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DNA Methylation and Transcription of HLA-F and Serum Cytokines Relate to chinese medicine syndrome Classification in Patients with Chronic Hepatitis B

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chinese Journal of Integrative medicine 2022年第6期28卷 501-508页

作者： HU Xue-qing ZHOU Yuan CHEN Jian LU Yi-yu CHEN Qi-long HU Yi-yang SU Shi-bing Research Center for Traditional chinese medicine Complexity System Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Academy of Integrative medicine Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Vascular Disease Shanghai Traditional Chinese Medicine-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Department of Vascular Disease Shanghai Traditional Chinese Medicine-Integrated Institute of Vascular DiseaseShanghai201203China Institute of Liver Disease Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China

Objective:To explore the molecular bases of chinese medicine(CM) syndrome classification in chronic hepatitis B(CHB) patients in terms of DNA methylation,transcription and ***:Genome-wide DNA methylation and 48 serum cytokines were detected in CHB patients(DNA methylation:15 cases;serum cytokines:62 cases) with different CM syndromes,including dampness and heat of Gan(Liver) and gallbladder(CHB1,DNA methylation:5 cases,serum cytokines:15 cases),Gan stagnation and Pi(Spleen) deficiency(CHB2,DNA methylation:5 cases,serum cytokines:15 cases),Gan and Shen(Kidney) yin deficiency(CHB3,DNA methylation:5 cases,serum cytokines:16 cases),CHB with hidden symptoms(HS,serum cytokines:16 cases) and healthy controls(DNA methylation:6 cases).DNA methylation of a critical gene was further validated and its mRNA expression was detected on enlarged ***-wide DNA methylation was detected using Human Methylation 450 K Assay and further verified using *** and mRNA expression of gene were evaluated using multiplex biometric enzyme-linked immunosorbent assay(ELISA)-based immunoassay and reverse transcription-quantitative polymerase chain reaction(RT-qPCR),***:Totally 28,667 loci,covering 18,403 genes were differently methylated among CHB1,CHB2 and CHB3(P 0.17).Further validation showed that compared with HS,the hg19 CHR6:29691140 and its closely surrounded 2 CpG loci were demethylated and its mRNA expressions were significantly up-regulated in CHB1(P0.05).Levels of Interleukin(IL)-12 were higher in CHB3 and HS than that in CHB1 and CHB2 groups(P<0.05).Levels of macrophage inflammatory protein(MIP)-1αand MIP-1β were higher in CHB3 than other groups and leukemia inhibrtory factor level was higher in CHB1 and HS than CHB2 and CHB3 groups(P<0.05).IL-12,MIP-1α and MIP-1β concentrations were positively correlated with human leukocyte antigen F(HLA-F)mRNA expression(R

关键词： cytokine chronic hepatitis B DNA methylation human leukocyte antigen F chinese medicine syndrome

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Study on chinese medicine syndrome of Colorectal Carcinoma in Perioperative Period

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chinese Journal of Integrative medicine 2015年第3期21卷 183-187页

作者：郭勇邹莹徐玉芬王辉李妍钱丽燕杨维泓 Zhejiang Provincial Hospital of Traditional chinese medicine Zhejiang chinese Medical University

Objective：To explore the distribution characteristics of chinese medicine（CM） syndromes and the rule of dynamic evolvement in patients with colorectal cancer at the perioperative period by applying a mathematical statistics ***：By using the overall sample date,and cross-sectional descriptive and prospective researching methods,the clinical data of CM symptoms of patients with colorectal cancer from the first day of preoperative care to the third,seventh,and tenth days after the operation were *** distribution characteristics of CM syndromes and dynamic evolution were concluded upon by experts,and then by building up a database through the use of EpiData3.1 the frequency statistics and cluster analyses were applied utilizing ***：Among 210 cases of patient,on the day before the operation,the main route of syndrome was blood deficiency（33.33%）,followed by the syndrome of deficiency of both qi and yin（28.57%）.On the third day after surgery,the main syndrome was qi deficiency（47.62%）,followed by yin deficiency *** the seventh day after surgery,the main syndrome was both yin deficiency inner-heat（33.33%） and phlegm-dampness（33.33%）.On the tenth day after surgery,the main syndrome was a deficiency of both qi and yin（38.09%）,followed by dampness and hot accumulative knotting（33.33%）.Conclusion：Research in the field of the distribution characteristics of CM syndromes and dynamic evolution will provide an objective basis for syndrome differentiation for patients in the perioperative period,further advancing the study of preventing and decreasing relapse and metastasis in CM therapy.

