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Asian Journal of Andrology 2020年第6期22卷 616-622页

作者： Zhi Cao Jin Ji Fu-Bo Wang Chen Kong Huan Xu Ya-Long Xu Xi Chen Yong-Wei Yu Ying-Hao Sun Department of Urology Changhai HospitalNavy Medical UniversityShanghai 200433China Department of Traditional chinese Medicine NewJiangwan City Community Health Service CentreShanghai 200433China Department of Pathology Changhai HospitalNavy Medical UniversityShanghai 200433China

Membrane-associated guanylate kinase(MAGUK)family protein MAGUK invert 2(MAGI-2)has been demonstrated to be involved in the tumorigenic mechanism of prostate *** objective of this study was to investigate the expression of MAGI・2 at mRNA and protein *** prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate cancer was also *** expression data of MAGI・2 were assessed through database retrieval,analysis of sequencing data from our group,and tissue immunohistochemistry using digital scoring system(H・score).The clinical,pathological,and follow-up data were *** expression of MAGI-2 in prostate tumor tissues and prostate normal tissues was evaluated and ***-2 expression was associated with clinical parameters including tumor stage,lymph node status,Gleason score,PSA level,and biochemical recurrenee of prostate *** relative expression of MAGI-2 mRNA was lower in the tumor tissue in The Cancer Genome Atlas(TCGA)database and sequencing data(Ppatients with higher MAGI-2 expression had longer biochemical recurrence-free survival in the univariate analysis(P=0.005),which in dicates an optimal prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate can cer.I n con elusion,MAGI-2 expressi on gradually decreases with tumor progression,and can be used as a predictor of tumor recurrence in chinese patients.

关键词： biochemical recurrenee chinese patients MAGI-2 prostate cancer tissue microarray

Safety and efficacy of obinutuzumab in chinese patients with B-cell lymphomas: a secondary analysis of the GERSHWIN trial

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Cancer Communications 2018年第1期38卷 335-343页

作者： Yan Qin Yuqin Song Zhixiang Shen Xin Du Wei Ji Wanling Hsu Jun Zhu Yuankai Shi Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsNational Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Lymphoma Beijing Cancer HospitalPeking UniversityBeijing 100142P.R.China Department of Hematology Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025P.R.China Department of Hematology Guangdong General Hospital/Guangdong Academy of Medical SciencesGuangzhou 510030GuangdongP.R.China Clinical Science Shanghai Roche Pharmaceuticals LtdShanghai 201203P.R.China Statistics Roche(China)Holding LtdShanghai 201203P.R.China

Background:patients with relapsed/refractory B-cell lymphomas have limited treatment *** is an open-label,single-arm,phase Ib study of obinutuzumab monotherapy in chinese patients with histologically docu-mented CD20+relapsed/refractory chronic lymphocytic leukemia(CLL),diffuse large B-cell lymphoma(DLBCL),or follicular lymphoma(FL).The primary outcome measure of pharmacokinetics has been previously *** now present data on the secondary endpoint measures(e.g.,safety,and efficacy and pharmacodynamics).Methods:patients received 1000 mg obinutuzumab intravenously on days 1,8,and 15 of cycle 1(CLL patients;first dose split over 2 days),and on day 1 of cycles *** cycle lasted for 21 days;the treatment period was 24 *** subjects receiving at least one dose of obinutuzumab were included in the analysis of safety,efficacy,as well as ***:A total of 48 patients(>18 years of age)were enrolled(CLL:12;DLBCL:23;FL:13).The subjects received a median of two lines of anticancer treatment prior to the ***-five patients(72.9%)had at least one adverse event(AE).The most frequent AE was infusion-related reactions(15 patients;31.3%),followed by pyrexia(11 patients;22.9%).Treatment-related AEs were reported in 28 patients(58.3%),and included one death(interstitial lung disease).End-of-treatment(EoT)response rate was 33.3%.Best overall response rate was 47.9%.Most CLL patients achieved a partial response at EoT(58.3%).CD19+depletion occurred in 75.0%of the patients with CLL,and all patients with FL and ***:The safety and efficacy of obinutuzumab monotherapy in chinese patients with B-cell lymphomas were similar to that observed in previous studies in non-chinese patients;no new safety signals were observed.

