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chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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Neural Regeneration Research 2015年第3期10卷 445-450页

作者： Peiman Alesheikh Arezou Mashoufi Hui-ling Tang Wei Zhang Bo Di Yang-yang Yan Peng-tao Li Yan-shu Pan Research Center of Natural Product Health North Khorasan University of Medical Science Department of Pathology Preclinical Medical SchoolBeijing University of Chinese Medicine Dongzhimen Hospital Affiliated to Beijing University of chinese Medicine

The chinese herbal formula Tongluo fiunao, containing the active components Panax notogin- seng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control （Xuesai Tong, containing Panax notoginseng） or saline intraperitoneally to investigate the pathway involved in the action of TongIuo fiunao injection. 2,3,5-Triphenyltetrazolium chloride （TTC） staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo fiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo fiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/ tropomyosin-related kinase C pathway.

关键词： neural regeneration cerebral ischemia chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration

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chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms

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World Journal of Gastroenterology 2022年第33期28卷 4890-4908页

作者： Wei Jin Juan Zhong Yang Song Ming-Fei Li Shi-Yi Song Chun-Run Li Wei-Wei Hou Qing-Jie Li Department of Emergency Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Chengdu University of Traditional chinese Medicine Chengdu 610075Sichuan ProvinceChina Interventional Operation Room Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

BACKGROUND Chronic gastritis(CG) is an inflammatory disease of the gastric mucosa. Shenling-bai-zhu san(SLBZS), a traditional chinese medicine formula, is widely used for treating CG. Nevertheless, its effects are currently *** To determine the clinical evidence and potential mechanisms of SLBZS for the treatment of *** We systematically searched 3 English(PubMed, Embase, Medline) and 4 chinese databases(Cochrane Library Central Register of Controlled Trials, China National Knowledge Infrastructure database, Wanfang Data Knowledge Service Platform,and the VIP information resource integration service platform) without language or publication bias restriction. Qualified studies were selected according to pre-set inclusion and exclusion criteria. RevMan 5.3 software was used for meta-analysis and literature quality assessment, Stata 14.0 software was used for sensitivity analysis, GRADE profiler 3.6 was used to evaluate the quality of evidence. And then, network pharmacology analysis was applied to primary research the mechanisms of action of SLBZS on *** Fourteen studies were finally included, covering 1335 participants. Meta-analysis indicated that:(1) SLBZS was superior to conventional therapies [risk ratio(RR):1.29, 95% confidence interval(CI): 1.21 to 1.37, P < 0.00001];(2) SLBZS was better than conventional therapies [RR: 0.24, 95% confidence interval(95%CI): 0.11 to 0.55, P = 0.0007] in terms of recurrence rate and reversal of Helicobacter pylori positivity(RR: 1.20, 95%CI: 1.11 to 1.30,P < 0.00001);and(3) The safety of SLBZS for CG remains unclear. According to the GRADE method, the quality of evidence was not high. Besides, SNZJS might treat CG by acting on related targets and pathways such as EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, and *** SLBZS might be useful in treating CG, but long-term effects and specific clinical mechanisms of it maintain unclear. More samples and high-quality clini

关键词： Chronic gastritis Shen-ling-bai-zhu-san chinese herbal formula Systematic review Network pharmacology

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The chinese herbal formula Weichang’an Reduces the Proliferation of Human Gastric Cancer Cells via Mitochondrial Apoptosis

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chinese Medicine and Natural Products 2024年第3期4卷 117-125页

