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Blood Lipid Profile and Prevalence of Dyslipidemia in chinese adults

Biomedical and Environmental Sciences 2007年第4期20卷 329-335页

作者： WEN-HUA ZHAO JIAN ZHANG YI ZHAI YUE YOU QING-QING MAN CHUN-RONG WANG HONG LI YING LI XIAO-GUANG YANG chinese Center for Disease Control and Prevention 27 Nanwei Road Beijing 100050 China Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China Central Laboratory Beijing Center for Disease Control and Prevention Beijing 100013 China Department of Epidemiology Institute of Cardiovascular Disease Chinese Academy of Medical Sciences （CAMS） Beijing 100037 China

To investigate the plasma lipid levels in a national representative sample of subjects and to determine the prevalence of dyslipidemia in the chinese population. Methods Plasma lipid profile was analyzed using the data obtained during the chinese national nutrition and health survey （CNHS） in 2002 which involved 14 252 participants at the age of 18 years or older. Results The mean levels of total cholesterol （TC）, triglyceride （TG） and high density lipoprotein cholesterol （HDL-C） in the participants were 3.81 retool/L, 1.10 mmol/L, and 1.30 mmol/L, respectively. In the groups of participants at the age of 18-44 years, 45-59 years, and over 60 years the mean TC level was 3.70 mmol/L, 4.09 mmol/L and 4.21 mmol/L, respectively, and the mean TG level was 07 mmol/L, 1.21 mmol/L, 1.20 mmol/L, 1.29 mmol/L, 1.33 mmol/L, and 1.33 mmol/L, respectively. The prevalence of dyslipidemia in chinese adults was 18.6% and 22.2% in males and 15.9% in females. Dyslipidemia prevalence was higher in urban districts than in rural areas （21.0% vs. 17.7%）. The prevalence of hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterol was 2.9%, 11.9%, and 7.4% respectively among the participants. Conclusion Dyslipidemia has become one of the important health risk factors in the chinese population. There is no significantly difference in the prevalence of dyslipidemia between the groups of participants at the age of 45-59 years and over 60 years. This study provides important lipid profile data for policy making and guideline development for the prevention of dyslipidemia in the chinese population.

关键词： chinese adults Total cholesterol Triglyceride High density lipoprotein cholesterol Dyslipidemia

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Calcium requirements for chinese adults by cross-sectional statistical analyses of calcium balance studies： an individual participant data and aggregate data meta-regression

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chinese Medical Journal 2014年第24期127卷 4250-4257页

作者： Fang Aiping Li Keji Shi Haoyu He Jingjing Li He Department of Nutrition and Food Hygiene Peking University Health Science Center Haidian District Beijing 100191 China

Background chinese dietary reference intakes for calcium are largely based on foreign studies. We undertook meta- regression to estimate calcium requirements for chinese adults derived from calcium balance data in chinese adults. Methods We searched PubMed, Cochrane CENTRAL, and SinoMed from inception to March 5, 2014, by using a structured search strategy. The bibliographies of any relevant papers and journals were also screened for potentially eligible studies. We extracted a standardized data set from studies in chinese adults that reported calcium balance data. The relationship between calcium intake and output was examined by an individual participant data （IPD） and aggregate data （AD） meta-regression. Results We identified 11 metabolic studies in chinese adults within 18-60 years of age. One hundred and forty-one IPD （n=35） expressed as mg/d, 127 IPD （n=32） expressed as mg.kg body wt-l-d-1, and 44 AD （n=132） expressed as mg/d were collected. The models predicted a neutral calcium balance （defined as calcium output （Y） equal to calcium intake （C）） at intakes of 460 mg/d （Y=0.60C＋183.98） and 8.27 mg.kg body wt-l.d-1 （Y=0.60C＋3.33） for IPD, or 409 mg/d （Y=0.66C＋139.00） for AD. Calcium requirements at upper intakes were higher than that at lower intakes in all these models. Conclusion Calcium requirement for chinese adults 18-60 years of age approximately ranges between 400 mg/d and 500 mg/d when consuming traditional plant-based chinese diets.