关键词： Obinutuzumab B-cell lymphoma Chronic lymphocytic leukemia chinese patients

AWGS2019 vs EWGSOP2 for diagnosing sarcopenia to predict longterm prognosis in chinese patients with gastric cancer after radical gastrectomy

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World Journal of Clinical Cases 2021年第18期9卷 4668-4680页

作者： Wen-Yi Wu Jiao-Jiao Dong Xin-Ce Huang Zhe-Jing Chen Xiao-Lei Chen Qian-Tong Dong Yong-Yu Bai The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000Zhejiang ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Sarcopenia is a nutrition-related disease and has a profound effect on the longterm overall survival(OS)of patients with gastric *** diagnostic criterion is critical to clinical diagnosis and ***,previous research reported widely differing sarcopenia prevalence due to different ***2019 and EWGSOP2 are the two latest and widely adopted *** To compare the effects of AWGS2019 and EWGSOP2 on the long-term OS of chinese gastric cancer patient after radical *** An observational study was conducted from July 2014 to January 2017,which included 648 consecutive gastric cancer patients who underwent radical *** sarcopenia elements(skeletal muscle index,handgrip strength,and gait speed)were measured within 1 mo or 7 d before *** patients were followed at fixed intervals to gain the *** Cox regression analysis was performed to determine the association between sarcopenia and the long-term OS of these patients according to the two criteria *** predictive performance of the models with AWGS2019 and EWGSOP2 were evaluated by the concordance index(C-index)and area under the time-dependent receiver operating characteristic curve(AUC).The Akaike information criterion(AIC)was applied to compare model *** The prevalence of sarcopenia was 20.5%and 11.3%according to AWGS2019 and EWGSOP2,*** was an independent risk factor for the longterm OS no matter based on AWGS2019 or EWGSOP2,but AWGS2019-sarcopenia in multivariate model had a higher hazard ratio(HR)[2.150(1.547-2.988)]than EWGSOP2-sarcopenia[HR 1.599(1.092-2.339)].Meanwhile,the model with AWGS2019-sarcopenia[C-index 0.773(0.742-0.804);AIC 2193.7;time-dependent AUC 0.812(0.756-0.867)for 1-year OS,0.815(0.778-0.852)for 3-year OS,and 0.809(0.759-0.859)for 5-year OS]had better predictive power and model fits than the model with EWGSOP2-sarcopenia[C-index 0.762(0.729-0.795);AIC 2215.2;timedepende

关键词： Sarcopenia Gastric cancer EWGSOP2 AWGS2019 chinese patients

Identification of FECH gene multiple variations in two chinese patients with erythropoietic protoporphyria and a review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第10期17卷 813-820页

作者： Zhang-biao LONG Yong-wei WANG Chen YANG Gang LIU Ya-li DU Guang-jun NIE Yan-zhong CHANG Bing HAN Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Laboratory of Molecular Iron Metabolism College of Life ScienceHebei Normal University chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Erythropoietic protoporphyria（EPP）, an autosomal dominant disease, is caused by partial deficiency of ferrochelatase（FECH）, which catalyzes the terminal step of heme biosynthesis because of loss-of-function mutations in the FECH gene. To date, only a few cases have been described in Asia. In this study, we describe the clinical features of two chinese patients with EPP, with diagnosis confirmed by the increase of free protoporphyrin in erythrocytes, detection of plasma fluorescence peak at 630–634 nm, and analysis of FECH gene mutations. Using gene scanning, we identified a small deletion in the FECH gene（c.973 delA） in one proband（patient A） and a pathogenic FECH mutation（c.1232 GT） in the other（patient B） and also observed some nucleotide variations（c.798 CG, c.921 AG, IVS1-23 CT, IVS3＋23 AG, IVS9＋35 CT, and IVS3-48 TC） in these patients. The family pedigree of patient A was then established by characterization of the genotype of the patient＇s relatives. We also analyzed the potential perniciousness of the missense mutation with bioinformatic software, Polyphen and Sift. In summary, chinese EPP patients have similar manifestations to those of Caucasians, and identification of the chinese FECH gene mutations expands the FECH genotypic spectrum and may contribute to genetic counseling.

关键词： Erythropoietic protoporphyria chinese patients Clinical manifestation Ferrochelatase Missense mutations

Diabetes mellitus and hepatocellular carcinoma:Comparison of chinese patients with and without HBV-related cirrhosis

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World Journal of Gastroenterology 2010年第35期16卷 4467-4475页

作者： Chun Gao Hong-Chuan Zhao Jing-Tao Li Shu-Kun Yao Graduate School Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Department of Gastroenterology China-Japan Friendship Hospital Ministry of Health Beijing 100029China

