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Electrodeposition of chitosan/graphene oxide conduit to enhance peripheral nerve regeneration

Neural Regeneration Research 2023年第1期18卷 207-212页

作者： Ya-Nan Zhao Ping Wu Zi-Yuan Zhao Fei-Xiang Chen Ao Xiao Zhi-Yi Yue Xin-Wei Han Yong Zheng Yun Chen Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Clinical Medical College Hubei University of Science and TechnologyXianningHubei ProvinceChina

Currently available commercial nerve guidance conduits have been applied in the repair of peripheral nerve defects.However,a conduit exhibiting good biocompatibility remains to be developed.In this work,a series of chitosan/graphene oxide(GO)films with concentrations of GO varying from 0-1 wt%(collectively referred to as CHGF-n)were prepared by an electrodeposition technique.The effects of CHGF-n on proliferation and adhesion abilities of Schwann cells were evaluated.The results showed that Schwann cells exhibited elongated spindle shapes and upregulated expression of nerve regeneration-related factors such as Krox20(a key myelination factor),Zeb2(essential for Schwann cell differentiation,myelination,and nerve repair),and transforming growth factorβ(a cytokine with regenerative functions).In addition,a nerve guidance conduit with a GO content of 0.25%(CHGFC-0.25)was implanted to repair a 10-mm sciatic nerve defect in rats.The results indicated improvements in sciatic functional index,electrophysiology,and sciatic nerve and gastrocnemius muscle histology compared with the CHGFC-0 group,and similar outcomes to the autograft group.In conclusion,we provide a candidate method for the repair of peripheral nerve defects using free-standing chitosan/GO nerve conduits produced by electrodeposition.

关键词： chitosan electrodeposition free-standing graphene oxide nerve conduit nerve factors Schwann cells tissue engineerin

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A robust polyacrylic acid/chitosan cryogel for rapid hemostasis

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Science China(Technological Sciences) 2022年第5期65卷 1029-1042页

作者： SHI MingYue JIANG LiJie YU ChaoJie DONG XiaoRu YU QingYu YAO MengMeng HE ShaoShuai YUE ZhiWei YAO FangLian ZHANG Hong SUN Hong LI JunJie School of Chemical Engineering and Technology Tianjin UniversityTianjin300350China School of Basic Medical Sciences North China University of Science and TechnologyTangshan063210China Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering Ministry of EducationTianjin UniversityTianjin300350China

Currently,it is a challenge to develop hemostatic materials with high water absorption capacity and anti-fatigue properties for quickly preventing massive hemorrhage from arteries and visceral organs.A series of polyacrylic acid/chitosan(PAA/CS)cryogels were prepared by a cryostructurization technique to improve mechanical performance and hemostatic efficiency of chitosan(CS).In this system,the chemically cross-linked PAA network was used as a framework to improve water absorption behaviors and mechanical strength.The CS network was co-blended by hydrogen bonding and electrostatic interactions,both of which synergistically promoted hemostasis.These cryogels had high porosity(>94%),rapid water absorption rate(2000%),outstanding mechanical strength,and fatigue resistance.Moreover,the results of cytotoxicity and hemolysis demonstrated that the cryogels had good biocompatibility.Notably,the PAA/CS cryogels exhibited superior whole blood coagulation ability and red blood cell and platelet adhesion ability compared to those of commercial hemostatic dressing(gauze,gelatin sponges,and CS sponges).Based on these results,mouse femoral artery hemorrhage models and liver hemorrhage models were prepared to investigate the hemostatic ability of the prepared PAA/CS cryogels.Results suggested that the hemostatic ability of PAA5/CS cryogels was superior to that of commercial hemostatic materials.Therefore,the PAA/CS cryogels showed potential application in preventing massive hemorrhage from arteries and visceral organs.

关键词： hemostatic dressing chitosan polyacrylic acid cryogel

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Bio-inspired, bio-degradable adenosine 5′ -diphosphate-modified hyaluronic acid coordinated hydrophobic undecanal-modified chitosan for hemostasis and wound healing

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Bioactive Materials 2022年第11期7卷 162-177页

作者： Yihao Liu Haoyi Niu Chengwei Wang Xiaoxiao Yang Wentao Li Yuxin Zhang Xiaojun Ma Yuanjing Xu Pengfei Zheng Jinwu Wang Kerong Dai Shanghai Key Laboratory of Orthopedic Implant Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RdShanghai200011China Department of Orthopaedic Surgery Children’s Hospital of Nanjing Medical UniversityNo.72 Guangzhou RdNanjing210008China Department of Rehabilitation Huashan HospitalFudan UniversityNo.12 Middle Urumqi RdShanghai200040China Med-X Research Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityNo.1956 Huashan RdShanghai200030China Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineNo.85 Wujin RdShanghai200080China