关键词： colorectal carcinoma perioperative period chinese medicine syndrome cluster analyses

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Exploring Molecular Mechanism underlying chinese medicine syndrome:A Study on Correlation between chinese medicine syndrome and Biomarkers for Ischemic Stroke

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chinese Journal of Integrative medicine 2014年第1期20卷 11-18页

作者：刘璐高颖马斌 Department of Neurology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Objective：To investigate whether chinese medicine（CM）syndrome is associated with particular molecular mechanism,we explored the correlation between CM syndrome and changes of intercellular adhesion molecule-1（ICAM-1）,matrix metalloproteinase 9（MMP-9）and heat shock protein 70（HSP70）in patients with ischemic stroke,which were reported to play an important role in the inflammatory and apoptosis ***：CM syndrome factors of 175 patients with ischemic stroke were assessed using Ischemic Stroke CM syndrome Factor Diagnostic Scale（ISTSFDS）.The patients were grouped according to the main syndrome factor combinations at different time points based on distribution probability of syndrome factor *** levels of ICAM-1,MMP-9 and HSP70 were quantified by enzyme-linked immunosorbent ***：ICAM-1 expression was significantly higher in the internal-wind＋phlegm-dampness＋blood-stasis,phlegmdampness＋blood-stasis,internal-fire＋phlegm-dampness＋blood-stasis group than that in the blood-stasis＋qideficiency group within 72 h from stroke onset（P〈0.05）;HSP70 expression was significantly lower in the phlegm-dampness＋blood-stasis,internal-fire＋phlegm-dampness＋blood-stasis,blood-stasis group than that in the phlegm-dampness＋blood-stasis＋qi-deficiency group on the 7th day from stroke onset（P〈0.05）.Conclusions：Phlegm-dampness and blood-stasis exist through the whole process of ischemic *** increased level of ICAM-1 and a reduced level of HSP70 reflect the pathological state of phlegm-stasis mutual *** results suggest that inflammation and apoptosis induced by cerebral vascular injury in the pathological processes of ischemic stroke are more prominent in the excess syndrome state like phlegm-dampness and blood-stasis.

关键词： ischemic stroke chinese medicine syndrome intercellular adhesion molecule-1 matrix metalloproteinase 9 heat shock protein 70

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Bone Marrow Angiogenesis in Patients Presenting with Differential chinese medicine syndrome:Correlation with the Clinico-pathological Features of Aplastic Anemia

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chinese Journal of Integrative medicine 2013年第12期19卷 905-912页

作者：吴迪炯叶宝东胡致平沈一平沈建平林圣云陈明涛刘永林周郁鸿 Department of Hematology the First Affiliated HospitalZhejiang University of Traditional Chinese Medicine

Objective： To explore differences in bone marrow angiogenesis seen in aplastic anemia （AA） patients presenting with differential chinese medicine （CM） syndrome, and to correlate these differences with clinical pathology. Methods： Thirty-five patients were enrolled, including 18 with ＂yang deficiency syndrome＂ and 17 with ＂yin deficiency syndrome.＂ Bone marrow biopsies and serum were collected. Microvessel density （MVD） and positive expression of vascular endothelial-derived growth factor （VEGF） were detected by immunohistochemisty. Hypoxia inducible factor -α （HIF-α ）, and VEGF expression were assayed by enzyme-linked immunoabsorbent assay （ELISA）, serum lactate dehydrogenase （LDH） was tested by enzyme method and liquid chip technology was used to detected the expression of interleukin （IL）-2, IL-4, IL-6, IL-10, interferon （IFN）-＇y and tumor necrosis factor （TNF）-α. Results： Counts for leukocytes, absolute neutrophils and platelets in ＂yin deficiency syndrome＂ were lower than those found in ＂yang deficiency syndrome＂（P〈0.05）. MVD and VEGF expression, and the positive rate of CD34 and VEGF in bone marrow were lower in hA, especially in ＂yin deficiency syndrome＂（P〈0.01 or P〈0.05）. ＂Yin deficiency syndrome＂ displayed decreased VEGF and LDH expression, and enhanced expression of HIF-α as compared to ＂yang deficiency syndrome＂（P〈0.05）. Levels of IL-4 and IL-6 were higher in AA （P〈0.01）, but IL-10 was decreased （P〈0.05）. High TNF-c~ expression was seen in ＂yang deficiency syndrome＂ and IFN- γ expression was decreased in ＂yin deficiency syndrome＂ as compared with normals （P〈0.01 and P〈0.05, respectively）. Conclusion： AA patients have lower MVD than normals, especially in ＂yin deficiency syndrome.＂ MVD might differentially correlate to disease severity, and could be dependent on bone marrow or serum VEGF expression and LDH. Additionally, IL-2, IL-10, IL-4 and IFN- γ were negatively associated while IL-6 and TNF- α were positively associated with MVD.