作者： Weixia Chen Yaofei Niu Bin Chen Aiguang Zhao Department of Oncology Henan Province Hospital of Traditional Chinese MedicineZhengzhouHenanChina Department of Oncology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Infection Henan Provincial People’s Hospital/Zhengzhou University People’s HospitalZhengzhouHenanChina Department of Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Objective The aim of the study was to investigate the effects of chinese herbal formula Weichang’an(WCA)on the proliferation and mitochondria-mediated apoptosis of human gastric cancer *** Cell Counting Kit-8(CCK8)was used to evaluate the antiproliferative activity ofWCA on MKN45 cells;Giemsa staining was used to investigate cell colony formation;flow cytometry was used to analyze cell cycle,apoptosis rate,and caspases activation;and Hoechst staining was used to analyze the morphology of cell *** mitochondrial membrane potential was analyzed by both flow cytometric measurements and fluorescence *** blot was used to analyze the protein levels of pro-caspase-3,Bcl-2,Bax,and ***45 cells were subcutaneously injected into the right forelimb of 16 nude mice to establish the tumor xenograft model,and a total of 12 nude mouse tumor xenograft models were successfully *** nude mice were divided into the control group and the WCA-treated *** two groups received normal saline and WCA treatment at 35.49 g/kg by a single daily oral gavage for 21 *** body weight and tumor size of the nude mice were measured twice a *** ultrastructural changes of subcutaneous tumors were observed by a transmission electron *** WCA can suppress cell proliferation and colony *** can also induce changes in the mitochondrial membrane potential and increase the activities of caspases-3,caspases-8,and caspases-9 in MKN45 *** induced S-phase arrest and apoptosis in MKN45 cells,and decreased the expression levels of antiapoptotic proteins Bcl-2 and Bcl-X in MKN45 cells,while increasing the expression levels of the proapoptotic proteins Bax and pro-caspase-3 compared with the control *** inhibited the growth of a xenografted MKN45 tumor in nude mice,and the protein levels of Bax and pro-caspase-3 were significantly increased,while Bcl-X and Bcl-2 were reduced compared with the control *** differences are

关键词： gastric cancer chinese herbal formula Weichang’an mitochondrial apoptosis

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formula and Pharmacological Identification of Diarrhea Arresting and Dysentery Treating Dietary Traditional chinese herbal Medicine for Livestock

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Agricultural Science & Technology 2014年第8期15卷 1374-1375,1399页

作者：蔡璐蒋秀全杨何蔡一鸣贵州省生物技术研究所贵州贵阳550006 贵州省畜牧兽医研究所贵州贵阳550005 贵州省草业研究所贵州贵阳550006

This study was aimed to develop the chinese herbal formula with dysentery arresting and antidiarrheal effect. [Method] The chinese herbal for-mulation was used to carry out the clinical curative effect test and pharmacological test for il livestock. [Results] Curative effect test showed that the formula had good effect on abdominal pain, diarrhea and fecal changes of livestock, and the cure rate reached up to 92%. Pharmacological experiments showed that the formula had sig-nificant inhibitory effect on the gastrointestinal motility of the tested animals, and the diarrhea arresting and dysentery treating effect of the formula was also extremely significant. In addition, the formula was safe for tested animals, proving to be reli-able. [Conclusion] The formula has distinct curative effect on treating white scour of piglets, yel ow scour of piglets, livestock gastroenteritis and lienteric diarrhea, and it can also be used in veterinary clinic, as wel as be used as feed additive.

关键词： chinese herbal formula Curative effect testing Pharmacological testing

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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： ZHANG Shao-yan QIU Lei ZHANG Shun-xian XIAO He-ping CHU Nai-hui ZHANG Xia ZHANG Hui-qiang ZHENG Pei-yong ZHANG Hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in China from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P<0.01). Overall, the death rates in the two groups were not significantly different;5.1%(8/156) in the BFJD Granules group and 2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

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A Yang-invigorating compound mixture alters neurotransmitters in rat telencephalon after exercise-induced fatigue

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Neural Regeneration Research 2011年第15期6卷 1158-1163页

作者： Hongzhen Liu Li Zeng Xiliang Kong Lei Zhu Benhua Hou Qufu Normal University Qufu 273165 Shandong Province China People's Sports Publishing House Beijing 100061 China

The aim of this study was to observe the changes in monoamine and amino acid neurotransmitters in the telencephalon of rats at four functional states after exhaustive exercise and treatment with a Yang-invigorating compound *** main components of this chinese traditional medicine preparation included Radix Ginseng,Rhizoma Chuanxiong,Fructus Schisandrae,Cortex Cinnamomi,Cornu Cervi Pantotrichum,Radix Morindae Officinalis,and *** experiment showed that dopamine（DA）,5-hydroxyindole acetic acid（5-HIAA）,and γ-aminobutyric acid levels noticeably decreased,while DA/5-hydroxytryptamine（5-HT） ***,glutamate（Glu） and Glu/γ-aminobutyric acid significantly increased after 1 hour of exercise in rats in the exercise ＋ medication *** 5-HT and 5-HT/5-HIAA levels noticeably decreased,and DA/5-HT and Glu levels showed a robust and significant increase immediately after exhaustive *** 5-HT,5-HT/5-HIAA levels sharply decreased,while DA/5-HT,Glu and γ-aminobutyric acid levels increased at 12 hours after exhaustion *** results prove that chinese herbal formula for strengthening Yang can induce changes in neurotransmitters in the telencephalon of rats after exhaustive exercise during the recovery process,and further improve central nervous system function.

