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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 342-347页

作者： Qi YU En-qi LIU Si-hai ZHAO Ya-feng LI Yan-li WANG Yu-long CHEN Ke-na WEI Bing-qiao HUANG Jian-lin FAN Peng-hui YANG Research Institute of A therosclerotic Disease Xi'an Jiaotong University School of MedicineShaanxi 710061China Laboratory Animal Center Xi'an Jiaotong University School of MedicineShaanxi 710061China Department of Molecular Pathology Interdisciplinary Graduate School of Medicine and EngineeringUniversity of YamanashL Yamanashi 409-3898Japan

Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB poly- morphism of CETP was found to be associated with CAD in the chinese population.

关键词： Cholesteryl ester transfer protein Coronary artery disease Polymorphism chinese population

Risk factors and metabolic abnormality of patients with non-alcoholic fatty liver disease: Either non-obese or obese chinese population

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 45-48页

作者： Shou-Wu Lee Teng-Yu Lee Sheng-Shun Yang Chun-Fang Tung Hong-Zen Yeh Chi-Sen Chang Division of Gastroenterology Department of Internal Medicine Taichung Veterans General Hospital

Background: Non-alcoholic fatty liver disease(NAFLD) occurs not only in obese individuals but also in non-obese ones. The aim of this study was to focus on the association between NAFLD and metabolic events in a non-obese or obese chinese ***: Data collected from subjects registered at Taichung Veterans General Hospital from January to December 2009 were analyzed. The exclusion criteria were alcoholics, chronic hepatitis B or C. Patients included in analyses were assigned to four groups according to sonography of their liver(normal or NAFLD), and body mass index(BMI) levels(non-obese if BMI < 25 kg/m~2 or obese if BMI ≥ 25 kg/m~2).Results: There were 745, 208, 770 and 285 patients enrolled in four groups labeled non-obese normal liver(group A), non-obese NAFLD(group B), obese normal liver(group C) and obese NAFLD(group D),respectively. The highest ratio of metabolic syndrome existed in the group B(26.9%), followed by group A(11.7%), group D(10.9%) and finally the group C(5.2%). The positive association with NAFLD in non-obese individuals was significant in triglyceride(OR = 1.01; 95% CI: 1.01–1.02) and glucose(OR = 1.02; 95% CI:1.01–1.03), while the positive association with NAFLD in obese subjects was only significant in triglyceride(OR = 1.01; 95% CI: 1.01–1.02). The positive association was most significant in all cases(adjusted OR = 2.41; 95% CI: 1.78–3.24), especially in non-obese individuals(OR = 2.81; 95% CI: 1.92–4.12).Conclusions: Non-obese NAFLD subjects displayed a higher proportion of metabolic abnormality. Hyperlipidemia and hyperglycemia had the most positive strength association with NAFLD.

关键词： Fatty liver Non-alcoholic fatty liver disease Obese chinese population

Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the chinese population

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Science China(Life Sciences) 2016年第7期59卷 694-699页

作者： Jinghong Sang Liyun Jia Bowen Zhao Huaizhou Wang Nihong Zhang Ningli Wang Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 100730 China Beijing Ophthalmology & Visual Science Key Laboratory Capital Medical University Beijing 100730 China Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Beijing 100730 China The First Affiliated Hospital of Nanyang Medical College Nanyang 473000 China

This study investigated the genetic association of three single nucleotide polymorphisms （SNPs; rs 10483727, rs33912345, and rs146737847） at the SIX1-SIX6 locus with primar-y open angle glaucoma （POAG） in the chinese population. A total of 866 subjects with POAG （685 high-tension glaucoma （HTG） and 181 normal-tension glaucoma （NTG）） and 266 control individu- als were included. Significant genetic association was identified for rs 10483727 in HTG （P=0.02; odds ratio （OR）=l.31）, NTG （P=7.41x10-6; OR=2.71）, and POAG （i.e., HTG and NTG combined; P=0.001; OR=1.44）. rs33912345 was also significantly associated with HTG （P=0.008; OR=1.36）, NTG （P=2.72x10-6; OR=2.27）, and POAG （P=3.84x10-4; OR=1.49）. The rare SIX6 mutation, rs146737847, was not found in the subjects enrolled in this study. Stratification by patient age identified that both rs10483727 and rs33912345 were significantly associated with NTG in patients aged above 40 years （P=2.08x10-5; OR=2.28）, whereas in patients aged between 20-40 years, rs33912345 was significantly associated with NTG （P=0.017; OR=2.06）. In HTG, the genetic associations for both rs10483727 and rs33912345 were significant in patients aged between 20-40 years （P=0.006; OR= 1.56） but not in those aged above 40 years （P=0.118, 0R=1.21 and P=0.042, OR= 1.29, respec- tively）. This study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years.