关键词： aplastic anemia angiogenesis chinese medicine syndrome clinico-pathological vascular endothelial- derived growth factor tumor necrosis factor-αL

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Correlation between Characteristics of Coronary Plaque and chinese medicine syndromes of Coronary Heart Disease:A Cross-Sectional Study Analysed by Intravascular Ultrasound

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chinese Journal of Integrative medicine 2022年第9期28卷 840-846页

作者： XU Dan-ping XU Jun-peng HE Zhi-ling PAN Guang-ming WANG Xia Department of Cardiology the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120Chin Postdoctoral Station of Fujian University of chinese medicine Fuzhou350122China The Second Clinical College of Guangzhou University of chinese medicine Guangzhou510120China

Objective:To analyse the correlation between the characteristics of coronary plaque in coronary heart disease(CHD)patients with phlegm-blood stasis syndrome(PBS)and blood stasis syndrome(BSS).Methods:Patients were divided into different groups based on chinese medicine(CM)syndrome *** baseline demographics and clinical variables were collected from the medical ***,the characteristics of plaque and pathological manifestations in coronary artery were evaluated intravascular ultrasound(IVUS).Results:A total of 213 CHD patients were enrolled in two groups:184 were diagnosed with PBS and the remaining 29 were diagnosed with *** were no significant differences in age,body mases index,proportions of patients with high blood pressure,diabetes mellitus,smoking,hyperlipidemia,history of coronary artery bypass graft and percutaneous coronary intervention,medications,index from cardiac ultrasound image,blood lipids and C-reactive protein between the two groups(P>0.05),except gender,weight and proportions of OVUS observed target vessels(P<0.05 or P<0.01).More adverse events such as acute myocardial infarction(P=0.003)and unstable angina(P=0.048)were observed in ***,dissection,thrombus and coronary artery ectasia were significantly increased in BSS(P<0.05 or P<0.01).In contrast,PBS had more patients with stable angina and chronic total occlusion with significantly higher SYNTAX(synergy between percutaneous coronary intervention with Taxus and coronary artery bypass surgery)scores(P<0.05 or P<0.01).Moreover,dense-calcium was significantly elevated in PBS(P<0.01).Conclusions:Coronary plaque characteristics were correlated with different CM *** with PBS were associated with a higher degree of calcified plaque and severe coronary artery stenosis,indicating poor clinical prognosis but with a low probability of acute coronary *** contrast,the degree of calcified plaque in patients with BSS remained relatively low,

关键词： coronary heart disease coronary plaque intravascular ultrasound chinese medicine syndrome syndrome differentiation

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Circulating Levels of Inflammatory Cytokines in Patients with Psoriasis Vulgaris of Different chinese medicine syndromes

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chinese Journal of Integrative medicine 2015年第2期21卷 108-114页

作者：禤美玲卢传坚韩凌项瑜 Department of Dermatology Guangdong Provincial Hospital of Traditional Chinese Medicine