Uncontrolled hemorrhage and wound infection are crucial causes of trauma-associated death in both the military and the clinic. Therefore, developing an efficient and rapid hemostatic method with biocompatibility, easy degradation, and wound healing is of great importance and desirability. Inspired by spontaneous blood cell plug formation in the hemostasis process, an adenosine 5′-diphosphate modified pro-coagulation hyaluronic acid (HA-ADP) coordinated with enhanced antibacterial activity of undecanal-modified chitosan (UCS) was fabricated through physical electrostatic cross-linking and freeze-drying. The as-prepared hydrogel sponges showed a porous structure suitable for blood cell adhesion. In particular, the hydrogel exhibited excellent antibacterial ability and promoted the adhesion of platelets and red blood cells, thus inducing a prominent pro-coagulation ability via platelet activation, which exhibits a shorter hemostasis time (58.94% of control) in vitro. Compared with commercially available CELOX and gelatin sponge (GS), HA-ADP/UCS accelerates hemostasis and reduces blood loss in both rat tail amputation and rat artery injury models. Furthermore, all the samples exhibited su-perior cytocompatibility and biodegradability. Due to these performances, HA-ADP/UCS promoted full-thickness skin defect healing significantly in vivo. All the properties of HA-ADP/UCS suggest that it has great potential for translation as a clinical application material for hemostatic and wound healing.

关键词： Hemostasis Antibacterial Wound healing Hyaluronic acid chitosan

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Preparation and properties of chitosan-VC loaded nano-silver-doped natural latex

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Progress in Natural Science:Materials International 2022年第5期32卷 625-633页

作者： Liangzhi Jia Liqiao Wei Yanhong Zhang Hua Wang Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education College of Materials Science and Engineering Taiyuan University of Technology China Development Strategy Institute for Building Materials Industry College of Textile Engineering Taiyuan University of Technology

As one kind of the modern medical devices, various catheters are commonly used in interventional therapy, but they are prone to infection in the human body, which is a defect in clinical treatment. At present, the commonly used catheters are mostly treated with antibacterial coatings on the rubber catheters. However, there are some problems for their application, such as, easy peeling of the coating and poor durability of antibacterial properties.In order to solve the above problems, a kind of nano-silver antibacterial agent reduced and stabilized by Vitamin C modified chitosan was prepared, and then added into natural latex to produce an antibacterial latex with antibacterial properties from the inside to the outside. The chemical properties, mechanical properties and antibacterial properties of the samples were characterized, and the antibacterial mechanism of VC modified chitosan/nano silver was analyzed. The results showed that the antibacterial rates of the latex samples against E. coli and S. aureus reached 97.38% and 98.45%.

关键词： chitosan Nano silver Antibacterial Natural latex

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Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-basedmulti-material hydrogel composites

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Bio-Design and Manufacturing 2023年第2期6卷 150-173页

作者： Suihong Liu Haiguang Zhang Tilman Ahlfeld David Kilian Yakui Liu Michael Gelinsky Qingxi Hu Centre for Translational Bone Joint and Soft Tissue ResearchFaculty of Medicine and University Hospital Carl Gustav CarusTechnische Universität Dresden01307 DresdenGermany Rapid Manufacturing Engineering Center School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444China Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444China National Demonstration Center for Experimental Engineering Training Education Shanghai UniversityShanghai 200444China

Three-dimensional printing technologies exhibit tremendous potential in the advancing fields of tissue engineering and regenerative medicine due to the precise spatial control over depositing the biomaterial.Despite their widespread utilization and numerous advantages,the development of suitable novel biomaterials for extrusion-based 3D printing of scaffolds that support cell attachment,proliferation,and vascularization remains a challenge.Multi-material composite hydrogels present incredible potential in this field.Thus,in this work,a multi-material composite hydrogel with a promising formulation of chitosan/gelatin functionalized with egg white was developed,which provides good printability and shape fidelity.In addition,a series of comparative analyses of different crosslinking agents and processes based on tripolyphosphate(TPP),genipin(GP),and glutaraldehyde(GTA)were investigated and compared to select the ideal crosslinking strategy to enhance the physicochemical and biological properties of the fabricated scaffolds.All of the results indicate that the composite hydrogel and the resulting scaffolds utilizing TPP crosslinking have great potential in tissue engineering,especially for supporting neo-vessel growth into the scaffold and promoting angiogenesis within engineered tissues.