关键词： chinese herbal formula neurotransmitter exercise training exhaustive exercise excitability neural regeneration

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Effects of Fujian tablet on Nogo-A mRNA expression and plasticity of the corticospinal tract in a rat model of focal cerebral ischemia

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Neural Regeneration Research 2011年第33期6卷 2577-2581页

作者： Wei Liu Yonghong Zhou Qing Jia Bingbing Han Guoli Zhang Department of Encephalopathy Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250011 Shandong Province China Department of Traditional chinese Medicine Medical College of Qingdao University Qingdao 266071 Shandong Province China Institute of Basic Medicine Shandong Academy of Medical Science Jinan 250062 Shandong Province China College of Basic Medical Sciences Jinan 250355 Shandong Province China Department of Radiation Oncology Shandong Tumor Hospital ＆ Institute Jinan 250117 Shandong Province China

The present study investigated the effects of Fujian tablet, a chinese medicine compound that can nourish liver and kidney, on corticospinal tract plasticity and cervical cord microenvironment in rats with focal cerebral ischemia. Results showed that motor function of rats with right proximal middle cerebral artery occlusion was significantly improved following treatment with Fujian tablet, 9 g crude drug/kg. Anterograde tracing revealed significantly increased biotinylated dextran amine expression in the denervated （left） side of the cervical cord （C4-6） following Fujian tablet treatment, and significantly decreased Nogo-A mRNA expression was detected in the denervated side of the cervical cord （C4-6） using in situ hybridization. Pearson＇s correlation analysis showed a negative correlation between biotinylated dextran amine and Nogo-A mRNA expression （r = -0.943, P 〈 0.01）. Results demonstrated that Fujian tablet can promote corticospinal tract plasticity possibly through the inhibitory effect on Nogo-A mRNA expression in the cervical spinal cord, thereby improving motor dysfunction.

关键词： Fujian tablet focal cerebral ischemia corticospinal tract Nogo-A mRNA chinese herbal formula neural plasticity neural regeneration

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Potential mechanism of Huatan Qushi decoction on improving phlegm-dampness constitution using microRNA array and RT-qPCR targeting on hsa-miR-1237e3p

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Journal of Traditional chinese Medical Sciences 2021年第1期8卷 43-51页

作者： Xiuping Zhang Ji Wang Baoxing Liu Haiqiang Yao Yu Chen Yuqing Yin Xuejing Yang Lingru Li Department of Gynecology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Center for Studies in Constitution Research of Traditional chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Andrology China-Japan Friendship HospitalBeijing 100029China Department of Nutriology China-Japan Friendship HospitalBeijing 100029China Memorial Sloan Kettering Cancer Center New YorkNY10065USA

Background:Metabolic diseases pose considerable burden on the healthcare system worldwide,indicating the significance of prevention and *** constitution theory of traditional chinese medicine,phlegm-dampness constitution(PDC)is the common basis of metabolic *** clinical practice,Huatan Qushi(HTQS)decoction targeting on PDC can effectively improve metabolic ***,its underlying biochemical mechanism still remains ***:Eight PDC participants received HTQS decoction for three *** blood was collected at baseline and 1 and 3 months after intervention *** biomedical indicators were ***-throughput sequencing and RT-qPCR were used for *** to the missing data,repeated measures with missing values in mixed models were ***:After 3-month treatment,HDL-C level increased(P<.001)and FBG,FINS,and HbA1c all showed decreasing trend at different time points(all P<.05).After miRNA high-throughput sequencing,compared with the baseline,differential miRNAs at 1 and 3 months were screened,and target gene prediction and KEGG pathway enrichment analysis were *** results displayed that metabolic disease-related pathways mainly included pathways in cancer,PI3K-Akt signaling pathway,***,RT-qPCR showed that hsa-miR-1237e3p differed statistically(P=.008).Then we validated the target genes of hsa-miR-1237e3p in the“Pathways in Cancer”pathway including SDF1,AC,CRK,and HGF,also known as upstream target genes of PI3K/AKT *** results showed that two indicators of CRK and HGF were in statistical significance(P=.045 and P=.036,respectively).Conclusion:PDC serves as a common basis for various metabolic *** adjusting PDC,HTQS decoction can improve biomedical indicators including blood glucose,HbA1c,insulin,and *** target pathway is“Pathways in cancer”.Specifically,HTQS decoction acts on targets of CRK and HGF by regulating hsa-miR-1237e3p,and probably exerts effects on t