关键词： calcium requirement chinese adults individual participant data aggregate data meta-regression

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Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in chinese adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in chinese adults

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Biomedical and Environmental Sciences 2002年第1期15卷 83-96页

作者： ZHOU BEI-FAN2Cooperative Meta-Analysis Group of the Working Group on Obesity in China Cooperative Meta-Analysis Group of the Working Group on Obesity in China

Objective For prevention of obesity in chinese population, it is necessary to definethe optimal range of healthy weight and the appropriate cut-off points of BMI and waistcircumference for chinese adults. The Working Group on Obesity in China under the supportof International Life Sciences Institute Focal Point in China organized a meta-analysis on therelation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studiesin all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed inthe 1990s. Data on waist circumference was available for 111411 persons and data on serumlipids and glucose were available for more than 80 000. The study populations located in21provinces, municipalities and autonomous regions in China's Mainland as well as inTaiwan. Each enrolled study provided data according to a common protocol and uniformformat. The Center for data management in Department of Epidemiology, Fu Wai Hospitalwas responsible for statistical analysis. Results and conclusion The prevalence ofhypertension, diabetes, dyslipidemia and clustering of risk factors all increased withincreasing levels of BMI or waist circumference. BMI at 24 with best sensitivity andspecificity for identification of the risk factors, was recommended as the cut-off point foroverweight, BMI at 28 which may identify the risk factors with specificity around 90 % wasrecommended as the cut-off point for obesity. Waist circumference beyond 85 cm for menand beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normalrange (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons(BMI≥28)with drugs could prevent 15%-17% clustering of risk factors. The waistcircumference controlled under 85 cm for men and under 80 cm for women, could prevent47%-58% clustering of risk factor

关键词： chinese adults Overweight Obesity BMI Waist circumference

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The associations of lens power with age,axial length and type 2 diabetes mellitus in chinese adults aged 50 and above

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Eye and Vision 2020年第1期7卷 563-570页

作者： Luyao Ye Jiangnan He Xinji Zhang Yi Xu Qiuying Chen Yao Yin Ying Fan Lina Lu Jianfeng Zhu Haidong Zou Xun Xu Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment CenterShanghai Eye HospitalNo.380 Kangding RoadShanghai 200040China Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong UniversityNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesNo.100 Haining RoadShanghai 200080China Department of Health Statistics Naval Military Medical UniversityNo.800 Xiangyin RoadShanghai 200433China

Background:To investigate the associations of lens power with age,axial length(AL),and Type 2 diabetes mellitus(DM)in chinese adults aged 50 and above.Methods:Random clustering sampling was used to identify adults aged 50 years and above in urban regions of Shanghai.The participants underwent a comprehensive ophthalmic examination including subjective refraction,autorefraction,and IOL-Master.The crystalline lens power was calculated using Bennett’s formula.Results:A total of 4177 adults were included.A linear decrease in lens power was observed both with age and with AL,followed by a stop of lens power loss after the age of 70 or when AL≥25 mm,respectively.Participants with Type 2 DM presented higher lens power(0.43 diopter(D),padults aged 50 and above exhibited two stages with age and with AL.Type 2 DM caused an increase in lens power,which was not seen in participants aged≥75 years or with AL≥25 mm.

关键词： Lens power Type 2 diabetes mellitus chinese adults Cross-sectional study

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Smoking and Its Relation to Metabolic Status among chinese adults： Analysis of a Nationwide Survey

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Biomedical and Environmental Sciences 2016年第9期29卷 619-627页

作者： DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of HealthNational Clinical Research Center for Metabolic DiseasesCollaborative Innovation Center of Systems Biomedicineand Shanghai Clinical Center for Endocrine and Metabolic DiseasesRui-Jin HospitalShanghai Jiao-Tong University School of MedicineShanghai 200025China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 102206China the 2010 china non-communicable disease surveillance group

Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall chinese adult population. Results The estimated proportion of current smokers was 28.3% for chinese adults aged _〉18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in chinese adults.

