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Corrected QT interval in cirrhosis:A systematic review and metaanalysis

World Journal of Hepatology 2023年第9期15卷 1060-1083页

作者： Vasileios Periklis Papadopoulos Konstantinos Mimidis Dialysis AKESIOS Dialysis CenterXanthi 67150Greece First Department of Internal Medicine Democritus University of ThraceAlexandroupolis 68100Greece

BACKGROUND Corrected QT(QTc)interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the ***,the effects of sex,age,severity,and etiology of cirrhosis on QTc have not been *** the same time,the role of treatment,acute illness,and liver transplantation(Tx)remains largely *** To determine the mean QTc in patients with cirrhosis,assess whether QTc is prolonged in patients with cirrhosis,and investigate whether QTc is affected by factors such as sex,age,severity,etiology,treatment,acute illness,and liver *** In the present systematic review and meta-analysis,the searching protocol“{[QTc]OR[QT interval]OR[QT-interval]OR[Q-T syndrome]}AND{[cirrhosis]OR[child-pugh]OR[MELD]}”was applied in PubMed,EMBASE,and Google Scholar databases to identify studies that reported QTc in patients with cirrhosis and published after ***-three studies were considered *** concerning first author,year of publication,type of study,method used,sample size,mean age,female ratio,alcoholic etiology of cirrhosis ratio,child-pugh A/B/C ratio,mean model for end-stage liver disease(MELD)score,treatment withβ-blockers,episode of acute gastrointestinal bleeding,formula for QT correction,mean pulse rate,QTc in patients with cirrhosis and controls,and QTc according to etiology of cirrhosis,sex,child-pugh stage,MELD score,and liver Tx status(pre-Tx/post-Tx)were *** Newcastle-Ottawa quality assessment scale appraised the quality of the eligible *** estimates,expressed as proportions or standardized mean differences,were combined using the randomeffects,generic inverse variance method of DerSimonian and ***,sensitivity analysis,and meta-regressions were applied to assess *** QTc combined mean in patients with cirrhosis was 444.8 ms[95%confidence interval(CI):440.4-449.2;P<0.001 when compared with the upper normal limit of 440 ms],presenting high heterog

关键词： Liver cirrhosis Corrected QT interval child-pugh stage Model for end-stage liver disease score Liver transplantation Meta-analysis

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