AIM:To determine the role of diabetes mellitus(DM) and other associated factors in chinese hepatocellular carcinoma(HCC) patients with cirrhosis,compared with those HCC patients without cirrhosis,in the single setting of hepatitis B virus(HBV) infection,after other known concomitant diseases were ***:A total of 482 patients,treated at the China-Japan Friendship Hospital,Ministry of Health(Beijing,China),in the period January 2003 to June 2009,and with a hospital discharge diagnosis of HCC,were ***,clinical,laboratory,metabolic and instrumental features were ***:Of the total,310 patients were diagnosed with HBV infection and,following the inclusion and exclusion criteria,224 were analyzed,including 122 patients(54.5%) with cirrhosis(the case group) and 102 patients without cirrhosis(the control group).Twentyseven patients(12.1%) were diabetic,including 19 in the case group and 8 in the control group(19/122=15.6% vs 8/102=7.8%,P=0.077).Thirty-one possible relevant parameters were compared by univariate analysis,and 9 variables were selected for multivariable analysis,including DM(P=0.077),past history of HBV infection(P=0.005),total bilirubin(Ppatients with HBV-related cirrhosis,compar

关键词： Diabetes mellitus Hepatocellular carcinoma Hepatitis B virus Cirrhosis chinese patients

Organic anion transporting polypeptide-1B1 haplotypes in chinese patients

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Acta Pharmacologica Sinica 2007年第10期28卷 1693-1697页

作者： Lin-yong XU~2,Yi-jing HE~3,Wei ZHANG~3,Sheng Deng~4,Qing LI~3,Wei-xia ZHANG~3,Zhao-qian LIU~3,Dan WANG~3,Yuan-feiHUANG~3,Hong-hao ZHOU~(3,5),Zhen-qiu SUN~(2,5)~2 Department of Epidemic and Health Statistics,School of Public Health,Central South University,Changsha 410078,China,~3 Pharmaeoge-netics Research Institute,Institute of Clinical Pharmacology,Central South University,Changsha 410078,China ~4 Affiliated XiangyaHospital of Central South University,Changsha 410078,China ment of Epidemic and Health Statistics School of Public Health Central South University Changsha 410078 China. xybms@***.

Aim:To detect 388G>A and 521T>C variant alleles in the organic anion trans-porting polypeptide-1B 1 （OATP 1B 1,encoding gene SLCO 1B 1） ***:One hundred and eleven healthy volunteers were screened for OATP1B 1 alleles inour ***-restriction fragment length polymorphism was used to identifythe 388G>A polymorphism and a 1-step tetra-primer method was developed forthe determination of 521T>C ***:The frequencies of the 388G>Aand 521T>C variant alleles in the chinese population were 73.4% and 14.0%,*** frequencies of the SLCO1B1*1b and*15 haplotypes were59.9% and 14.0%,***:The SLCO1B1*1b and SLCO1B1*15variants are relatively common in the chinese *** frequencies aresimilar to that in the Japanese,but significantly different from that in Caucasiansand blacks.

关键词： organic anion transporting polypeptide-1B1 388G>A 521T>C genotyping chinese patients

Analysis and comparison of two low-dosage warfarin regimens in chinese patients

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Journal of chinese Pharmaceutical Sciences 2013年第1期22卷 95-100页

作者： Guy-Armel Bounda Cosette Ngarambe 葛卫红于锋中国药科大学药学院临床药学教研室江苏南京210009 东南大学医学院江苏南京210096 南京大学医学院附属鼓楼医院药剂科江苏南京210008

Oral anticoagulation therapy with warfarin is used to prevent and treat venous and arterial thrombosis and embolism. Its narrow therapeutic index should be monitored carefully in order to reach the desired outcomes. The complexity of the pharmacokinetic and pharmacodynamics profile of warfarin makes it a challenge to use during treatment. Its manufacturing characteristics play a key role in its dosage. The aim of this study is to examine and evaluate the effect of two different warfarin regimens in chinese patients. A cross-sectional study design was adopted. Medical records of all patients （n = 368） who received warfarin therapy in cardio-thoracic surgery wards between Sep. 2008 and Dec. 2009 were reviewed. Details of antithrombotic results of international normalized ratio （INR） monitoring were obtained. Statistical analysis was performed to assess factors predictive of INR therapeutic range at patients＇ discharge time according to different warfarin regimens （2.5 mg in China and 3.0 mg in USA）. The patients＇ mean age was （48.23~12.96） years. The percentage of patients within the INR therapeutic range in the group treated with 2.5 mg warfarin （35.17%） was much lower than that in group treated with 3.0 mg warfarin （47.72%）. Therefore, a significance difference was observed （P = 0.032〈0.05）. In this study, statistical values have shown that most of the patients were related to medical case requesting INR target range of 1.8-2.2 and 2.0-2.5, respectively. There was a statistically significant difference between the two groups. The study showed that the 2.5 mg-warfarin regimen was less suitable than the 3.0 mg-warfarin regimen. Medication regimen should be simplified as much as possible, especially during different treatment period.