关键词： primary open angle glaucoma SIX1-SIX6 chinese population

The Use of Lipoprotein-Associated Phospholipase A2 in a chinese population to Predict Cardiovascular Events

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Biomedical and Environmental Sciences 2022年第3期35卷 206-214页

作者： XI Hui CHENG Guan Liang HU Fei Fei LI Song Nan DENG Xuan ZHOU Yong Department of Cardiology Peking University International HospitalBeijing 102206China Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Centre for Cardiovascular DiseasesBeijing 100029China

Objective To explore associations between lipoprotein-associated phospholipase A2(Lp-PLA2)and the risk of cardiovascular events in a chinese population,with a long-term *** A random sample of 2,031 participants(73.6%males,mean age=60.4 years)was derived from the Asymptomatic Polyvascular Abnormalities Community study(APAC)from 2010 to *** Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay(ELISA).The composite endpoint was a combination of first-ever stroke,myocardial infarction(MI)or all-cause ***-PLA2 associations with outcomes were assessed using Cox *** The median Lp-PLA2 level was 141.0 ng/m *** a median follow-up of 9.1 years,we identified 389 events(19.2%),including 137 stroke incidents,43 MIs,and 244 all-cause *** multivariate Cox regression,when compared with the lowest Lp-PLA2 quartile,the hazard ratios with95%confidence intervals for developing composite endpoints,stroke,major adverse cardiovascular events,and all-cause death were 1.77(1.24–2.54),1.92(1.03–3.60),1.69(1.003–2.84),and 1.94(1.18–3.18)in the highest quartile,*** endpoints in 145(28.6%)patients occurred in the highest quartile where Lp-PLA2(159.0 ng/m L)was much lower than the American Association of Clinical Endocrinologists recommended cut-off point,200 ng/m *** Higher Lp-PLA2 levels were associated with an increased risk of cardiovascular event/death in a middle-aged chinese *** Lp-PLA2 cut-off point may be lower in the chinese population when predicting cardiovascular events.

关键词： Lipoprotein-associated phospholipase A2 Composite endpoint Stroke Major adverse cardiovascular events All-cause death Racial difference chinese population Asians

The Association between Exposure to Second-Hand Smoke and Disease in the chinese population: A Systematic Review and Meta-Analysis

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Biomedical and Environmental Sciences 2023年第1期36卷 24-37页

作者： WANG Yu Tong HU Kui Ru ZHAO Jian AI Fei Ling SHI Yu Lin WANG Xue Wei YANG Wen Yi WANG Jing Xin AILiMei WAN Xia Department of Epidemiology and Biostatistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

Objective To analyze the association between exposure to second-hand smoke(SHS) and 23 diseases,categorized into four classifications, among the chinese *** We searched the literature up to June 30, 2021, and eligible studies were identified according to the PECOS format: Participants and Competitors(chinese population), Exposure(SHS),Outcomes(Disease or Death), and Study design(Case-control or Cohort).Results In total, 53 studies were selected. The odds ratio(OR) for all types of cancer was 1.79(1.56–2.05), and for individual cancers was 1.92(1.42–2.59) for lung cancer, 1.57(1.40–1.76) for breast cancer, 1.52(1.12–2.05) for bladder cancer, and 1.37(1.08–1.73) for liver cancer. The OR for circulatory system diseases was 1.92(1.29–2.85), with a value of 2.29(1.26–4.159) for stroke. The OR of respiratory system diseases was 1.76(1.13–2.74), with a value of 1.82(1.07–3.11) for childhood asthma. The original ORs were also shown for other diseases. Subgroup analyses were performed for lung and breast cancer. The ORs varied according to time period and were significant during exposure in the household;For lung cancer, the OR was significant in *** The effect of SHS exposure in China was similar to that in Western countries, but its definition and characterization require further clarification. Studies on the association between SHS exposure and certain diseases with high incidence rates are insufficient.