关键词： Smoking Prevalence Metabolic diseases chinese adults

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New formula for predicting standard liver volume in chinese adults

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World Journal of Gastroenterology 2017年第27期23卷 4968-4977页

作者： Ling-Mei Feng Pei-Qin Wang Hong Yu Ru-Tan Chen Jian Wang Xia Sheng Zong-Li Yuan Pei-Mei Shi Wei-Fen Xie Xin Zeng Department of Gastroenterology Shanghai Changzheng HospitalSecond Military Medical University Department of Radiology Shanghai Changzheng HospitalSecond Military Medical University

AIM To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume(SLV) in chinese adults.METHODS Computed tomography(CT)-estimated total liver volume(CTLV) was determined in 369 chinese adults. Age,sex,body weight,body height,body mass index,and body surface area(BSA) were recorded using CT. Total splenic volume,portal venous diameter(PVD),splenic venous diameter(SVD),and portal venous cross-sectional area(PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation group.RESULTS The average CTLV was 1205.41 ± 257.53 cm3(range,593.80-2250.10 cm3). The average of PVD,SVD and PVCSA was 9.34 ± 1.51 mm,7.40 ± 1.31 mm and 173.22 ± 48.11 mm2,respectively. The CT-estimated splenic volume of healthy adults varied markedly(range,46.60-2892.30 cm3). Sex,age,body height,body weight,body mass index,and BSA were significantly correlated with CTLV. BSA showed the strongest correlation(r = 0.546,P 70 years of age,and underestimated liver volume when CTLV was > 1800 cm3.CONCLUSION Our new BSA-based formula is more accurate than other formulas in estimating SLV in chinese adults.

关键词： Standard liver volume Reference range Morphological indices chinese adults

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Differences in body composition measurements assessed by air displacement plethysmography and dual-energy Xray absorptiometry in young and middle-aged chinese adults

Differences in body composition measurements assessed by air...

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中国营养学会第十五届全国营养科学大会

作者： Yiwen Huang Hongbo Dong Hong Cheng Xinying Shan Xiaoran Yu Xianghui Xie Jie Mi 国家儿童医学中心首都医科大学附属北京儿童医院儿童慢病管理中心首都儿科研究所

Dual-energy X-ray absorptiometry(DXA) and air displacement plethysmography(ADP) are two widely used methods for body composition analysis(BCA). However, little is known about the discrepancies in the results of BCA obtained from the two methods in chinese population. This study aimed to compare the measurement differences between DXA and ADP in young and middle-aged chinese adults, and to explore the influential factors of this difference. Methods A total of 186 healthy volunteers(male(51.1%) vs. female(49.9%)) who aged 18-56 years old with body mass index(BMI) of 15.9-35.9 kg/m2 were enrolled. Fat mass(FM), fat mass percentage(FMP), and fat-free mass(FFM) were analyzed by both DXA and ADP within 1 hour. Results In general, all the BCA measures of DXA and ADP were highly correlated(intraclass correlation coefficient ICC>0.80, P<0.001), while significant differences were found between the two methods. At the population level, greater body fat estimates(FM and FMP), whereas lower FFM were found for DXA than ADP. Moreover, the average difference in FM and FMP as referred to ADP changed from positive in underweight group to negative in obesity group, and vice versa for FFM. At the individual level, the proportion of relative errors for FM and FMP within ±15% was less than 10% in underweight subjects and over 75% in those with obesity. For FFM, all underweight subjects had a relative error within 15%, and the proportion was 90.5% for obese males and 85.0% for obese females. Conclusion The differences in BCA results measured by DXA and ADP were strongly influenced by BMI status at both population and individual levels. Caution should be especially taken when interchanging body fat results measured by the two methods in underweight and obese subjects.

关键词： Body composition analysis Dual-energy X-ray absorptiometry Air displacement plethysmography chinese adults Comparative study

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The Magnitude and Trends of Under and Over Nutrition in Asian Countries

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Biomedical and Environmental Sciences 2001年第1期14卷 53-60页

作者： GEKE－YOU FUDA－WEI InstituteofNutritionandFoodHygiene ChineseAcademyofPreventiveMedicine29NanweiRoadBeijing100050China InstituteofNutritionandFoodHygiene ChineseAcademyofPreventiveMedicine29Na