Objective： To investigate whether the serum levels of inflammation-related cytokines might be different between the healthy individuals and the psoriatic patients diagnosed of three varied chinese medicine （CM） syndromes [blood-stasis syndrome （BSS）, blood-dryness syndrome （BDS） and wind-heat syndrome （WHS）]. Methods： A total of 62 psoriatic patients were recruited and assigned to 3 groups according to their CM syndromes, including 27 patients of BSS, 21 of BDS and 14 of WHS. Another 20 sex- and age- matched healthy subjects were enrolled into the control group. Serum concentrations of multiple cytokines, including monocyte chemotactic protein-1 （MCP-1）, macrophage inflammatory protein-1α （MIP-1α）, soluble CD40 ligand （SCD40L）, tumor necrosis factor-α （TNF-α）, epidermal growth factor （EGF）, interleukin-8 （IL-8）, interleukin-17 （IL-17）, interferon γ inducible protein-10 （IP-10） and vascular endothelial growth factor （VEGF）, were measured by a multiplexed flow cytometric assay. Results： The circulating levels of MIP-1α, TNF-α, IL-8, and IP-10 were significantly increased in the psoriatic patients compared with the healthy controls （P〈0.01）. Male and female patients tended to have higher serum levels of MCP-1 and IP-10, respectively （P〈0.05）. Interestingly, compared with the control group, 6 out of the 9 cytokines （MCP-1, MIP-1α, TNF-α, EGF, IL-8 and IP-10） were substantially increased in the BSS group （P〈0.05 or P〈0.01）, whereas only MIP-1α and IL-8 levels were elevated in the BDS group （P〈0.05 or P〈0.01） concurrent with lowered concentrations of SCD40L and IL-17 （P〈0.05）. In the WHS group, MIP-1α was the only cytokine whose level was evidently increased （P〈0.01）, in contrast to IL-17 which was decreased as compared with the control （P〈0.05）. The psoriatic patients overall owned higher levels of MIP-1 a and IL-8 in the circulation which were comparable among the 3 groups of CM syndromes （P〈0.01）. In contrast, TNF-α level of the BSS group was the highest among the thre

关键词： psoriasis vulgaris blood-stasis syndrome blood-dryness syndrome wind-heat syndrome cytokines chinese medicine syndrome

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Expression of PYCARD Gene Transcript Variant mRNA in Peripheral Blood Mononuclear Cells of Primary Gout Patients with Different chinese medicine syndromes

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chinese Journal of Integrative medicine 2018年第1期24卷 24-31页

作者： DANG Wan-tai XIE Wen-guang ZHOU Jing-guo School of Clinical medicine Chengdu University of Traditional Chinese Medicine Institute of Rheumatology and Immunology Affiliated Hospital of North Sichuan Medical College

Objective： To study the expression level and role of apoptosis-associated speck-like protein containing a caspase recruitment domain （PYCARD） gene transcript variant mRNA in peripheral blood mononuclear cells （PBMCs） of primary gout （PG） patients with different chinese medicine （CM） syndromes. Methods： The expressions of PYCARD gene transcript variant mRNA and interleukin-1β （IL-1β） mRNA in PBMCs were investigated in 96 PG patients with acute phase （APPG, 44 cases） and non-acute phase （NAPPG, 52 cases） and 30 healthy controls （HCs） by reverse transcription-polymerase chain reaction （PCR） and/or real-time quantitative PCR. PYCARD and nuclear factor-κB （p50） [NF-κB （p50）] protein was detected by Western blot in PBMCs respectively. IL-1β, IL-4 and IL-10 protein levels in plasma of HCs and PG patients were measured by enzyme-linked immuno sorbent assay. Results： The main CM syndromes in APPG patients were obstruction of dampness and heat syndrome （ODHS, 36.36%） and intermingled phlegm-blood stasis syndrome （IPBSS, 27.27%）, while in NAPPG patients were Pi （Spleen）-deficiency induced dampness syndrome （PDIDS, 40.38%） and qi-blood deficiency syndrome （QBDS, 26.92%）. It showed statistical significances of the expressions of PYCARD gene and its transcript variant mRNA, the protein of PYCARD and NF-κB （p50） and the plasma IL-1β, IL-4 and IL-10 in APPG, NAPPG, ODHS, IPBSS, PDIDS and QBDS groups, compared with the HC group respectively （P〈0.05 or P〈0.01）. There were also significant differences of mRNA expressions of PYCARD-1 and PYCARD-2 as well as protein expressions of IL-1β, IL-4 and IL-10 among the 4 CM syndromes groups （P〈0.05 or P〈0.01）. Correlation analysis showed positive correlation between the mRNA expressions of PYCARD-1 gene transcript variant and IL-1β in APPG patients （r=0.3088, P=0.0183）. Conclusion： PYCARD gene and its transcript variant may play a critical and regulative role in the inflammatory response of PG patients with different phases and CM syndromes.