关键词： Second-hand smoke chinese population Cancer Diseases of the respiratory system Diseases of the circulatory system Systematic review Meta-analysis

Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation chinese population

Mutations in GBA,SNCA,and VPS35 are not associated with Alzheimer's disease in a chinese population:a case-control study

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Neural Regeneration Research 2022年第3期17卷 682-689页

作者： Ya-Fei Wen Xue-Wen Xiao Lu Zhou Ya-Ling Jiang Yuan Zhu Li-Na Guo Xin Wang Hui Liu Ya-Fang Zhou Jun-Ling Wang Xin-Xin Liao Lu Shen Bin Jiao Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Geriatrics Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Central South UniversityChangshaHunan ProvinceChina Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangshaHunan ProvinceChina Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases ChangshaHunan ProvinceChina Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina

SNCA,GBA,and VPS35 are three common genes associated with Parkinson's *** studies have shown that these three genes may be associated with Alzheimer's disease(AD).However,it is unclear whether these genes increase the risk of AD in chinese *** this study,we used a targeted gene sequencing panel to screen all the exon regions and the nearby sequences of GBA,SNCA,and VPS35 in a cohort including 721 AD patients and 365 healthy controls from *** results revealed that neither common variants nor rare variants of these three genes were associated with AD in a chinese *** findings suggest that the mutations in GBA,SNCA,and VPS35 are not likely to play an important role in the genetic susceptibility to AD in chinese *** study was approved by the Ethics Committee of Xiangya Hospital,Central South University,China on March 9,2016(approval No.201603198).

关键词： Alzheimer's disease chinese population common variants GBA Parkinson's disease rare variants SNCA VPS35

Awareness of initiative practice for health in the chinese population:A questionnaire survey based on a network platform

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World Journal of Clinical Cases 2022年第16期10卷 5241-5252页

作者： Yi-Qiang Zhang Ming-Yue Zhou Meng-Yang Jiang Xiao-Yu Zhang Xin Wang Bao-Guo Wang Department of Anesthesiology Sanbo Brain HospitalCapital Medical UniversityBeijing 100095China Department of Subject Development Sanbo Brain HospitalCapital Medical UniversityBeijing 100095China Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Department of Administrative Office Sanbo Brain HospitalCapital Medical UniversityBeijing 100095China

BACKGROUND In 2016,the chinese government issued the Healthy China 2030 plan,which also produced the initiative practice for health(IPFH)***,people’s knowledge and awareness of the IPFH are *** To investigate awareness of IPFH in the chinese population and explore the relevant influential *** An internet-based self-designed questionnaire survey was used to collect respondents’demographic characteristics and awareness of health and the IPFH from March 26 to April 18,*** consciousness was assessed by the scores for different related *** Student’s t test,the Chi-square test,and multiple logistic regression analysis were performed to analyze the differences and influencing *** A total of 2678 valid questionnaires were *** the respondents,973(36.3%)had heard of the IPFH *** addition,89.5% of participants agreed with the view that the IPFH is beneficial to improving quality of life,and over half thought that a regular schedule,a reasonable diet,tobacco and alcohol control,a cheerful mood,specific life goals and plans,taking the initiative to accept health-related education and implement health knowledge,good interpersonal relationships,and regular physical examinations were closely related to the *** majority of respondents paid attention to their health and usually obtained health-related knowledge via social media and were also willing to promote the *** of the participants underestimated the role of hospitals,family doctors,and health managers in promoting the ***,monthly income,and medical-related work experience were the influencing factors for IPFH *** The chinese population has limited knowledge of the *** with strong IPFH awareness are older,earn more,and have medical-related work experience.

关键词： population health Health knowledge Attitudes Practice Awareness chinese population Initiative practice for health

A comparative genomics analysis of lung adenocarcinoma for chinese population by using panel of recurrent mutations

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The Journal of Biomedical Research 2021年第1期35卷 11-20,I0001-I0004页

作者： Wanlin Li Min Wu Qianqian Wang Kun Xu Fan Lin Qianghu Wang Renhua Guo Department of Bioinformatics Nanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Cell Biology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjingJiangsu 211166China.

