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Decellularized extracellular matrix biomaterials for regenerative therapies:Advances,challenges and clinical prospects

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Bioactive Materials 2024年第2期32卷 98-123页

作者： Aleksandra A.Golebiowska Jonathon T.Intravaia Vinayak M.Sathe Sangamesh G.Kumbar Syam P.Nukavarapu Department of Biomedical Engineering University of ConnecticutStorrsCT06269USA Department of Materials Science&Engineering University of ConnecticutStorrsCT06269USA Department of Orthopaedic Surgery University of Connecticut HealthFarmingtonCT06032USA

Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and ***,current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional *** address these challenges,the utilization of decellularized tissues and cell-derived extracellular matrix(ECM)has emerged as a promising *** biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment,both in vitro and in *** dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes,thereby enhancing regenerative *** this review,we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative *** discuss the need for further improvements in decellularization methods and techniques to retain structural,biological,and physicochemical characteristics of the dECM products in a way to mimic native tissues and *** article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering *** article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products.

关键词： Non-immune biomaterials and grafts Native micro-environment Bio-chemical cues chemotactic ability Tissue-inks Clinical therapies

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Chemoattractive capacity of different lengths of nerve fragments bridging regeneration chambers for the repair of sciatic nerve defects

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Neural Regeneration Research 2012年第29期7卷 2293-2298页

作者： Jiren Zhang Yubo Wang Jincheng Zhang Department of Hand Surgery First Affiliated Hospital of Liaoning Medical UniversityJinzhou 121001Liaoning ProvinceChina

A preliminary study by our research group showed that 6-mm-long regeneration chamber bridging is equivalent to autologous nerve transplantation for the repair of 12-mm nerve defects. In this study, we compared the efficacy of different lengths （6, 8, 10 mm） of nerve fragments bridging 6-mm regeneration chambers for the repair of 12-mm-long nerve defects. At 16 weeks after the regeneration chamber was implanted, the number, diameter and myelin sheath thickness of the regenerated nerve fibers, as well as the conduction velocity of the sciatic nerve and gastrocnemius muscle wet weight ratio, were similar to that observed with autologous nerve transplantation. Our results demonstrate that 6-, 8-and 10-mm-long nerve fragments bridging 6-mm regeneration chambers effectively repair 12-mm-long nerve defects. Because the chemoattractive capacity is not affected by the length of the nerve fragment, we suggest adopting 6-mm-long nerve fragments for the repair of peripheral nerve defects.

关键词： nerve fragment length nerve regeneration chamber bridging long nerve defect chemotactic ability neural regeneration

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