkailing injection

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Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation

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World Journal of Gastroenterology 2009年第31期15卷 3937-3939页

作者： Ihab I El Hajj Shahid M Malik Hany R Alwakeel Obaid S Shaikh Eizaburo Sasatomi Hossam M Kandil Department of Internal Medicine Division of GastroenterologyHepatology and NutritionUniversity of Pittsburgh Medical Center Department of Pathology University of Pittsburgh

Selective cyclooxygenase-2 （COX-2） inhibitors are widely used due to their efficacy and good safety profile. However, recent case reports have described varying degrees of liver injudes associated with the use of COX-2 inhibitors. We report the case of a patient who developed acute cholestatic hepatitis progressing to hepatic failure requiring liver transplantation, following a 3-d course of celecoxib for treatment of generalized muscle aches and pains. The clinical presentation, the laboratory data, as well as the liver histopathology were supportive of the putative diagnosis of drug induced liver injury.

关键词： Celecoxib cholestatic hepatitis Liver failure Liver transplantation

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Effects of ursodeoxycholic acid on intrahepatic cholestasis in rats

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Chinese Medical Journal 2003年第7期116卷 1099-1103页

作者：李兰娟徐小微吕芳芳赵年丰 Department of Infectious disease First Affiliated Hospital College of Medicine of Zhejiang University Department

Objective To investigate the effects of treatment with ursodeoxycholic acid (UDCA) on intrahepatic cholestasis in rats, and to explore its mechanism Method Rats suffering from intrahepatic cholestasis were treated with UDCA Their serum alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), γ glutamyl transpeptidase (γ GT), total cholesterol (TCH), bile flow, total bile acid excretion, total Na + and TCH of bile were measured before and after treatment In addition, the changes of liver tissue under microscrope were observed and recorded Results Compared with the control group, serum ALT, ALP, TBIL, DBIL, γ GT and TCH of rats in the treatment group decreased, while bile flow, total bile acid excretion, total Na + and TCH decreased significantly Degeneration of hepatocytes, infiltration of inflamed cells and proliferation of small bile ducts in the treatment group were improved under microscope ####Conclusion UDCA may have therapeutic effects on cholestatic hepatitis The mechanism may involve in its hydrophilicity, choleretic effect and immune modulation

关键词： ursodeoxycholic acid cholestatic hepatitis immunomodulation

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