Previous studies have demonstrated that chinese lung adenocarcinoma(LUAD)patients have unique genetic characteristics,however,the specific genomic features relating to the development and treatment of LUAD in the chinese population are not fully ***,we applied the ultra-deep targeted sequencing to 66 chinese LUAD samples,accompanied by comparative analysis with 162 Caucasian LUAD in The Cancer Genome *** focused on the 68 recurrently mutated genes and results revealed that the panel-based tumor mutational burden(pTMB)is significantly higher in the chinese LUAD(P=0.0017).Additionally,the percentage of smoking-associated C>A transversion is significantly lower in chinese LUAD(15.5%vs.39.7%,P=5.69×10^(-27)),while C>T transition is more frequent in chinese LUAD(35.8%vs.25.7%,P=2.67×10^(-5)),which indicated the ethnic difference in mutation ***,novel driver genes(GNAS and JAK1)that are peculiar to chinese LUAD were identified,and a more convergent distribution of mutations was observed in the chinese cohort(P=0.012)compared with scattered mutations in Caucasian *** results present a distinct genomic profile of chinese LUAD compared to Caucasians LUAD and elucidate the ethnic difference in mutation distribution besides the type and rate.

关键词： lung adenocarcinoma chinese population ethnic difference genomic characteristics targeted sequencing

Minimal improvement in coronary artery disease risk prediction in chinese population using polygenic risk scores:evidence from the China Kadoorie Biobank

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chinese Medical Journal 2023年第20期136卷 2476-2483页

作者： Songchun Yang Dong Sun Zhijia Sun Canqing Yu Yu Guo Jiahui Si Dianjianyi Sun Yuanjie Pang Pei Pei Ling Yang Iona YMillwood Robin GWalters Yiping Chen Huaidong Du Zengchang Pang Dan Schmidt Rebecca Stevens Robert Clarke Junshi Chen Zhengming Chen Jun Lv Liming Li On Behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Peking University Center for Public Health and Epidemic Preparedness&Response Beijing 100191China Fuwai Hospital chinese Academy of Medical Sciences Beijing 100730China Medical Research Council population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Qingdao Center of Disease Control and Prevention QingdaoShandong 266033China China National Center for Food Safety Risk Assessment Beijing 100738China 不详

Background:Several studies have reported that polygenic risk scores(PRSs)can enhance risk prediction of coronary artery disease(CAD)in European ***,research on this topic is far from sufficient in non-European countries,including *** aimed to evaluate the potential of PRS for predicting CAD for primary prevention in the chinese ***:Participants with genome-wide genotypic data from the China Kadoorie Biobank were divided into training(n=28,490)and testing sets(n=72,150).Ten previously developed PRSs were evaluated,and new ones were developed using clumping and thresholding or LDpred *** PRS showing the strongest association with CAD in the training set was selected to further evaluate its effects on improving the traditional CAD risk-prediction model in the testing *** risk was computed by summing the product of the weights and allele dosages across genome-wide single-nucleotide *** of the 10-year first CAD events was assessed using hazard ratios(HRs)and measures of model discrimination,calibration,and net reclassification improvement(NRI).Hard CAD(nonfatal I21-I23 and fatal I20-I25)and soft CAD(all fatal or nonfatal I20-I25)were analyzed ***:In the testing set,1214 hard and 7201 soft CAD cases were documented during a mean follow-up of 11.2 *** HR per standard deviation of the optimal PRS was 1.26(95%CI:1.19-1.33)for hard *** on a traditional CAD risk prediction model containing only non-laboratory-based information,the addition of PRS for hard CAD increased Harrell’s C index by 0.001(-0.001 to 0.003)in women and 0.003(0.001 to 0.005)in *** the different high-risk thresholds ranging from 1%to 10%,the highest categorical NRI was 3.2%(95%CI:0.4-6.0%)at a high-risk threshold of 10.0%in *** association of the PRS with soft CAD was much weaker than with hard CAD,leading to minimal or no improvement in the soft CAD ***:In this chinese population sam

关键词： Coronary artery disease Polygenic risk score Risk prediction model chinese population