关键词： Multi-material composite hydrogel Crosslinking mechanism chitosan Gelatin Egg white 3D printing

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Preparation of chitosan and citric acid crosslinked membrane and its application in quasi-solid supercapacitors

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Rare Metals 2023年第2期42卷 430-437页

作者： Hao-Hang Xu Liang Yue Yang Tang Fan Liu Hong-Jiu Zhu Shu-Juan Bao Institute for Clean Energy&Advanced Materials School of Materials and EnergySouthwest UniversityChongqing400715China

Quasi-solid electrolytes promote the development of safe and flexible energy storage devices.In this work,a chitosan and citric acid crosslinked membrane is prepared by a freeze-thaw cross-linking method,in which the chemical crosslinking of chitosan and citric acid increase the viscoelastic behavior of the polymer membrane,and the freeze-thaw assist freeze drying process to create abundant interconnected open-pores and three-dimensional(3D)network.Due to the good viscoelasticity,excellent electrolyte loading capacity(596%)and high ion conductivity(7.7×10^(-3)S·cm^(-)1),as quasi-solid electrolyte,our proposed chitosan and citric acid crosslinked membrane helps ZnICCFT-ZnSO4lAC hybrid supercapacitor to delivers wide operating voltage,high specific capacity of 100.5 F·g^(-1)and stable cycle life(93%after1000 cycles),which suggests that our proposed freezethaw assisted freeze drying method has great potential in designing quasi-solid state electrolyte for energy storage device.

关键词： Quasi-solid electrolyte chitosan Freeze-thaw Hybrid supercapacitor

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3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro

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Journal of Materials Science & Technology 2023年第11期142卷 34-44页

作者： Jiazhao Yang Fan Liu Changshun Zhou Hejie Li Gaolin Yang Shiyuan Fang In-Seop Lee Yi Liu Hao Bai Cen Chen The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Orthodontics School of StomatologyChina Medical UniversityShenyang 110002China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Institute of Laser Advanced Manufacturing Zhejiang University of TechnologyHangzhou 310023China Institute of Human Materials Suwon 16514Republic of Korea State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine Hangzhou 310018China

The modification of 3D printed porous titanium(Ti),especially for the internal pore structure,is critical and has received more attention to promoting its osteogenesis for clinical use.Ultra-violet(UV)responsive chitosan(CSMA),as an injectable filling material,was firstly incorporated into porous Ti,and then CSMA was in-situ mineralized by carbon oxide(CO_(2))diffusion(CSMA/CaCO_(3)).Their physical-chemical and biological properties were investigated in vitro.CaCO_(3) crystals within CSMA hydrogels were successfully deposited into pores of porous Ti,which exhibited favorable biocompatibility.Ti implants filled with CSMA/CaCO_(3) promoted adhesion and proliferation of bone mesenchymal stem cells(BMSCs).Moreover,Ti implant filled CSMA/CaCO_(3) hydrogels could increase alkaline phosphatase(ALP)activities,up-regulate osteopontin(OPN)and osteocalcin(OCN)expression levels,and enhance extracellular mineralization.3D printed porous Ti filled with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs,and have great potential for the modification of porous Ti implants in bone tissue engineering.

关键词： Porous titanium chitosan Ultraviolet(UV)-responsive Mineralization Osteogenesis

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Preparation and Performance of chitosan/Citric Acid Modified Magnesium Oxychloride Cement

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Journal of Wuhan University of Technology(Materials Science) 2023年第6期38卷 1326-1334页

作者： SONG Zijian LIU Lang YU Peipei ZHANG Yunsheng LI Xincheng CHU Hongqiang JIANG Linhua College of Mechanics and Materials Hohai UniversityNanjing 2100China School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Yunnan Institute of Building Research Co. LtdKunming 650223China

Citric acid(CA)and chitosan(CS)were employed to modify magnesium oxychloride cement(MOC).Multiscale measurements were implemented to study the properties of the modified MOC pastes.Results show that the addition of CA/CS significantly changes the content of each phase and the microstructure of phase 5.The single addition of CA can effectively increase the compressive strength of MOC after 7 d curing,while CS exerts no obvious effect on the compressive strength.As to the simultaneous addition of CA and CS,the compressive strength of MOC gradually decreases with the increasing content of CS.Interestingly,mixing CA and CS significantly enhances the water resistance of MOC and decreases the degradation rate of MOC in phosphate buffered solution,which can be ascribed to the low specific surface area of the plate-like crystals in the modified MOC and the reduction of pores in the structure.

