检索结果-南通市图书馆

An Efficient One-pot Synthesis of Certain Stereoselective Spiro[pyrazole-4,5′-isoxazoline]-5-one Derivatives:In vitro Evaluation of Antitumor Activities,Molecular Docking and In silico ADME Predictions

引用

Chemical Research in Chinese Universities 2022年第4期38卷 1073-1082页

作者： Ghadah F.ALJOHANI Fatma A.A.EL-HAG Mohamed S.BEKHEIT Ewies F.EWIES May A.EL-MANAWATY Chemistry Department College of ScienceTaibah UniversityP.O.Box 30002Code 14177Al-Madinah Al MunawarahSaudi Arabia Department of Chemistry of Natural and Microbial Products National Research CentreDokkiP.O.Box 12622GizaEgypt Pesticide Chemistry Department National Research CentreDokkiP.O.Box 12622GizaEgypt Organometallic and Organometalloid Chemistry Department National Research CentreDokkiP.O.Box 12622GizaEgypt Department of Pharmacognosy National Research CentreDokkiP.O.Box 12622GizaEgypt

Alibrary of novel spiro[pyrazole-4,5′-isoxazoline]-5-one derivatives were designed and synthesized using a concise and efficient one-pot reaction protocol through 1,3-dipolar cycloaddition between 4-benzylidene-3-methyl-1-phenyl-^(1)H-pyrazol-5(4H)-one and *** synthesized derivatives were elucidated and characterized based on their spectroscopic data,including infrared spectrometry(IR),^(1)H NMR,^(13)C NMR,and elemental and mass spectral *** synthesized compounds were evaluated for their antitumor inhibition potency against four human cancer cell lines,including human prostatic adenocarcinoma(PC3),human colorectal carcinoma(HCT116),human liver hepatocellular carcinoma(HepG2)and breast adenocarcinoma(MCF7).The outcomes were compared with the standard reference drug *** the synthesized chlorooximes,compounds 6d and 6e were the most active compounds on all cell *** spiro[pyrazole-4,5′-isoxazoline]-5-one derivatives 7a and 7c were active on the HepG2 liver cancer cell *** comparison,compounds 7f and 7g were moderately active on the MCF7 cell *** structure-activity relationship was explored for the synthesized ***,in silico analysis of physicochemical,adsorption,distribution,metabolism,excretion and toxicity(ADMET)properties were done to determine the potential capacity of drug *** docking study onto the epidermal growth factor(EGF)tyrosine kinase receptor(3POZ)was done for the most active compounds to validate the reliability of in vitro anticancer screenings.

关键词： Spiroisoxazoline Pyrazole chlrooxime 1,3-Dipolar cycloaddition Antitumor Molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：