关键词： chinese medicine syndrome primary gout PYCARD gene transcript variant

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Analysis on the chinese medicine syndromes and Demographic Characteristics of Patients with Influenza-Like Illness in Clinics of China

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chinese Journal of Integrative medicine 2014年第2期20卷 101-106页

作者：欧爱华卢传坚李际强李晓彦温泽淮邓华薛素琴欧阳文伟 Guangdong Provincial Hospital of chinese medicine Guangdong Provincial Academy of chinese Medical Science

Objective： To investigate chinese medicine （CM） patterns and epidemiological characters of patients with influenza-like illness （ILI） syndromes in clinics in China. Methods： A prospective multi-center observational epidemiology survey on the clinical CM patterns of ILI and its prevalence was conducted from September 2009 to April 2010. A unified survey questionnaire was developed for data collection of ILI symptoms and CM pattems. Totally 45 hospitals from 22 provinces, municipality cities and autonomous regions of China participated this study. The collected data were input by EPI-data v3.1 and analyzed by SPSS 18.0, which included descriptive analysis and Chi-square test for group comparison. Results： A total of 5,967 ILI patients were included in the study. The proportion of the 18-34 aged group （56.2%） was the largest; students （41.0%） were more than other occupations. Majority of the patients had the wind-heat invading Lung （Fei） syndrome （76%）, while in Southwest China mainly wind-heat invading Lung syndrome and wind-cold tightening the exterior syndrome occurred. The typical symptoms of ILI were ranked as fatigue （80.9%）, cough （72.2%）, sore throat （67.2%）, muscular soreness （67.1%）, headache （65.4%）, aversion to cold （60.1%）, thirst （55.1%） and nasal obstruction （48.1%）. Conclusions： The ILl patients in clinics were mainly teenagers and young adults. In regard to CM syndrome, wind-heat invading Lung syndrome prevailed in all regions except the Southwest China. The characteristics of CM syndrome of ILl patients may be relevant to age and region distribution.

关键词： clinic influenza-like cases chinese medicine syndrome epidemiology multi-center survey

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Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated chinese and Western medicine

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chinese Journal of Integrative medicine 2023年第4期29卷 308-315页

作者： QU Yi-lun DONG Zhe-yi CHENG Hai-mei LIU Qian WANG Qian YANG Hong-tao MAO Yong-hui LI Ji-jun LIU Hong-fang GENG Yan-qiu HUANG Wen LIU Wen-hu XIE Hui-di PENG Fei LI Shuang JIANG Shuang-shuang LI Wei-zhen DUAN Shu-wei FENG Zhe ZHANG Wei-guang LIU Yu-ning TIAN Jin-zhou CHEN Xiang-mei Department of Nephrology First Medical Center of Chinese People's Liberation Army General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Guangdong Metabolic Diseases Research Center of Integrated chinese and Western medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaInstitute of Chinese MedicineGuangdong Pharmaceutical UniversityGuangdong Traditional Chinese Medicine Key Laboratory for Metabolic DiseasesGuangzhou 510006China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology The Forth Medical Center of People's Liberation Army General HospitalBejing 100039China Department of Endocrinology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBejing 100700China Department of Nephrology The Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Nephrology Beijing Friendship HospitalFaculty of Kidney DiseasesCapital Medical UniversityBeijing 100050China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China

Objective:To investigate the factors related to renal impairment in patients with diabetic kidney disease(DKD)from the perspective of integrated chinese and Western ***:Totally 492 patients with DKD in 8 chinese hospitals from October 2017 to July 2019 were *** to Kidney Disease Improving Global Outcomes(KDIGO)staging guidelines,patients were divided into a chronic kidney disease(CKD)1-3 group and a CKD 4-5 *** data were collected,and logistic regression was used to analyze the factors related to different CKD stages in DKD ***:Demographically,male was a factor related to increased CKD staging in patients with DKD(OR=3.100,P=0.002).In clinical characteristics,course of diabetes>60 months(OR=3.562,P=0.010),anemia(OR=4.176,Psyndrome(OR=1.945,P=0.020)were factors related to increased CKD staging in patients with ***:Male,course of diabetes>60 months,anemia,hyperuricemia,massive proteinuria,atherosclerosis,and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD.(Registration ***03865914).

关键词： diabetickidney disease integrated chinese and Western medicine chinese medicine syndrome

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Evidence-Based Dampness-Heat ZHENG(syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

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chinese Journal of Integrative medicine 2024年第1期30卷 85-95页

作者： JIAO Ju-ying CHENG Chien-shan CAO Zhang-qi CHEN Lian-yu CHEN Zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.

关键词： cancer chinese medicine syndrome ZHENG dampness-heat syndrome animal model pancreatic tumor evaluation methods

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