关键词： magnesium oxychloride cement modifier citric acid chitosan

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A novel gene-activated matrix composed of PEI/plasmid-BMP2 complexes and hydroxyapatite/chitosan-microspheres promotes bone regeneration

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Nano Research 2022年第7期15卷 6348-6360页

作者： Ruyuan Ding Yajun Liu Dawei Cheng Gang Yang Wenjing Wu Haoran Du Xin Jin Yihan Chen Yuanyin Wang Boon Chin HENG Qing Yang Jianguang XU Key Lab.of Oral Diseases Research of Anhui Province College&Hospital of StomatologyAnhui Medical UniversityHefei 230032China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China School of Medical and Life Sciences Sunway UniversitySelangor Darul EhsanMalaysia Department of Orthopaedics The First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China Department of Chemistry and Laboratory of Nanomaterials for Energy Conversion(LNEC)University of Science and Technology of China(USTC)Hefei 230026China

The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area within the field of bone tissue engineering and regenerative medicine.However,growth factors directly incorporated in protein form are easily degraded,and have a limited active half-life,which cannot exert long-term and stable osteoinductive and oteoconductive effects.The combination of gene therapy and tissue engineering through gene-activated matrix(GAM)may provide a good alternative solution to overcome such limitations.Scaffold materials can be combined together with plasmid DNA and a chemical-based transfection agent to form GAM,through which transfected cells could secrete growth factors in a sustained manner over a longer time duration;thereby enabling bone graft materials to act as a repository of therapeutic genes,while providing structural support and a scaffold matrix for new bone tissue ingrowth.In this study,we prepared hydroxyapatite/chitosan-microspheres(HA/CS-MS)with microfabrication technology and emulsification method,and loaded the polyethylene imine/bone morphogenetic protein 2 plasmid(PEI/pBMP2)complexes with high transfection capacity(transfection efficiency up to 54.79%±4.95%),thus forming a novel GAM system with superior bone regeneration capacity—PEI/pBMP2-HA/CS-MS.The in vitro experiments in this study demonstrated that our GAM had excellent biocompatibility(with cell viability over 95%),and that the as-fabricated microsphere material possessed a nano-network fibrous structure similar to natural extracellular matrix(ECM),together with a higher surface area that can provide more cell adhesion sites.The sizes of the prepared microspheres were mainly distributed in the 160–180μm range,while the maximal loading rate of PEI-pBMP2 complexes was 59.79%±1.85%.As a loaded complexes system,the GAM can release plasmids in a slow controlled manner,effectively transfecting surrounding target cells(release effect for up to 21 days),while cells adherent to the material can al

关键词： BMP2 chitosan gene therapy nanoparticle regeneration microsphere

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Flexible and disposable paper-based gas sensor using reduced graphene oxide/chitosan composite

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Journal of Materials Science & Technology 2022年第6期101卷 165-172页

作者： Hyunjun Park Woong Kim Sang Won Lee Joohyung Park Gyudo Lee Dae Sung Yoon Wonseok Lee Jinsung Park Department of Control and Instrumentation Engineering Korea UniversitySejong 30019Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Biotechnology and Bioinformatics Korea UniversitySejong 30019Republic of Korea Department of Electrical Engineering Korea National University of TransportationChungju 27469Republic of Korea

Nitrogen dioxide(NO_(2))is a representative toxicant in air pollution that mostly arises from the exhaust gas released by automobiles.It is related to various respiratory diseases such as pneumonia and sudden infant death syndrome.Additionally,because the toxicity of nitrogen dioxide is high in overpopulated areas(i.e.,a capital or metropolis),the development of simple,practical,and facile sensors is highly needed.This work presents a flexible and disposable paper-based NO_(2)sensor based on a reduced graphene oxide/chitosan(r GO/CS)composite.The synthesized r GO/CS composite can be easily flexed and deformed into various shapes,which are attributed to chitosan molecules that function as a dispersion and reduction agent and support material.In addition,this composite can be attached to paper owing to its adhesive property;hence it can be utilized in versatile applications in a disposable manner.By analyzing the conductive change of the r GO/CS composite when it reacts with NO_(2),we can detect nitrogen dioxide in a concentration range of 0–100 ppm with a detection limit of 1 ppm.Moreover,we performed NO_(2)detection in the exhaust gas released by automobiles using the r GO/CS composite for practical application.The results indicated that the r GO/CS composite has the potential to be used in feasible gas sensing as a facile and disposable sensor under various conditions.

关键词： Reduced graphene oxide chitosan Composite material Nitrogen dioxide Paper-based gas sensor Flexible and disposable sensor

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