关键词： Anticoagulation chinese patients Dose INR Low warfarin regimen

Analysis of long-term outcome of modified gastric bypass for type 2 diabetes mellitus in chinese patients

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World Journal of Clinical Cases 2024年第25期12卷 5697-5705页

作者： Ying Xing Ri-Xing Bai You-Guo Li Jun Xu Zhi-Qiang Zhong Ming Yan Wen-Mao Yan Department of General Surgery Beijing Tiantan HospitalBeijing 100170China

BACKGROUND Bariatric and metabolic surgery have been routinely performed following the rapid increase in obesity and metabolic diseases *** all evolving procedures,Roux-en-Y gastric bypass(RYGB)is considered the gold standard for surgical treatment of patients with type 2 diabetes mellitus(T2DM)and *** was introduced in China nearly 20 years ago,but the number of RYGB surgeries only accounts for 3.1%of the total number of weight loss and metabolic surgeries in China,it’s effect on chinese people still needs further *** To investigate the effect and safety of a modified gastric bypass performed in chinese patients with *** patients with obesity and T2DM who underwent modified gastric bypass,with>5-year follow-up data,were *** All 37 patients underwent uneventful laparoscopic surgery,no patient was switched to laparotomy during the surgery,and no severe complications were *** weight and body mass index of the patients reduced from 84.6±17.3(60.0–140.0)kg and 30.9±5.0(24.7–46.2)kg/m2 to 67.1±12.2(24.7–46.2)kg and 24.6±3.9(17.7–36.5)kg/m2,respectively,and fasting plasma glucose and glycated hemoglobin decreased from 7.4±3.4 mmol/L and 8.2%±1.7%preoperatively to 6.5±1.3 mmol/L and 6.5%±0.9%5-years postoperatively,*** 29.7%(11/37)of the patients used hypoglycemic drugs 5-years postoperatively,and the complete remission rate of T2DM was 29.7%(11/37).Triglyceride level reduced significantly but high-density lipoprotein increased significantly(both Ppatients’preoperative history of T2DM and fasting C-peptide were significant prognostic factors influencing complete T2DM remission after RYGB(P=0.006 and 0.012,respectively).CONCLUSION The modified gastric bypass is a safe and feasible procedure for chinese patients with obesity an

关键词： Laparoscopic Roux-en-Y gastric bypass chinese patients Metabolic surgery Bariatric surgery Type 2 diabetes mellitus

Gastroesophageal Junctional Carcinomas in chinese patients Are Different From Those in American patients

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Gastroesophageal Junctional Carcinomas in Chinese Patients A...

Effects of a Nurse-Led Educational Intervention for chinese Adult patients with Psoriatic Arthritis: A Case-Control Study

中华医学会病理学分会2009年学术年会

作者：黄勤樊祥山 Agoston T.Agoston 冯安宁余慧萍 Gregory Lauwers Robert D.Odze 张丽华南京大学医学院附属鼓楼医院病理科

In conclusion,GEJ carcinomas developed in chinese patients were gastric in origin and clinicopathologically different from those in Americans. These data may indicate different pathogenic mechanisms for GEJ carcinomas... 详细信息

关键词： Gastroesophageal Junctional Carcinoma chinese patients American patients

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Open Journal of Nursing 2016年第2期6卷 110-114页

作者： Bishan Cai Tiantian Xin Aizhen Yan Luna Wu Li Wang Physical Therapy Center Guangdong Provincial Center for Skin Disease and STIs Control and Prevention (Guangdong Provincial Dermatology Hospital) Guangzhou China Department of Dermatology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Inpatient Unit Guangdong Provincial Center for Skin Disease and STIs Control and Prevention (Guangdong Provincial Dermatology Hospital) Guangzhou China

The aim of this study was to evaluate the effect of an individual nurse-led educational intervention for patients with psoriatic arthritis (PsA). This was a case-control study. The case group consisted of six individual educational sessions delivered by a nurse. A total of 40 patients with PsA joined in this study: the case group (n = 20) and the control group (n = 18). After a 6-week intervention, the case group had significantly better management for the severity of arthritis symptoms (p patients with PsA.

关键词： Nurse-Led Interventions Psoriatic Arthristis chinese patients Case-Control Study