In order to understand the magnitude and trends of both under and over nutrition problems in Asian countries, we reviewed data available in a number of selected countries. In general, the prevalence of under nutrition is declining in this region but is still heavy in many countries. The trends varied with complexity of individual countries. In China, the prevalence of underweight, stunting and wasting was 21.6%, 30.5% and 2.6% in children of 0 4 years old (90,662 subjects, 1987). Another large scale survey in 1992(176,976 subjects) presented a prevalence of 17.1%, 33.5% and 4.5%, respectively. Recent studies showed a remarkable improvement in both underweight and stunting. The National Student Survey in 1995, however, showed that the prevalence of under nutrition was 26.9% for schoolboys and 38.3% for schoolgirls (7 18 yr). There was an increase of 4.7% and 3.5%, respectively, compared with the results of a similar survey conducted in 1985. The proportion of malnutrition in chinese adults (BMIadults (BMI>25) was increased from 9.7% to 14.9% for urban areas and from 6.15% to 8.4% for rural areas in a 10 year period (1982-1992), and the prevalence of overweight jumped from 3.38% and 2.75% in 1985 to 7.18% and 8.65% in 1995 for schoolboys and schoolgirls. In India, the incr

关键词： urban areas rural areas chinese adults young adults deal with

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Evaluation of the Factorial Method for Determination of Energy Expenditure in 16 Young Adult Women Living in China

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Biomedical and Environmental Sciences 2011年第4期24卷 357-363页

作者： LIU JianMin PIAO JianHua SUN Rui TIAN Ying YANG XiaoGuang Key Laboratory of Laboratory Animal Hebei Medical University Shijia Zhuang 050017 Hebei China Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050China

Objective The present study aimed to evaluate the accuracy of the factorial method for estimating energy needs in individuals living in China.Methods Sixteen healthy female adults aged 22.1±1.2 years with a body mass index （kg/m 2） of 20.4±1.7 were selected as subjects.In free-living conditions,energy expenditure （EE） was determined by using the factorial method.At the same time,the doubly labeled water method （DLW） was also used to measure energy expenditure of the subjects and served as the criterion method.EE predicted by the factorial method （EE factorial） was compared with the simultaneous measurement of EE by the validated DLW method （EE DLW）.Results There was excellent agreement between EE factorial （7.46±0.59 MJ/d） and EE DLW （7.64 ± 0.49 MJ/d）,with a difference of-2.6±4.9% （-0.18±0.36 MJ/d）.No significant differences were found between the two methods.EE factorial was highly correlated with EE DLW （r=0.795,P0.001） and a good agreement for individuals was found by using the Bland and Altman test.Conclusion The factorial method gives satisfactory estimates of EE for both groups and individuals living in China.

关键词： Energy expenditure chinese adults Factorial method Doubly labeled water

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Identification of Two Novel Mitochondrial DNA Deletions Induced by Ionizing Radiation

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Biomedical and Environmental Sciences 2012年第5期25卷 533-541页

作者： ZHAO Xiao Tao FENG Jiang Bin LI Yu Wen LUO Qun YANG Xin Chun LU Xue CHEN De Qing LIU Qing Jie Department of Cardiology Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Key Laboratory of Radiological Protection and Nuclear Emergency National Institute Jor Radiological Protection Chinese Center Jbr Disease Control and Prevention Beijing 100088 China Department of Transfusion chinese PLA General Hospital Beijing 100853 China

Abstract Objective We identify ionizing radiation-induced mitochondrial DNA （mtDNA） deletions in human lymphocytes and their distribution in normal populations. Methods Long-range polymerase chain reactions （PCR） using two pairs of primers specific for the human mitochondrial genome were used to analyze the lymphoblastoid cell line following exposure to 10 Gy 6~Co y-rays. Limited-condition PCR, cloning and sequencing techniques were applied to verify the mtDNA deletions detected with long-range PCR. Human peripheral blood samples were irradiated with 0, 2 and 6 Gy ^60Co y-rays, and real-time PCR analysis was performed to validate the mtDNA deletions. In order to know the distribution of mtDNA deletions in normal population, 222 healthy chinese adults were also investigated. Results Two mtDNA deletions, a 7455-bp deletion （nt475-nt7929 in heavy strand） and a 9225-bp deletion （nt7714 -nt369 in heavy strand）, occurring between two 8-bp direct repeats, were identified in lymphoblastoid cells using long-range PCR, limited-condition PCR and sequencing. These results were also observed for ^60Co y-rays irradiated human peripheral blood cells. Conclusion Two novel mtDNA deletions, a 7455-bp deletion and a 9225-bp deletion, were induced by ionizing radiation. The rate of the mtDNA deletions within a normal population was related to the donors＇ age, but was independent of gender.

关键词： Mitochondrial DNA deletion Ionizing radiation Lymphocytes chinese adults

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