关键词： chinese herbal formula Constitution Metabolic disorders Pathways in cancer

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Effectiveness and safety of Xuefu Zhuyu oral liquid(血府逐瘀口服液)on Qi-stagnation and blood-stasis pattern in patients with stable angina,tension-type headache and primary dysmenorrhea:rationale and design of a master protocol

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Journal of Traditional chinese Medicine 2023年第4期43卷 815-823页

作者： CAO Wencong LIAO Shaojun ZHANG Yuanwen ZHOU Li LI Geng OUYANG Wenwei WEN Zehuai Second Clinical Medical College(Second Affiliated Hospital) Guangzhou University of Chinese MedicineGuangzhou 510405China First Clinical Medical College(First Affiliated Hospital) Guangzhou University of Chinese MedicineGuangzhou 510405China Key Unit of Methodology in Clinical Research Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China State Key Laboratory of Dampness Syndrome of chinese Medicine Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China

We present the rationale and design of a master protocol study that clarifies the effectiveness and safety of chinese herbal formulas on Qi-stagnation and blood-stasis pattern(QBP).Three randomized controlled trials(RCTs)and real-world observational *** on three registry cohorts of stable angina,tension-type headache and primary dysmenorrhea,patients with QBP will be enrolled in RCTs to receive either Xuefu Zhuyu(血府逐瘀,XFZY)oral liquid or a placebo,while patients with non-QBP will be enrolled in the observational studies and experience follow-up.1414 patients(RCTs:574;observational studies:840)will be recruited at seven centers in China over a 3-year *** primary outcome is the visual analog scale of pain *** events will also be *** analysis will be undertaken separately in each sub-study,and then an overall analysis combining multiple subgroups will be performed to comprehensively investigate the effect of XFZY oral *** study will provide high-quality evidence of XFZY oral liquid for QBP patients and show a paradigm of post-marketing evaluation of the effectiveness and safety for chinese medicine following the notion of the pattern dominating different disease research models.

关键词： angina stable tension-type headache primary dysmenorrhea chinese herbal formula chinese medicine pattern master protocol

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Efficacy of integrative medicine in deficiency of both qi and yin in the rat model of type 2 diabetes

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Journal of Traditional chinese Medical Sciences 2015年第4期2卷 258-263页

作者： Jing Zhao Jinna Liu Bangzhong Wang Yuanchao Yao Guangxia Zhang Biyuan Liu Yuanfeng Zhang Tian Xie Ming Xie School of Basic Medical Science Beijing University of Chinese MedicineBeijing 100029China

Objective:To establish a rat model of type 2 diabetes(T2DM)manifesting the chinese medicine syndrome pattern of both qi and yin deficiency for evaluating the efficacy of a chinese herbal formula(CHF),integrative medicine(IM),and pioglitazone(PIO)on T2DM indicators in the animal ***:The rat model was induced by a high-fat diet(HFD)and streptozotocin(STZ,30 mg/kg).CHF(3.4 g/kg),PIO(2.7 mg/kg),and IM(3.4 g CHF+2.7 mg PIO)were administered to rats once daily for 14 *** laboratory parameters were ***:Diabetic rats showed unsmooth fur,alopecia,reduced activity,huddling,somnolence,depression,pale or reddened tongue,damp/dark red tail,and high levels of water and food intake,urine volume,and stool weight,but weakened grip *** levels of serum SOD,Nat-Kt-ATPase,cAMP/cGMP,and a high level of iNOS were ***,hyperinsulinemia,insulin resistance,high levels of serum glucagon/IDE and pancreatic amylin,and low serum and pancreatic SS levels were evident as ***:A rat model of T2DM with both qi and yin deficiency was successfully *** appeared to be more efficacious than IM and PIO in the rat model of qi and yin deficiency pattern of T2DM,though IM and PIO were each found to have their merits and drawbacks in attenuating T2DM indicators in the rat model.

关键词： Type 2 diabetes Deficiency of both qi and yin Integrative medicine chinese herbal formula

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