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Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer

World Journal of Gastroenterology 2015年第34期21卷 9966-9973页

作者： Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine

AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative ***:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of ***:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR ***:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

关键词： Colorectal cancer Prognosis Unresectable chemother

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